公开(公告)号：US09668068B2

公开(公告)日：2017-05-30

申请号：US13172980

申请日：2011-06-30

申请人： Michael A. Faltys ,  Abhijit Kulkarni ,  Scott A. Crawford

发明人： Michael A. Faltys ,  Abhijit Kulkarni ,  Scott A. Crawford

IPC分类号： H04R25/00

CPC分类号： H04R25/407 ,  H04R25/606

摘要： A system and method for generating a beamforming signal is disclosed. A beam forming signal is generated by disposing a first microphone and a second microphone in horizontal coplanar alignment. The first and second microphones are used to detect a known signal to generate a first response and a second response. The first response is processed along a first signal path communicatively linked to the first microphone, and the second response is processed along a second signal path communicatively linked to the second microphone. The first and second responses are matched, and the matched responses are combined to generate the beamforming signal on a combined signal path.

公开(公告)号：US20160096016A1

公开(公告)日：2016-04-07

申请号：US14967149

申请日：2015-12-11

申请人： Kevin J. TRACEY ,  Mauricio ROSAS-BALLINA ,  Michael A. FALTYS ,  Ralph J. ZITNIK

发明人： Kevin J. TRACEY ,  Mauricio ROSAS-BALLINA ,  Michael A. FALTYS ,  Ralph J. ZITNIK

IPC分类号： A61N1/36 ,  A61N1/32

CPC分类号： A61N1/327 ,  A61N1/326 ,  A61N1/36053 ,  A61N1/36071

摘要： Described herein are devices, systems and method of treating inflammation by vagus nerve stimulation and the delivery of an anti-inflammatory drug. In particular, described herein are methods of treating inflammation including the steps of stimulating a subject's inflammatory reflex to inhibit the immune response and administering an anti-inflammatory drug.

摘要翻译： 本文描述了通过迷走神经刺激和递送抗炎药治疗炎症的装置，系统和方法。 特别地，本文描述了治疗炎症的方法，包括刺激受试者的炎性反射以抑制免疫应答和施用抗炎药的步骤。

公开(公告)号：US08996116B2

公开(公告)日：2015-03-31

申请号：US12917197

申请日：2010-11-01

申请人： Michael A. Faltys ,  Jacob A. Levine

发明人： Michael A. Faltys ,  Jacob A. Levine

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36053 ,  A61N1/0551 ,  A61N1/36071

摘要： Methods and devices for the treatment of chronic pain by modulation of the cholinergic anti-inflammatory pathway. In particular, the methods and systems described herein may be used to enhance chronic pain therapies such as spinal cord stimulation (SCS). Thus, the present invention describes devices and methods for modulation of the cytokine pathway by stimulation of the neuronal cholinergic anti-inflammatory pathway (NCAP) to enhance the treatment of chronic pain by SCS. The use of NCAP in conjunction with SCS may potentiate the effects of SCS and/or prevent the desensitization of the patient to SCS.

摘要翻译： 通过调节胆碱能消炎途径治疗慢性疼痛的方法和装置。 特别地，本文描述的方法和系统可用于增强慢性疼痛疗法，例如脊髓刺激（SCS）。 因此，本发明描述了通过刺激神经元胆碱能抗炎通路（NCAP）来调节细胞因子途径以增强SCS治疗慢性疼痛的装置和方法。 使用NCAP与SCS联合可以增强SCS的作用和/或预防患者对SCS的脱敏。

公开(公告)号：US20110054569A1

公开(公告)日：2011-03-03

申请号：US12874171

申请日：2010-09-01

申请人： Ralph J. ZITNIK ,  Michael A. Faltys

发明人： Ralph J. ZITNIK ,  Michael A. Faltys

IPC分类号： A61N1/08 ,  A61N1/36

CPC分类号： A61N1/08 ,  A61N1/372 ,  A61N1/37247

摘要： Described herein are devices, including interface modules or prescription pads, and systems including these devices and methods of using them, for treating inflammation or inflammatory disorders, and particularly for interfacing with a user desiring to prescribe treatment of an inflammatory disorder using an implanted stimulator.

