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    IMPEDANCE BASED DEVICES AND METHODS FOR USE IN ASSAYS
    11.
    发明申请
    IMPEDANCE BASED DEVICES AND METHODS FOR USE IN ASSAYS 有权
    基于阻抗的设备和用于测量的方法

    公开(公告)号：US20140057283A1

    公开(公告)日：2014-02-27

    申请号：US13802174

    申请日：2013-03-13

    Applicant: ACEA BIOSCIENCES, INC

    Inventor： Xiaobo Wang ,  Xiao Xu

    IPC: G01N27/02

    CPC classification number: G01N27/02 ,  C12M23/12 ,  C12M41/36 ,  G01N27/3276 ,  Y10T29/49117

    Abstract: A method for assaying target molecules in a sample liquid, the method comprising: providing an impedance monitoring device operably connected to an impedance analyzer; adding a sample liquid suspected of having target molecules to the well thereby permitting binding of target molecules to the capture molecules; monitoring impedance of the well; and determining the presence, amount or concentration of target molecules in the liquid sample from the monitored impedance. The device includes a nonconducting substrate having a well, at least two electrodes fabricated on a bottom of the well and on a same plane, wherein the surfaces of the at least two electrodes are modified with capture molecules configured to bind target molecules in a liquid sample, and at least two connection pads electrically connected to the at least two electrodes.

    Abstract translation: 一种用于测定样品液体中的靶分子的方法，所述方法包括：提供可操作地连接到阻抗分析仪的阻抗监测装置; 将怀疑具有靶分子的样品液体加入到孔中，从而允许靶分子与捕获分子的结合; 监测井的阻抗; 以及从所监测的阻抗确定液体样品中靶分子的存在，量或浓度。 该器件包括具有阱的非导电衬底，至少两个电极，其制造在阱的底部并且在同一平面上，其中至少两个电极的表面被配置成结合在液体样品中的靶分子结合的俘获分子 以及至少两个电连接到所述至少两个电极的连接焊盘。

    EGFR modulators and uses thereof
    18.
    发明授权
    EGFR modulators and uses thereof 有权
    EGFR调节剂及其用途

    公开(公告)号：US08685988B2

    公开(公告)日：2014-04-01

    申请号：US13917514

    申请日：2013-06-13

    Applicant: ACEA Biosciences Inc.

    Inventor： Xiao Xu ,  Xiaobo Wang ,  Long Mao ,  Li Zhao ,  Biao Xi

    IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC classification number: A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  A61K2300/00

    Abstract: The present invention relates to certain pyrrolopyrimidine derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for the treatment of tumors and related diseases related to the dysregulation of kinase (such as EGFR (including HER), Alk, PDGFR, but not limited to) pathways.

    Abstract translation: 本发明涉及某些吡咯并嘧啶衍生物，含有它们的药物组合物及其使用方法，包括治疗肿瘤的方法和与激酶失调相关的相关疾病（如EGFR（包括HER），Alk，PDGFR），但是 途径。

    LABEL-FREE MONITORING OF EXCITATION-CONTRACTION COUPLING AND EXCITABLE CELLS USING IMPEDANCE BASED SYSTEMS WITH MILLISECOND TIME RESOLUTION
    20.
    发明申请
    LABEL-FREE MONITORING OF EXCITATION-CONTRACTION COUPLING AND EXCITABLE CELLS USING IMPEDANCE BASED SYSTEMS WITH MILLISECOND TIME RESOLUTION 审中-公开

    公开(公告)号：US20180306771A1

    公开(公告)日：2018-10-25

    申请号：US16020679

    申请日：2018-06-27

    Applicant: ACEA Biosciences, Inc.

    Inventor： Xiaobo Wang ,  Yama A. Abassi ,  Biao Xi ,  Wen Fu Zhang ,  Xiao Xu

    IPC: G01N33/483

    Abstract: A system for monitoring cell-substrate impedance of excitable cells and monitoring the beating cycle of cardiomyocytes, the system including: a device for monitoring cell-substrate impedance at 20 millisecond time resolution, the device having one or more wells on a nonconductive substrate, wherein at least one well of the one or more wells comprises an electrode array fabricated on the substrate for measurement of cell-substrate impedance at 20 millisecond time resolution; an impedance analyzer that measures cell-substrate impedance from the at least one well at 20 millisecond time resolution; electronic circuitry that electrically connects the electrode array from the at least one well to the impedance analyzer; and a software program that analyzes the measured cell-substrate impedance.

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