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公开(公告)号：US07347843B2
公开(公告)日：2008-03-25
申请号：US11190789
申请日：2005-07-26
IPC分类号： A61M31/00
CPC分类号： A61M39/0208 , A61M5/158 , A61M5/16831 , A61M2039/0226 , A61M2039/0244
摘要： A vascular access port system including means for detecting and indicating the presence or absence of a needle. The detecting and indicating means may be carried in whole or in part by one of or both of the needle and/or the vascular access port. The detecting and indicating means may utilize a conductive needle, a mechanical switch, a magnetic switch, a Hall effect sensor, an electric field, a magnetic field, or an inductor, for example, for detection purposes. The vascular access port system permits the practitioner to confirm that the needle has been correctly inserted into the VAP, and notifies the patient and/or practitioner if the needle has been accidentally withdrawn.
摘要翻译： 一种血管通路系统，包括用于检测和指示针的存在或不存在的装置。 检测和指示装置可以全部或部分地由针和/或血管进入口中的一个或两个承载。 检测和指示装置可以使用导电针，机械开关，磁开关，霍尔效应传感器，电场，磁场或电感器，例如用于检测目的。 血管通路系统允许从业者确认针已被正确地插入到VAP中，并且如果针被意外地取出，则通知患者和/或从业者。
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公开(公告)号：US06296615B1
公开(公告)日：2001-10-02
申请号：US09264147
申请日：1999-03-05
IPC分类号： A61B502
摘要： The disclosed embodiments present improved catheters with physiological sensors. In one embodiment, the catheter includes, generally, a pressure transducer/electronics assembly connected to a pressure transmission catheter. The pressure transmission catheter includes a hollow tube made from a low compliance material. The distal end of the hollow tube is filled with a gel-like material or plug which acts as a barrier between the catheter liquid and the target fluid. The hollow tube is partially filled with a low viscosity liquid and is in fluid communication with the gel-like material and the pressure transducer. The pressure of the target fluid is transmitted to the liquid in the hollow tube through the gel-like material and/or the wall of the distal tip and is fluidically transmitted to the pressure transducer. The pressure transmission catheter is capable of being inserted into a vessel lumen or inserted into a lumen of a therapeutic or diagnostic catheter for biomedical applications. This provides the ability to directly measure the pressure effects of the treatment catheter. In another embodiment, the distal end of the pressure transmission catheter may be electrically conductive so as to detect and transmit an electric signal. Thus, in this embodiment, the catheter can be used to detect a physiological signal.
摘要翻译： 所公开的实施例使用生理传感器呈现改进的导管。 在一个实施例中，导管通常包括连接到压力传递导管的压力传感器/电子组件。 压力传递导管包括由低顺应性材料制成的中空管。 中空管的远端填充有凝胶状材料或塞子，其作为导管液体和目标流体之间的屏障。 中空管部分地填充有低粘度液体并与凝胶状材料和压力传感器流体连通。 目标流体的压力通过凝胶状材料和/或远侧末端的壁传递到中空管中的液体，并且被流体传递到压力传感器。 压力传递导管能够插入血管内腔或插入用于生物医学应用的治疗或诊断导管的内腔中。 这提供了直接测量治疗导管的压力作用的能力。 在另一个实施例中，压力传输导管的远端可以是导电的，以便检测和传输电信号。 因此，在本实施例中，导管可用于检测生理信号。
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13.发明授权
公开(公告)号：US4796641A
公开(公告)日：1989-01-10
申请号：US69728
申请日：1987-07-06
申请人： Perry A. Mills , Brian P. Brockway
发明人： Perry A. Mills , Brian P. Brockway
IPC分类号： A61B5/0215 , A61B5/07 , A61B5/00
CPC分类号： A61B5/076 , A61B5/0215 , Y10S128/13 , Y10S128/903
摘要： A device capable of sensing pressure allows the sensor and amplifying electronics to be packaged in a very small size and implanted within the body. The sensor consists of a small catheter, the tip of which is placed at the point at which pressure is to be measured, attached to a solid-state pressure sensor. The catheter is filled with a fluid and is connected to an implantable infusion pump which dispenses through the lumen of the catheter, heparin or other drug which inhibits thrombogenisis.