摘要翻译： 本文描述的是包括界面模块或处方垫的装置，以及包括这些装置的系统和使用它们的方法，用于治疗炎症或炎症性疾病的装置，特别是与期望使用植入的刺激器开放治疗炎性病症的用户接口的装置。

公开(公告)号：US20100125304A1

公开(公告)日：2010-05-20

申请号：US12620413

申请日：2009-11-17

申请人： Michael A. Faltys

发明人： Michael A. Faltys

IPC分类号： A61N1/08

CPC分类号： A61N1/36135 ,  A61N1/36053 ,  A61N1/36132

摘要： Described herein are methods, devices and system for selecting an optimum position of a stimulation electrode, and particularly methods, devices and systems for optimizing the position of a stimulation electrode for stimulating the inflammatory reflex and thereby inhibiting inflammation. The methods, devices and systems described herein may generally include the analysis of one or more artifact modalities arising after the application of a stimulation pulse. One or more of these artifact modalities (e.g., EMG, ECG, etc.) may be detected and used to generate a comparable indicator of the fitness of the position of the electrode relative to a target, such as a portion of the inflammatory reflex like the vagus nerve.

摘要翻译： 这里描述了用于选择刺激电极的最佳位置的方法，装置和系统，特别是用于优化刺激电极的位置以刺激炎症反射从而抑制炎症的方法，装置和系统。 本文描述的方法，装置和系统通常可以包括在施加刺激脉冲之后产生的一个或多个伪影模态的分析。 可以检测这些工件模态（例如，EMG，ECG等）中的一种或多种，​​并用于产生电极相对于靶的适应度的可比指示，例如炎症反射的一部分，例如 迷走神经。

公开(公告)号：US07636603B1

公开(公告)日：2009-12-22

申请号：US11428302

申请日：2006-06-30

申请人： Edward H Overstreet ,  Michael A Faltys

发明人： Edward H Overstreet ,  Michael A Faltys

IPC分类号： A61N1/36

CPC分类号： A61N1/36036 ,  A61N1/0541

摘要： A bionic ear cochlear stimulation system has the capability to stimulate fast enough to induce stochastic neural firing, thereby acting to restore “spontaneous” neural activity. Such neurostimulation involves the use of a high rate pulsitile stimulation signal that is amplitude modulated with sound information. Advantageously, by using such neurostimulation, a fitting system may be utilized that does not normally require T-level threshold measurements. T-level threshold measurements are not required in most instances because the high-rate pulsitile stimulation, even though at levels that would normally be a sub-threshold electrical stimulus, is able to modulate neural firing patterns in a perceptible way.

摘要翻译： 仿生耳蜗耳刺激系统具有刺激足够快以诱导随机神经发射的能力，从而起到恢复“自发”神经活动的作用。 这种神经刺激涉及使用用声音信息进行幅度调制的高速率脉动刺激信号。 有利地，通过使用这种神经刺激，可以采用通常不需要T级阈值测量的拟合系统。 在大多数情况下，不需要T级阈值测量，因为即使在通常为亚阈值电刺激的水平下，高速率脉动刺激能够以可察觉的方式调节神经发射模式。

公开(公告)号：US07561920B2

公开(公告)日：2009-07-14

申请号：US11097611

申请日：2005-03-31

申请人： Michael A. Faltys ,  Philip A. Segel ,  Edward H. Overstreet ,  William Vanbrooks Harrison

发明人： Michael A. Faltys ,  Philip A. Segel ,  Edward H. Overstreet ,  William Vanbrooks Harrison

IPC分类号： A61N1/18

CPC分类号： H04R25/70 ,  A61N1/36036

摘要： Methods and systems for modifying the parameters of at least one hearing device for a patient with residual hearing provide needed orchestration of acoustic and electric stimulation of patients wearing such devices.

摘要翻译： 用于修改具有残留听力的患者的至少一个听力装置的参数的方法和系统为佩戴这种装置的患者提供对声学和电刺激的所需编排。

公开(公告)号：US07450994B1

公开(公告)日：2008-11-11

申请号：US11016604

申请日：2004-12-16

申请人： Lakshmi Narayan Mishra ,  Michael A. Faltys

发明人： Lakshmi Narayan Mishra ,  Michael A. Faltys

IPC分类号： A61N1/00

CPC分类号： A61B5/442 ,  A61N1/0541 ,  A61N1/08 ,  A61N1/36036

摘要： A flap thickness measurement system includes a reference cochlear stimulation system. The reference cochlear stimulation system includes a sound processor, a transmitter that transmits a telemetric signal, and a cochlear stimulator having a receiver that receives the telemetric signal and transmits a signal back to the transmitter. The system further includes one or more flap simulators having one or more known thicknesses that is positioned between the transmitter and receiver. Also included is a microprocessor that receives and processes data representative of tank voltage from the reference cochlear stimulation system.

