公开(公告)号：US20240140966A1

公开(公告)日：2024-05-02

申请号：US18296211

申请日：2023-04-05

Applicant: AMGEN INC.

Inventor： Yosup Rew ,  Van Luu ,  Manuel Zancanella ,  Mary Chaves

IPC: C07D513/10

CPC classification number: C07D513/10

Abstract: Disclosed herein are crystalline and amorphous forms of (1S,3′R,6′R,7′S,8′E,11′S,12′R)-6-chloro-7′-methoxy-11′,12′-dimethyl-3,4-dihydro-2H, 15′H-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,6,019,24]pentacosa[8,16,18,24]tetraen]-15′-one 13′,13′-dioxide (AMG 176):




and salts and hydrates thereof. Also disclosed are methods of making the crystalline and amorphous forms, and methods of treating diseases and disorders with the crystalline and amorphous forms.

公开(公告)号：US11306107B2

公开(公告)日：2022-04-19

申请号：US16078152

申请日：2017-02-24

Applicant: AMGEN INC.

Inventor： Sean P. Brown ,  David Karl Bedke ,  Michael R. Degraffenreid ,  Jiasheng Fu ,  Zhihong Li ,  Felix Gonzalez Lopez De Turiso ,  Ana Gonzalez Buenrostro ,  Michael W. Gribble, Jr. ,  Michael G. Johnson ,  Todd J. Kohn ,  Kexue Li ,  Yunxiao Li ,  Mike Elias Lizarzaburu ,  Yosup Rew ,  Joshua Taygerly ,  Yingcai Wang ,  Xuelei Yan ,  Ming Yu ,  Jiang Zhu ,  Manuel Zancanella ,  Xian Yun Jiao ,  Liusheng Zhu ,  Xianghong Wang ,  Julio C. Medina ,  Jason A. Duquette ,  Jonathan B. Houze ,  Marc Vimolratana ,  Mario G. Cardozo ,  Alan C. Cheng

IPC: C07D513/10 ,  C07D513/20 ,  C07D515/10

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US10100063B2

公开(公告)日：2018-10-16

申请号：US15376456

申请日：2016-12-12

Applicant: AMGEN INC.

Inventor： Sean P. Brown ,  Yunxiao Li ,  Mike Elias Lizarzaburu ,  Brian S. Lucas ,  Nick A. Paras ,  Joshua Taygerly ,  Marc Vimolratana ,  Xianghong Wang ,  Ming Yu ,  Manuel Zancanella ,  Liusheng Zhu ,  Ana Gonzalez Buenrostro ,  Zhihong Li

IPC: C07D513/10 ,  C07D513/08

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

公开(公告)号：US09562061B2

公开(公告)日：2017-02-07

申请号：US14839149

申请日：2015-08-28

Applicant: AMGEN INC.

Inventor： Sean P. Brown ,  Yunxiao Li ,  Joshua Taygerly ,  Marc Vimolratana ,  Xianghong Wang ,  Manuel Zancanella

IPC: C07D513/10 ,  C07D513/08

CPC classification number: C07D513/10 ,  C07D513/08

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract translation: 本文提供了骨髓细胞白血病1蛋白（Mcl-1）抑制剂，其制备方法，相关药物组合物及其使用方法。 例如，本文提供了式I化合物及其药学上可接受的盐和含有这些化合物的药物组合物。 本文提供的化合物和组合物可用于例如治疗疾病或病症如癌症。