公开(公告)号：US20160068545A1

公开(公告)日：2016-03-10

申请号：US14839149

申请日：2015-08-28

申请人： AMGEN INC.

发明人： Sean P. BROWN ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Brian S. Lucas ,  Nick A. Paras ,  Joshua Taygerly ,  Marc VIMOLRATANA ,  Xianghong Wang ,  Ming Yu ,  Manuel ZANCANELLA ,  Liusheng Zhu ,  Ana GONZALEZ BUENROSTRO ,  Zhihong LI

IPC分类号： C07D513/10

CPC分类号： C07D513/10 ,  C07D513/08

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

摘要翻译： 本文提供了骨髓细胞白血病1蛋白（Mcl-1）抑制剂，其制备方法，相关药物组合物及其使用方法。 例如，本文提供了式I化合物及其药学上可接受的盐和含有这些化合物的药物组合物。 本文提供的化合物和组合物可用于例如治疗疾病或病症如癌症。

公开(公告)号：US20190023720A1

公开(公告)日：2019-01-24

申请号：US16121750

申请日：2018-09-05

申请人： AMGEN INC.

发明人： Sean P. BROWN ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Brian S, LUCAS ,  Nick A. PARAS ,  Joshua TAYGERLY ,  Marc VIMOLRATANA ,  Xianghong WANG ,  Ming YU ,  Manuel ZANCANELLA ,  Liusheng ZHU ,  Ana GONZALEZ BUENROSTRO ,  Zhihong LI

IPC分类号： C07D513/10 ,  C07D513/08

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20160039774A1

公开(公告)日：2016-02-11

申请号：US14774645

申请日：2014-03-13

申请人： AMGEN INC.

发明人： Ana GONZALEZ BUENROSTRO ,  Yihong LI ,  Julio C. MEDINA ,  Steven H. OLSON

IPC分类号： C07D265/32

CPC分类号： C07D265/32 ,  C07D413/06 ,  C07D417/06

摘要： The present invention provides MDM2 inhibitor compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor of Formula (I).

摘要翻译： 本发明提供式（I）的MDM2抑制剂化合物或其药学上可接受的盐，其中变量如上所定义，哪些化合物可用作治疗剂，特别是用于治疗癌症。 本发明还涉及含有式（I）的MDM2抑制剂的药物组合物。

公开(公告)号：US20210047344A1

公开(公告)日：2021-02-18

申请号：US16977527

申请日：2019-03-04

申请人： AMGEN INC.

发明人： Gwenaella RESCOURIO ,  Ana GONZALEZ BUENROSTRO ,  Sean P. BROWN ,  Mike LIZARZABURU ,  Julio MEDINA ,  Salman Yojiro JABRI ,  Daqing SUN ,  Scott Preston SIMONOVICH ,  Xuelei YAN ,  Yihong LI ,  Yosup REW

IPC分类号： C07D498/10 ,  C07D498/20 ,  C07D519/00

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20190016736A1

公开(公告)日：2019-01-17

申请号：US16123030

申请日：2018-09-06

申请人： AMGEN INC.

发明人： Sean P. BROWN ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Brian S. LUCAS ,  Nick A. PARAS ,  Joshua TAYGERLY ,  Marc VIMOLRATANA ,  Xianghong WANG ,  Ming YU ,  Manuel ZANCANELLA ,  Liusheng ZHU ,  Ana GONZALEZ BUENROSTRO ,  Zhihong LI

IPC分类号： C07D513/10 ,  C07D513/08

摘要： Provided herein are compounds that are useful intermediates that may used to synthesize myeloid cell leukemia 1 protein (Mcl-1) inhibitors. Also provided are Mcl-1 inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20230052348A1

公开(公告)日：2023-02-16

申请号：US17501075

申请日：2021-10-14

申请人： AMGEN INC.

发明人： Sean P BROWN ,  David Karl BEDKE ,  Michael R. DEGRAFFENREID ,  Jiasheng FU ,  Zhinghong LI ,  Felix GONZALEZ LOPEZ DE TURISO ,  Ana GONZALEZ BUENROSTRO ,  Michael W. GRIBBLE JR. ,  Michael G. JOHNSON ,  Todd J. KOHN ,  Kexue LI ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Yosup REW ,  Joshua TAYGERLY ,  Yingcai WANG ,  Xuelei YAN ,  Ming YU ,  Jiang ZHU ,  Manuel ZANCANELLA ,  Xian Yun JIAO ,  Liusheng ZHU ,  Xianghong WANG ,  Julio C. MEDINA ,  Jason A. DUQUETTE ,  Jonathan B. HOUZE ,  Marc VIMOLRATANA ,  Mario G. CARDOZO ,  Alan C. CHENG

IPC分类号： C07D513/10 ,  C07D513/20 ,  C07D515/10

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20200062780A1

公开(公告)日：2020-02-27

申请号：US16569927

申请日：2019-09-13

申请人： AMGEN INC.