摘要翻译： 皮瓣厚度测量系统包括参考耳蜗刺激系统。 参考耳蜗刺激系统包括声音处理器，发送遥测信号的发射器和具有接收遥测信号并将信号发送回发射机的耳蜗刺激器。 该系统还包括具有一个或多个已知厚度的一个或多个折翼模拟器，其位于发射器和接收器之间。 还包括微处理器，其接收并处理来自参考耳蜗刺激系统的代表罐电压的数据。

公开(公告)号：US20080221640A1

公开(公告)日：2008-09-11

申请号：US10698097

申请日：2003-10-31

申请人： Edward H. Overstreet ,  Leonid M. Litvak ,  Michael A. Faltys

发明人： Edward H. Overstreet ,  Leonid M. Litvak ,  Michael A. Faltys

IPC分类号： A61N1/00

CPC分类号： A61N1/37247 ,  A61N1/36036

摘要： A multichannel neurostimulation device spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.

摘要翻译： 多通道神经刺激装置通过以下方式之一将目标神经组织中的激发图案空间扩展：（1）快速连续刺激小组电极，或（2）同时刺激小组电极。 这种多电极刺激以同步方式刺激更多数量的神经元，从而增加细胞外电压波动的幅度并促进其记录。 电刺激同时（或以快速顺序）施加在选定的小组电极上，同时监测附近电极上的诱发化合物动作电位（ECAP）。 可观察到的ECAP的存在不仅在患者无意识或不能提供主观反馈的时候验证植入装置的操作，而且还提供了将所观察到的ECAP的大小记录为作为 施加的刺激的幅度。 从该数据可以获得安全，有效和舒适的阈值水平，其可以随后用作神经刺激装置的刺激参数的初始设置，或者指导神经刺激装置的刺激参数的设置。

公开(公告)号：US06308101B1

公开(公告)日：2001-10-23

申请号：US09404966

申请日：1999-09-24

申请人： Michael A. Faltys ,  Janusz A. Kuzma ,  John C. Gord

发明人： Michael A. Faltys ,  Janusz A. Kuzma ,  John C. Gord

IPC分类号： A61N136

CPC分类号： A61N1/08 ,  A61N1/36036 ,  A61N1/375 ,  A61N1/3787

摘要： A fully implantable cochlear implant system (170) and method includes an implantable cochlear stimulator (ICS) unit (212) that is connected to an implantable speech processor (ISP) unit (210). Both the ISP unit and the ICS unit reside in separate, hermetically-sealed, cases. The ICS unit has a coil (220) permanently connected thereto through which magnetic or inductive coupling may occur with a similar coil located externally during recharging, programming, or externally-controlled modes of operation. The ICS unit further has a cochlear electrode array (114) permanently connected thereto via a first multi-conductor cable (116). The ICS unit 212 also has a second multi-conductor cable (222) attached thereto, which second cable contains no more than five conductors. The second cable is detachably connected to the ISP unit via a connector (224) located on the case of the ISP unit. The ISP unit includes an implantable subcutaneous microphone (218) as an integral part thereof, and further includes ISP circuitry (214) and a replenishable power source (216), e.g., a rechargeable battery.

摘要翻译： 完全植入式人工耳蜗植入系统（170）和方法包括连接到可植入语音处理器（ISP）单元（210）的可植入人工耳蜗刺激器（ICS）单元（212）。 ISP单元和ICS单元均位于单独的密封的情况下。 ICS单元具有永久连接到其上的线圈（220），通过该线圈可以在再充电，编程或外部控制的操作模式期间与位于外部的类似线圈发生磁耦合或电感耦合。 ICS单元还具有经由第一多导体电缆（116）永久地连接到其上的耳蜗电极阵列（114）。 ICS单元212还具有附接到其上的第二多导体电缆（222），该第二电缆包含不超过五个导体。 第二电缆通过位于ISP单元壳体上的连接器（224）可拆卸地连接到ISP单元。 ISP单元包括可植入式皮下麦克风（218）作为其整体部分，并且还包括ISP电路（214）和可补充电源（216），例如可再充电电池。