摘要:
An integrated fuel rail portion and mounting bracket assembly is provided. The assembly includes an elongated support portion and at least one mounting bracket integrally connected to the elongated support portion. A method of forming the assembly is also provided.
摘要:
The present disclosure relates to methods for expressing human insulin derivative in which the motif Leucine-Proline-X-Threonine appears at end of B-chain, where X is any amino acid residue. Said human insulin derivative is expressed using insulin derivative peptide and sortase. The method is to translate a nucleotide sequence encoding a single chain peptide into a precursor of human insulin derivative and combine the single chain peptide with sortase to convert a human insulin derivative precursor into a fully folded, biologically active human insulin derivative.
摘要:
The present invention relates to insulin derivatives which, in comparison to insulin glulisine and similar derivatives, has a simplified process for synthesis. In particular, the present invention relates to insulin derivatives or physiologically tolerable salts thereof in which the motif Leucine-Proline-X-Threonine appears at the end of the B-chain, where X is any amino acid residue. Due to the nature of the process, the A-chain and B-chain must begin with a Glycine amino acid residue.
摘要:
An intake manifold (10) includes a fuel rail cavity (30) which receives a metallic fuel rail (14) enclosed by a molded fuel rail cavity cover (32). The fuel rail (14) communicates with each of a plurality of engine cylinders (16) through a fuel module (18). An injector cup (28) fits upon each module cylinder to provide an interface between the fuel module and the fuel rail. Another intake manifold (10) includes a fuel rail (14) which directly interfaces with each fuel module (18) through a bellows (38) attached directly thereto.
摘要:
A noise-maker includes an enclosed membrane having an inlet and an outlet that is filled with porous material. The noise-maker is in an inflated state when the porous material is saturated with air and a compressed state when the air is forced out of the porous material. When pressure is applied to the noise-maker, the air inside the membrane is forced through the outlet and the noise-maker reaches the compressed state. When the pressure is released, the noise-maker changes from the compressed state to the inflated state as air flows through the inlet.
摘要:
A fuel rail for a fuel injection system is disclosed. The fuel rail includes a first portion including a generally elongated base, at least one mounting bracket and a plurality of fuel cup openings in the generally elongated base. The fuel rail also comprises a second, generally U-shaped, portion having a first and second opposing sides. Each of the first and second opposing sides are sealingly connected to the generally elongated base with a laser weld. The second portion also has a supply end having a fuel supply opening, and a closed end, distal from the supply end. The closed end and the supply end are sealingly connected to the generally elongated base with a laser weld. A method of manufacturing the fuel rail is also disclosed.
摘要:
The present invention relates to insulin derivatives which, in comparison to insulin glulisine and similar derivatives, has a simplified process for synthesis. In particular, the present invention relates to insulin derivatives or physiologically tolerable salts thereof in which the motif Leucine-Proline-X-Threonine appears at the end of the B-chain, where X is any amino acid residue. Due to the nature of the process, the A-chain and B-chain must begin with a Glycine amino acid residue.
摘要:
Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered.
摘要:
A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.