公开(公告)号：US07264184B2

公开(公告)日：2007-09-04

申请号：US10965691

申请日：2004-10-14

申请人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Vitaliy V. Nesterenko ,  Igor V. Kolomitsyn ,  Chris F. Edwardson

发明人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Vitaliy V. Nesterenko ,  Igor V. Kolomitsyn ,  Chris F. Edwardson

IPC分类号： B02C19/00

CPC分类号： C07D303/38 ,  C07C29/86 ,  C07C51/367 ,  C07C51/43 ,  C07C59/01 ,  C07C59/105 ,  C07J63/008 ,  D21B1/023 ,  C07C31/10 ,  C07C31/08 ,  C07C31/04

摘要： The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.

摘要翻译： 本发明提供了将桦树皮与内桦树皮分离的方法。 本发明还提供了分离白蛋白的方法; lupeol 桦木酸 9,10-环氧-18-羟基十八烷酸; 9,10,18-三羟基十八烷酸; 来自桦树皮的多酚聚合物和脂肪酸。

公开(公告)号：US07034194B2

公开(公告)日：2006-04-25

申请号：US10012337

申请日：2001-12-12

申请人： Jeremy E. Dahl ,  Robert M. Carlson

发明人： Jeremy E. Dahl ,  Robert M. Carlson

IPC分类号： C07C13/28 ,  C07C7/00 ,  C07C7/14

CPC分类号： B82Y30/00 ,  B82Y10/00 ,  C07C7/04 ,  C07C7/12 ,  C07C7/135 ,  C07C13/64 ,  C07C2603/90 ,  C08G61/02 ,  C08L65/00

摘要： Disclosed are compositions comprising one or more decamantanes. Specifically disclosed are compositions comprising 25 to 100 weight percent of one or more decamantanes. Also disclosed are novel processes for the separation and isolation of decamantane components into recoverable fractions from a feedstock containing at least a higher diamondoid component which contains one or more decamantane components.

公开(公告)号：US06815553B2

公开(公告)日：2004-11-09

申请号：US10068272

申请日：2002-02-06

申请人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Vitaliy V. Nesterenko ,  Igor V. Kolomitsyn ,  Chris F. Edwardson

发明人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Vitaliy V. Nesterenko ,  Igor V. Kolomitsyn ,  Chris F. Edwardson

IPC分类号： C07C100

CPC分类号： C07D303/38 ,  C07C29/86 ,  C07C51/367 ,  C07C51/43 ,  C07C59/01 ,  C07C59/105 ,  C07J63/008 ,  D21B1/023 ,  C07C31/10 ,  C07C31/08 ,  C07C31/04

摘要： The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.

摘要翻译： 本发明提供了将桦树皮与内桦树皮分离的方法。 本发明还提供了分离白蛋白的方法; lupeol 桦木酸 9,10-环氧-18-羟基十八烷酸; 9,10,18-三羟基十八烷酸; 来自桦树皮的多酚聚合物和脂肪酸。

公开(公告)号：US06783589B2

公开(公告)日：2004-08-31

申请号：US10047044

申请日：2002-01-14

申请人： Jeremy E. Dahl ,  Robert M. Carlson ,  Shenggao Liu

发明人： Jeremy E. Dahl ,  Robert M. Carlson ,  Shenggao Liu

IPC分类号： C30B2904

CPC分类号： H01J1/3048 ,  B82Y10/00 ,  B82Y30/00 ,  C07C4/00 ,  C07C7/04 ,  C07C7/12 ,  C07C7/135 ,  C07C13/64 ,  C07C17/10 ,  C07C17/16 ,  C07C17/383 ,  C07C17/395 ,  C07C23/20 ,  C07C39/17 ,  C07C47/347 ,  C07C49/423 ,  C07C205/05 ,  C07C211/50 ,  C07C2603/54 ,  C07C2603/90 ,  C08G61/00 ,  C08G61/02 ,  C08G83/00 ,  C08L65/00 ,  H01J2201/30457 ,  H01L23/3732 ,  H01L24/45 ,  H01L24/48 ,  H01L2224/451 ,  H01L2224/45124 ,  H01L2224/45144 ,  H01L2224/48247 ,  H01L2924/00014 ,  H01L2924/01012 ,  H01L2924/01019 ,  H01L2924/0102 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/19041 ,  H01L2924/00 ,  H01L2224/05599 ,  H01L2924/00012

摘要： Novel uses of diamondoid-containing materials in the field of microelectronics are disclosed. Embodiments include, but are not limited to, thermally conductive films in integrated circuit packaging, low-k dielectric layers in integrated circuit multilevel interconnects, thermally conductive adhesive films, thermally conductive films in thermoelectric cooling devices, passivation films for integrated circuit devices (ICs), and field emission cathodes. The diamondoids employed in the present invention may be selected from lower diamondoids, as well as the newly provided higher diamondoids, including substituted and unsubstituted diamondoids. The higher diamondoids include tetramantane, pentamantane, hexamantane, heptamantane, octamantane, nonamantane, decamantane, and undecamantane. The diamondoid-containing material may be fabricated as a diamondoid-containing polymer, a diamondoid-containing sintered ceramic, a diamondoid ceramic composite, a CVD diamondoid film, a self-assembled diamondoid film, and a diamondoid-fullerene composite.