摘要翻译： 能够感测压力的装置允许将传感器和放大电子装置以非常小的尺寸包装并植入体内。 传感器由一个小导管组成，其小尖端被放置在要测量的压力点上，连接到固态压力传感器。 导管填充有流体并且连接到可植入输液泵，其通过导管的内腔，肝素或其它抑制血栓形成的药物而分配。
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14.发明授权Pacemaker with adaptive sensing means for use with unipolar or bipolar leads 失效起搏器具有用于单极或双极引线的自适应感测装置
公开(公告)号：US4532931A
公开(公告)日：1985-08-06
申请号：US626525
申请日：1984-06-29
申请人： Perry A. Mills
发明人： Perry A. Mills
CPC分类号： A61N1/056 , A61N1/365 , Y10S128/902
摘要： A sensing circuit for a cardiac stimulator which can adapt to the use therewith of either bipolar leads or unipolar leads without the need for telemetric programming of a switch internal to the implanted pacemaker. If a unipolar lead is plugged into the terminal receptacle of the pacer at the time of implant, the pacer will sense R-wave activity and other artifacts between a distal tip electrode and the metal body of the pacemaker, but if a bipolar lead is plugged into that same receptacle at the time of implant, the pacer will sense such artifacts between a tip electrode and a ring electrode spaced a predetermined short distance proximally of the tip electrode along the surface of the lead body.
摘要翻译： 用于心脏刺激器的感测电路，其可以适应于双极引线或单极引线的使用，而不需要对植入式起搏器内部的开关进行遥测编程。 如果在植入时将单极引线插入到起搏器的端子插座中，则起搏器将感测远端尖端电极与起搏器的金属体之间的R波活动和其他伪影，但是如果双极引线被插入 在植入时入射到相同的容器中，起搏器将感测尖端电极和环形电极之间的这种假象，该尖端电极和环形电极沿着引线体的表面在尖端电极的近侧间隔预定的短距离。
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公开(公告)号：US4298007A
公开(公告)日：1981-11-03
申请号：US170948
申请日：1980-07-21
CPC分类号： A61N1/368
摘要： An electrical pacer device which responds to cardiac demand so as to alter the cardiac output in a fashion to satisfy that demand. Changes in the fundamental period of the atrial electrical cycle are detected and averaged over a predetermined time interval and the resulting control signal is used to raise and lower the ventricular heart rate to increase and decrease the aforesaid cardiac output. At the same time, means are provided for continuously driving the ventricular rate toward a predetermined lower rate (the at rest rate) on a time cycle which is significantly longer than the above-mentioned predetermined time interval.
摘要翻译： 一种响应于心脏需求以便以满足该需求的方式改变心输出量的电子起搏装置。 在预定时间间隔内检测和平均心房电循环的基本周期的变化，并且使用所得到的控制信号来提高和降低心室心率以增加和减少上述心输出量。 同时，提供了用于在明显长于上述预定时间间隔的时间周期上将心室率持续地驱动到预定的较低速率（静止时）的装置。
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公开(公告)号：US20130012800A1
公开(公告)日：2013-01-10
申请号：US13613419
申请日：2012-09-13
申请人： Brian P. Brockway , Perry A. Mills
发明人： Brian P. Brockway , Perry A. Mills
IPC分类号： A61B5/042
CPC分类号： A61B5/686 , A61B5/0031 , A61B5/042 , A61B5/0422 , A61B5/076 , A61B5/7232 , A61B2560/0219 , A61B2560/063 , A61B2560/066 , A61B2562/0209 , A61B2562/164 , A61B2562/18 , A61N1/0504 , A61N1/37229 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： An implantable monitoring device includes a flexible lead body that includes at least one sensing element. The device also includes a rigid main body connected to the flexible lead body at an attachment point. The rigid main body is generally centered about a longitudinal axis defined by the flexible lead body when the lead body is unflexed. The device further includes a measurement circuit, which is housed within the rigid main body and electrically coupled to the at least one sensing element of the flexible lead body and at least another sensing element on an outside surface of the rigid main body. The measurement circuit is configured to measure a potential difference between the at least one sensing element of the flexible lead body and the at least another sensing element of the main body.