发明人： Sean P. BROWN ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Brian S. LUCAS ,  Nick A. PARAS ,  Joshua TAYGERLY ,  Marc VIMOLRATANA ,  Xianghong WANG ,  Ming YU ,  Manuel ZANCANELLA ,  Liusheng ZHU ,  Ana GONZALEZ BUENROSTRO ,  Zhihong LI

IPC分类号： C07D513/10 ,  C07D498/00 ,  C07D513/08

摘要： Provided herein are compounds that are useful intermediates that may used to synthesize myeloid cell leukemia 1 protein (Mcl-1) inhibitors. Also provided are Mcl-1 inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20170088560A1

公开(公告)日：2017-03-30

申请号：US15376456

申请日：2016-12-12

申请人： AMGEN INC.

发明人： Sean P. BROWN ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Brian S. LUCAS ,  Nick A. PARAS ,  Joshua TAYGERLY ,  Marc VIMOLRATANA ,  Xianghong WANG ,  Ming YU ,  Manuel ZANCANELLA ,  Liusheng ZHU ,  Ana GONZALEZ BUENROSTRO ,  Zhihong LI

IPC分类号： C07D513/10

CPC分类号： C07D513/10 ,  C07D513/08

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20210230189A1

公开(公告)日：2021-07-29

申请号：US16078152

申请日：2017-02-24

申请人： AMGEN INC.

发明人： Sean P. BROWN ,  David Karl BEDKE ,  Micheal R. DEGRAFFENREID ,  Jiasheng FU ,  Zhihong LI ,  Felix GONZALEZ LOPEZ TURISO ,  Ana GONZALEZ BUENROSTRO ,  Micheal W. GRIBBLE, JR. ,  Micheal G. JOHNSON ,  Todd J. KOHN ,  Kexue LI ,  Yunxiao LI ,  Mike Elias LIZARZABURU ,  Yosup REW ,  Joshua TAYGERLY ,  Yingcal WANG ,  Xuelei YAN ,  Ming YU ,  Jiang ZHU ,  Manuel ZANCANELLA ,  Xian Yun JIAO ,  Liusheng ZHU ,  Xianghong WANG ,  Julio C. MEDINA ,  Jason A. DUQUETTE ,  Jonathan B. HOUZE ,  Marc VIMOLRATANA ,  Marlo G. CARDOZO ,  Alan C. CHENG

IPC分类号： C07D513/10 ,  C07D515/10 ,  C07D513/20

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US20170144971A1

公开(公告)日：2017-05-25

申请号：US15412804

申请日：2017-01-23

申请人： AMGEN INC.

发明人： Michael D. BARTBERGER ,  Ana GONZALEZ BUENROSTRO ,  Hilary Plake BECK ,  Xiaoqi CHEN ,  Richard Victor CONNORS ,  Jeffrey DEIGNAN ,  Jason A. DUQUETTE ,  John EKSTEROWICZ ,  Benjamin FISHER ,  Brian M. FOX ,  Jiasheng FU ,  Zice FU ,  Felix GONZALEZ LOPEZ DE TURISO ,  Michael W. GRIBBLE, Jr. ,  Darin J. GUSTIN ,  Julie A. HEATH ,  Xin HUANG ,  XianYun JIAO ,  Michael G. JOHNSON ,  Frank KAYSER ,  David John KOPECKY ,  SuJen LAI ,  Yihong LI ,  Zhihong LI ,  Jiwen LIU ,  Jonathan D. LOW ,  Brian S. LUCAS ,  Zhihua MA ,  Lawrence R. MCGEE ,  Joel MCINTOSH ,  Dustin L. MCMINN ,  Julio C. MEDINA ,  Jeffrey Thomas MIHALIC ,  Steven H. OLSON ,  Yosup REW ,  Phillip M. ROVETO ,  Daqing SUN ,  Xiaodong WANG ,  Yingcai WANG ,  Xuelei YAN ,  Ming YU ,  Jiang ZHU

IPC分类号： C07D211/76 ,  C07D417/12 ,  C07D413/06 ,  C07D471/10 ,  C07D409/04 ,  C07D417/06 ,  C07D405/04 ,  C07D401/04 ,  C07D279/02 ,  C07D401/12 ,  C07D491/08 ,  C07D498/08 ,  C07D409/12 ,  C07D405/12 ,  C07D417/14 ,  C07D498/20 ,  C07D401/06

CPC分类号： C07D211/76 ,  C07D221/20 ,  C07D279/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D407/04 ,  C07D407/06 ,  C07D409/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/08 ,  C07D491/153 ,  C07D498/08 ,  C07D498/14 ,  C07D498/20

摘要： The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.