摘要翻译： 公开了在微电子学领域中含有金刚石的材料的新用途。 实施例包括但不限于集成电路封装中的导热膜，集成电路多层互连中的低k电介质层，导热粘合剂膜，热电冷却器件中的导热膜，用于集成电路器件（IC）的钝化膜 和场致发射阴极。 本发明中使用的类金刚石可以选自下面的金刚石，以及新提供的更高的金刚石，包括取代和未取代的金刚石。 较高的类金刚石包括四聚烷，五金刚，六金刚，七金刚烷，八甲烷，非金刚烷，十烷金和十一烷。 含金刚石的材料可以制造为含有金刚石的聚合物，含金刚石的烧结陶瓷，金刚石陶瓷复合材料，CVD金刚石膜，自组装的金刚石膜和类金刚石 - 富勒烯复合材料。

公开(公告)号：US06642217B2

公开(公告)日：2003-11-04

申请号：US09969553

申请日：2001-10-01

申请人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Raj Karim

发明人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Raj Karim

IPC分类号： A61K3156

CPC分类号： C07J63/008 ,  A61K31/56

摘要： Methods of treating a fungal or yeast infection and of killing or inhibiting fungi or yeast are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.

公开(公告)号：US06407270B1

公开(公告)日：2002-06-18

申请号：US09896803

申请日：2001-06-29

申请人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Vitaliy V. Nesterenko

发明人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Vitaliy V. Nesterenko

IPC分类号： C11C3100

CPC分类号： C07C51/367 ,  C07C51/16 ,  C07C62/32 ,  C07C67/08 ,  C07C67/14 ,  C07C67/29 ,  C07C2603/52 ,  C07C69/013 ,  C07C69/16 ,  C07C69/78 ,  C07C69/14

摘要： The present invention provides a method for preparing an ester of betulin at the 3-position, e.g., betulin-3-acetate, including the selective alcoholysis of a betulin-3,28-diester, e.g., betulin-3,28-diacetate; a method for preparing betulin-3-acetate including (1) acetylating betulin to provide betulin-3,28-diacetate and (2) the alcoholysis of betulin-3,28-diacetate to provide betulin-3-acetate; a method for preparing betulinic acid from betulin-3-acetate including (1) acetylating betulin to provide betulin-3,28-diacetate, (2) the alcoholysis of betulin-3,28-diacetate to provide betulin-3-acetate, (3) oxidizing betulin-3-acetate to provide betulinic aldehyde-3-acetate, (4) oxidizing betulinic aldehyde-3-acetate to provide betulinic acid-3-acetate, and (5) deprotecting betulinic acid-3-acetate to provide betulinic acid.

摘要翻译： 本发明提供了在3-位上制备桦木醇酯的方法，例如桦木醇-3-乙酸酯，包括桦木醇-3,28-二酯如桦木醇-2,28-二乙酸酯的选择性醇解; 一种制备桦木素-3-乙酸酯的方法，包括（1）乙酰化桦木醇以提供桦木醇-3,28-二乙酸酯和（2）桦木醇-2,38-二乙酸酯的醇解以提供桦木醇-3-乙酸酯; 一种从桦木醇-3-乙酸酯制备桦木酸的方法，包括（1）乙酰化桦木醇以提供桦木醇-2,38-二乙酸酯，（2）桦木醇-3,28-二乙酸酯的醇解以提供桦木醇-3-乙酸酯（ 3）氧化桦木酸-3-乙酸酯以提供桦木醛-3-乙酸酯，（4）氧化桦木醛-3-乙酸酯以提供桦木酸-3-乙酸酯，和（5）脱保护桦木酸-3-乙酸酯以提供桦木酸 酸。

公开(公告)号：US06392070B1

公开(公告)日：2002-05-21

申请号：US09371298

申请日：1999-08-10

申请人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Vitaliy V. Nesterenko

发明人： Pavel A. Krasutsky ,  Robert M. Carlson ,  Vitaliy V. Nesterenko

IPC分类号： C07J900

CPC分类号： C07D303/38 ,  C07C29/86 ,  C07C51/367 ,  C07C51/43 ,  C07C59/01 ,  C07C59/105 ,  C07J63/008 ,  D21B1/023 ,  C07C31/10 ,  C07C31/08 ,  C07C31/04

摘要： The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.