摘要翻译： 可植入监测装置包括一个包括至少一个传感元件的柔性引线体。 该装置还包括在附接点处连接到柔性引线主体的刚性主体。 当铅体未折叠时，刚性主体通常由柔性引线体限定的纵向轴线对准。 该装置还包括测量电路，该测量电路容纳在刚性主体内并且电耦合到柔性引线本体的至少一个感测元件以及刚性主体的外表面上的至少另一个感测元件。 测量电路被配置为测量柔性引线体的至少一个感测元件与主体的至少另一感测元件之间的电位差。
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公开(公告)号：US20080275312A1
公开(公告)日：2008-11-06
申请号：US12172928
申请日：2008-07-14
申请人： Oleg F. Mosesov , Perry A. Mills
发明人： Oleg F. Mosesov , Perry A. Mills
IPC分类号： A61B5/00
CPC分类号： A61B5/0006 , A61B5/0031 , A61N1/37235 , A61N1/37276 , A61N1/3787 , H04W74/08
摘要： An ambulatory monitoring device includes a sensor to monitor a physiological signal and a battery power source. The device also includes a wireless receiver adapted to monitor a first frequency band having frequencies below 1 MHz and configured to detect and receive, using less than 10 micro-amps of current from the battery power source when operating, wireless communications within the first frequency band from a remote device at least one meter away. The device further includes a wireless transmitter adapted to transmit—after receipt from the remote device of a first wireless communication within the first frequency band that includes an invitation for further communication—a second wireless communication in a second frequency band having frequencies above 10 MHz, the second wireless communication comprising data indicative of the physiological signal as sensed by the sensor.
摘要翻译： 移动监视装置包括用于监测生理信号的传感器和电池电源。 该设备还包括无线接收器，其适于监测频率低于1MHz的第一频带并被配置为在操作时使用来自电池电源的小于10微安的电流来检测和接收第一频带内的第一频带内的无线通信 从远程设备至少一米远。 所述设备还包括适于在从所述远程设备接收到所述第一频带内的包括进一步通信的邀请的第一无线通信之后发送的无线发射机 - 在频率高于10MHz的第二频带中的第二无线通信， 第二无线通信包括指示由传感器感测的生理信号的数据。
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公开(公告)号：US4562841A
公开(公告)日：1986-01-07
申请号：US405711
申请日：1982-08-05
申请人： Brian P. Brockway , Robert D. Dreher , Daniel E. Huntwork , Brock S. Lindstedt , Douglas C. Morrison , Perry A. Mills
发明人： Brian P. Brockway , Robert D. Dreher , Daniel E. Huntwork , Brock S. Lindstedt , Douglas C. Morrison , Perry A. Mills
CPC分类号： A61N1/37252 , A61N1/3622 , A61N1/368 , A61N1/3688 , A61N1/37223
摘要： A programmable cardiac pacemaker that is selectively programmable via a radio frequency communications link into one of a plurality of a single and dual chamber pacing modes. Depending upon the mode selected, an associated plurality of pacing parameters may be programmed, each within a predetermined range of possible magnitudes.The pacemaker includes a rate smoothing function for preventing the rate interval from changing by more than a predetermined percentage on a cycle-to-cycle basis; and a graceful degradation function for causing the ventricular pacing rate to decay when the atrial rate exceeds a programmed upper rate limit for a predetermined length of time. A graceful degration onset time and rate of decay are also programmable. Additionally, the pacemaker contains a set of pre-programmed alternative pacing parameters for at least one mode and which can be independently reverted to.The pacemaker control circuitry is organized about a central bus into an I/O controller and a pacing controller. Pacing control is continuous and its I/O communications operate on a prioritized basis. I/O control permits the programming of any register and the interrogation of a variety of analog parameters associated therewith.
