公开(公告)号：US10100063B2

公开(公告)日：2018-10-16

申请号：US15376456

申请日：2016-12-12

Applicant: AMGEN INC.

Inventor： Sean P. Brown ,  Yunxiao Li ,  Mike Elias Lizarzaburu ,  Brian S. Lucas ,  Nick A. Paras ,  Joshua Taygerly ,  Marc Vimolratana ,  Xianghong Wang ,  Ming Yu ,  Manuel Zancanella ,  Liusheng Zhu ,  Ana Gonzalez Buenrostro ,  Zhihong Li

IPC: C07D513/10 ,  C07D513/08

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20160068545A1

公开(公告)日：2016-03-10

申请号：US14839149

申请日：2015-08-28

Applicant: AMGEN INC.

Inventor： Sean P. BROWN ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Brian S. Lucas ,  Nick A. Paras ,  Joshua Taygerly ,  Marc VIMOLRATANA ,  Xianghong Wang ,  Ming Yu ,  Manuel ZANCANELLA ,  Liusheng Zhu ,  Ana GONZALEZ BUENROSTRO ,  Zhihong LI

IPC: C07D513/10

CPC classification number: C07D513/10 ,  C07D513/08

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract translation: 本文提供了骨髓细胞白血病1蛋白（Mcl-1）抑制剂，其制备方法，相关药物组合物及其使用方法。 例如，本文提供了式I化合物及其药学上可接受的盐和含有这些化合物的药物组合物。 本文提供的化合物和组合物可用于例如治疗疾病或病症如癌症。

公开(公告)号：US20140163052A1

公开(公告)日：2014-06-12

申请号：US14088796

申请日：2013-11-25

Applicant: AMGEN INC.

Inventor： Xiaoqi Chen ,  Kang Dai ,  Jason Duquette ,  Michael W. Gribble, JR. ,  Justin N. Huard ,  Kathleen S. Keegan ,  Zhihong Li ,  Sarah E. Lively ,  Lawrence R. McGee ,  Mark L. Ragains ,  Xianghong Wang ,  Margaret F. Weidner ,  Jian Zhang

IPC: C07D471/14

CPC classification number: C07D519/00 ,  C07D471/14

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

Abstract translation: 式I化合物是CDK 4，CDK 6和FLT 3的有用抑制剂。 这些化合物可用于治疗癌症和各种其他疾病状况。 式I的化合物具有以下结构：其中R1是式IA，式IB，式IC或式ID的基团，并且本文提供了其它变量的定义。

公开(公告)号：US09562061B2

公开(公告)日：2017-02-07

申请号：US14839149

申请日：2015-08-28

Applicant: AMGEN INC.

Inventor： Sean P. Brown ,  Yunxiao Li ,  Joshua Taygerly ,  Marc Vimolratana ,  Xianghong Wang ,  Manuel Zancanella

IPC: C07D513/10 ,  C07D513/08

CPC classification number: C07D513/10 ,  C07D513/08

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract translation: 本文提供了骨髓细胞白血病1蛋白（Mcl-1）抑制剂，其制备方法，相关药物组合物及其使用方法。 例如，本文提供了式I化合物及其药学上可接受的盐和含有这些化合物的药物组合物。 本文提供的化合物和组合物可用于例如治疗疾病或病症如癌症。

公开(公告)号：US11306107B2

公开(公告)日：2022-04-19

申请号：US16078152

申请日：2017-02-24

Applicant: AMGEN INC.

Inventor： Sean P. Brown ,  David Karl Bedke ,  Michael R. Degraffenreid ,  Jiasheng Fu ,  Zhihong Li ,  Felix Gonzalez Lopez De Turiso ,  Ana Gonzalez Buenrostro ,  Michael W. Gribble, Jr. ,  Michael G. Johnson ,  Todd J. Kohn ,  Kexue Li ,  Yunxiao Li ,  Mike Elias Lizarzaburu ,  Yosup Rew ,  Joshua Taygerly ,  Yingcai Wang ,  Xuelei Yan ,  Ming Yu ,  Jiang Zhu ,  Manuel Zancanella ,  Xian Yun Jiao ,  Liusheng Zhu ,  Xianghong Wang ,  Julio C. Medina ,  Jason A. Duquette ,  Jonathan B. Houze ,  Marc Vimolratana ,  Mario G. Cardozo ,  Alan C. Cheng

IPC: C07D513/10 ,  C07D513/20 ,  C07D515/10

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US09359355B2

公开(公告)日：2016-06-07

申请号：US14088796

申请日：2013-11-25

Applicant: AMGEN INC.

Inventor： Xiaoqi Chen ,  Kang Dai ,  Jason Duquette ,  Michael W. Gribble, Jr. ,  Justin N. Huard ,  Kathleen S. Keegan ,  Zhihong Li ,  Sarah E. Lively ,  Lawrence R. McGee ,  Mark L. Ragains ,  Xianghong Wang ,  Margaret F. Weidner ,  Jian Zhang

IPC: C07D471/14 ,  C07D519/00

CPC classification number: C07D519/00 ,  C07D471/14

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

Abstract translation: 式I化合物是CDK 4，CDK 6和FLT 3的有用抑制剂。 这些化合物可用于治疗癌症和各种其他疾病状况。 式I的化合物具有以下结构：其中R1是式IA，式IB，式IC或式ID的基团，并且本文提供了其它变量的定义。