公开(公告)号：US08013078B2

公开(公告)日：2011-09-06

申请号：US12637605

申请日：2009-12-14

申请人： Shenggao Liu ,  Robert M. Carlson ,  Jeremy E. Dahl

发明人： Shenggao Liu ,  Robert M. Carlson ,  Jeremy E. Dahl

IPC分类号： C08F20/00

CPC分类号： C07C49/617 ,  C07C23/20 ,  C07C49/423 ,  C07C49/613 ,  C07C61/29 ,  C07D221/22 ,  C07D311/96 ,  C07D313/06 ,  C07D335/04 ,  C07D471/10 ,  C07F9/65683

摘要： This invention is related to heteroatom containing diamondoids (i.e., “heterodiamondoids”) which are compounds having a diamondoid nucleus in which one or more of the diamondoid nucleus carbons has been substitutionally replaced with a noncarbon atom. These heteroatom substituents impart desirable properties to the diamondoid. In addition, the heterodiamondoids are functionalized affording compounds carrying one or more functional groups covalently pendant therefrom. This invention is further related to polymerizable functionalized heterodiamondoids. In a preferred aspect of this invention the diamondoid nuclei are triamantane and higher diamondoid nuclei. In another preferred aspect, the heteroatoms are selected to give rise to diamondoid materials which can serve as n- and p-type materials in electronic devices can serve as optically active materials.

公开(公告)号：US07981975B2

公开(公告)日：2011-07-19

申请号：US12637621

申请日：2009-12-14

申请人： Shenggao Liu ,  Robert M. Carlson ,  Jeremy E. Dahl

发明人： Shenggao Liu ,  Robert M. Carlson ,  Jeremy E. Dahl

IPC分类号： C08F20/00

CPC分类号： C07C49/617 ,  C07C23/20 ,  C07C49/423 ,  C07C49/613 ,  C07C61/29 ,  C07D221/22 ,  C07D311/96 ,  C07D313/06 ,  C07D335/04 ,  C07D471/10 ,  C07F9/65683

摘要： This invention is related to heteroatom containing diamondoids (i.e., “heterodiamondoids”) which are compounds having a diamondoid nucleus in which one or more of the diamondoid nucleus carbons has been substitutionally replaced with a noncarbon atom. These heteroatom substituents impart desirable properties to the diamondoid. In addition, the heterodiamondoids are functionalized affording compounds carrying one or more functional groups covalently pendant therefrom. This invention is further related to polymerizable functionalized heterodiamondoids. In a preferred aspect of this invention the diamondoid nuclei are triamantane and higher diamondoid nuclei. In another preferred aspect, the heteroatoms are selected to give rise to diamondoid materials which can serve as n- and p-type materials in electronic devices can serve as optically active materials.

摘要翻译： 本发明涉及含杂原子的类金刚石（即“异二亚类”），它们是具有金刚石核的化合物，其中一个或多个金刚石核碳原子被替代为非碳原子。 这些杂原子取代基赋予金刚石所需的性质。 此外，异二亚甲基二羧酸被官能化，从而提供携带一个或多个共价悬挂的官能团的化合物。 本发明进一步涉及可聚合的官能化异二聚体。 在本发明的优选方面，金刚石核是三金刚烷和更高的金刚石核。 在另一个优选的方面，选择这些杂原子以产生可用作电子器件中的n-型和p-型材料的类金刚石材料，可用作光学活性材料。

公开(公告)号：US20100190985A1

公开(公告)日：2010-07-29

申请号：US12637621

申请日：2009-12-14

申请人： Shenggao Liu ,  Robert M. Carlson ,  Jeremy E. Dahl

发明人： Shenggao Liu ,  Robert M. Carlson ,  Jeremy E. Dahl

IPC分类号： C07C13/615 ,  C07D221/18 ,  C07D311/02 ,  C07C203/00 ,  C07C69/74 ,  C07C61/12 ,  C07C233/10 ,  C07C211/16 ,  C07C49/313 ,  C07C43/18 ,  C07C23/18

CPC分类号： C07C49/617 ,  C07C23/20 ,  C07C49/423 ,  C07C49/613 ,  C07C61/29 ,  C07D221/22 ,  C07D311/96 ,  C07D313/06 ,  C07D335/04 ,  C07D471/10 ,  C07F9/65683

摘要： This invention is related to heteroatom containing diamondoids (i.e., “heterodiamondoids”) which are compounds having a diamondoid nucleus in which one or more of the diamondoid nucleus carbons has been substitutionally replaced with a noncarbon atom. These heteroatom substituents impart desirable properties to the diamondoid. In addition, the heterodiamondoids are functionalized affording compounds carrying one or more functional groups covalently pendant therefrom. This invention is further related to polymerizable functionalized heterodiamondoids. In a preferred aspect of this invention the diamondoid nuclei are triamantane and higher diamondoid nuclei. In another preferred aspect, the heteroatoms are selected to give rise to diamondoid materials which can serve as n- and p-type materials in electronic devices can serve as optically active materials.

摘要翻译： 本发明涉及含杂原子的类金刚石（即“异二亚类”），它们是具有金刚石核的化合物，其中一个或多个金刚石核碳原子被替代为非碳原子。 这些杂原子取代基赋予金刚石所需的性质。 此外，异二亚甲基二羧酸被官能化，从而提供携带一个或多个共价悬挂的官能团的化合物。 本发明进一步涉及可聚合的官能化异二聚体。 在本发明的优选方面，金刚石核是三金刚烷和更高的金刚石核。 在另一个优选的方面，选择这些杂原子以产生可用作电子器件中的n-型和p-型材料的类金刚石材料，可用作光学活性材料。