摘要翻译： 一种可编程的心脏起搏器，其可经由射频通信链路选择性地编程为多个单室起搏模式和双室起搏模式之一。 根据所选择的模式，相关联的多个起搏参数可以被编程，每个在可能的幅度的预定范围内。 起搏器包括速率平滑功能，用于在循环到循环的基础上防止速率间隔改变超过预定百分比; 以及当心房速率超过编程的上限速度达预定时间长度时，使心室起搏速率衰减的优雅降解功能。 优雅的降级开始时间和衰减速率也是可编程的。 此外，起搏器包含一组用于至少一种模式的预先编程的替代起搏参数，并且可以独立地还原。 将起搏器控制电路组织为一个中央总线到I / O控制器和起搏控制器中。 起搏控制是连续的，其I / O通信以优先级为基础进行操作。 I / O控制允许编程任何寄存器和询问与之相关的各种模拟参数。
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公开(公告)号：US09198591B2
公开(公告)日：2015-12-01
申请号：US13613419
申请日：2012-09-13
申请人： Brian P. Brockway , Perry A. Mills
发明人： Brian P. Brockway , Perry A. Mills
CPC分类号： A61B5/686 , A61B5/0031 , A61B5/042 , A61B5/0422 , A61B5/076 , A61B5/7232 , A61B2560/0219 , A61B2560/063 , A61B2560/066 , A61B2562/0209 , A61B2562/164 , A61B2562/18 , A61N1/0504 , A61N1/37229 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： An implantable monitoring device includes a flexible lead body that includes at least one sensing element. The device also includes a rigid main body connected to the flexible lead body at an attachment point. The rigid main body is generally centered about a longitudinal axis defined by the flexible lead body when the lead body is unflexed. The device further includes a measurement circuit, which is housed within the rigid main body and electrically coupled to the at least one sensing element of the flexible lead body and at least another sensing element on an outside surface of the rigid main body. The measurement circuit is configured to measure a potential difference between the at least one sensing element of the flexible lead body and the at least another sensing element of the main body.
摘要翻译： 可植入监测装置包括一个包括至少一个传感元件的柔性引线体。 该装置还包括在附接点处连接到柔性引线主体的刚性主体。 当铅体未折叠时，刚性主体通常由柔性引线体限定的纵向轴线对准。 该装置还包括测量电路，该测量电路容纳在刚性主体内并且电耦合到柔性引线本体的至少一个感测元件以及刚性主体的外表面上的至少另一个感测元件。 测量电路被配置为测量柔性引线体的至少一个感测元件与主体的至少另一感测元件之间的电位差。
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公开(公告)号：US08660659B2
公开(公告)日：2014-02-25
申请号：US13548819
申请日：2012-07-13
申请人： Oleg F. Mosesov , Perry A. Mills
发明人： Oleg F. Mosesov , Perry A. Mills
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61B5/0031 , A61N1/37235 , A61N1/3787 , H04W74/08
摘要： An ambulatory monitoring device includes a sensor to monitor a physiological signal and a battery power source. The device also includes a wireless receiver adapted to monitor a first frequency band having frequencies below 1 MHz and configured to detect and receive, using less than 10 micro-amps of current from the battery power source when operating, wireless communications within the first frequency band from a remote device at least one meter away. The device further includes a wireless transmitter adapted to transmit—after receipt from the remote device of a first wireless communication within the first frequency band that includes an invitation for further communication—a second wireless communication in a second frequency band having frequencies above 10 MHz, the second wireless communication comprising data indicative of the physiological signal as sensed by the sensor.
摘要翻译： 移动监视装置包括用于监测生理信号的传感器和电池电源。 该设备还包括无线接收器，其适于监测频率低于1MHz的第一频带并被配置为在操作时使用来自电池电源的小于10微安的电流来检测和接收第一频带内的第一频带内的无线通信 从远程设备至少一米远。 所述设备还包括适于在从所述远程设备接收到所述第一频带内的包括进一步通信的邀请的第一无线通信之后发送的无线发射机 - 在频率高于10MHz的第二频带中的第二无线通信， 第二无线通信包括指示由传感器感测的生理信号的数据。
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