公开(公告)号：US09801867B2

公开(公告)日：2017-10-31

申请号：US15175824

申请日：2016-06-07

Applicant: AMGEN INC.

Inventor： Matthew Bio ,  Sebastien Caille ,  Brian Cochran ,  Yuanqing Fang ,  Brian M. Fox ,  Brian S. Lucas ,  Lawrence R. McGee ,  Filisaty Vounatsos ,  Sean H. Wiedemann ,  Sarah Wortman

IPC: C07D211/76 ,  A61K31/451 ,  C07D211/94 ,  C07D491/048 ,  C07C309/25 ,  C07C309/04 ,  C07C313/02 ,  C07D498/04 ,  C07C309/35

CPC classification number: A61K31/451 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/25 ,  C07C309/35 ,  C07C313/02 ,  C07D211/76 ,  C07D211/94 ,  C07D491/048 ,  C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

公开(公告)号：US09623018B2

公开(公告)日：2017-04-18

申请号：US15175805

申请日：2016-06-07

Applicant: AMGEN INC.

Inventor： Matthew Bio ,  Sebastien Caille ,  Yuanqing Fang ,  Brian M. Fox ,  Brian S. Lucas ,  Lawrence R. McGee ,  Sean H. Wiedemann

IPC: C07D498/04 ,  A61K31/451 ,  C07D211/94 ,  C07D491/048 ,  C07C309/25 ,  C07C309/04 ,  C07D211/76 ,  C07C309/35

CPC classification number: A61K31/451 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/25 ,  C07C309/35 ,  C07C313/02 ,  C07D211/76 ,  C07D211/94 ,  C07D491/048 ,  C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

公开(公告)号：US20160068545A1

公开(公告)日：2016-03-10

申请号：US14839149

申请日：2015-08-28

Applicant: AMGEN INC.

Inventor： Sean P. BROWN ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Brian S. Lucas ,  Nick A. Paras ,  Joshua Taygerly ,  Marc VIMOLRATANA ,  Xianghong Wang ,  Ming Yu ,  Manuel ZANCANELLA ,  Liusheng Zhu ,  Ana GONZALEZ BUENROSTRO ,  Zhihong LI

IPC: C07D513/10

CPC classification number: C07D513/10 ,  C07D513/08

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract translation: 本文提供了骨髓细胞白血病1蛋白（Mcl-1）抑制剂，其制备方法，相关药物组合物及其使用方法。 例如，本文提供了式I化合物及其药学上可接受的盐和含有这些化合物的药物组合物。 本文提供的化合物和组合物可用于例如治疗疾病或病症如癌症。