Microfluidic device and uses thereof
    14.
    发明授权
    Microfluidic device and uses thereof 有权
    微流体装置及其用途

    公开(公告)号:US09156037B2

    公开(公告)日:2015-10-13

    申请号:US13144572

    申请日:2010-01-15

    Abstract: A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

    Abstract translation: 用于从源流体分离目标部件的微流体装置包括通过一个或多个传送通道连接到一个或多个收集通道的一个或多个源通道。 源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体,使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括滞留的收集流体,直到预处理的体积的源流体被处理或预定量的目标组分积聚在收集通道中,此时收集流体可被泵入收集通道以冲洗目标组分 离开收集渠道。 随后分析目标成分进行检测和诊断。

    Temperature-gradient cancelation technique and device
    16.
    发明授权
    Temperature-gradient cancelation technique and device 有权
    温度梯度消除技术和装置

    公开(公告)号:US07862229B2

    公开(公告)日:2011-01-04

    申请号:US12229525

    申请日:2008-08-22

    CPC classification number: G01K3/14 G01P15/008

    Abstract: A system, device, and method for minimizing x-axis and/or y-axis offset shift due to internally produced as well as externally produced on chip temperature imbalances. At least one temperature gradient canceling device is disposed on a substrate including a temperature gradient sensitive device having at least one pair of sensors. Voltage signals generated by the temperature gradient canceling devices can be combined with voltage signals generated by each of the pair of sensors to account for the offset.

    Abstract translation: 用于最小化由于内部产生的x轴和/或y轴偏移偏移以及外部产生的片上温度失衡的系统,装置和方法。 至少一个温度梯度消除装置设置在包括具有至少一对传感器的温度梯度敏感装置的基板上。 由温度梯度消除装置产生的电压信号可与由该对传感器中的每一个生成的电压信号组合以考虑偏移。

    Temperature-gradient cancelation technique and device
    17.
    发明申请
    Temperature-gradient cancelation technique and device 有权
    温度梯度消除技术和装置

    公开(公告)号:US20100045362A1

    公开(公告)日:2010-02-25

    申请号:US12229525

    申请日:2008-08-22

    CPC classification number: G01K3/14 G01P15/008

    Abstract: A system, device, and method for minimizing x-axis and/or y-axis offset shift due to internally produced as well as externally produced on chip temperature imbalances. At least one temperature gradient canceling device is disposed on a substrate including a temperature gradient sensitive device having at least one pair of sensors. Voltage signals generated by the temperature gradient canceling devices can be combined with voltage signals generated by each of the pair of sensors to account for the offset.

    Abstract translation: 用于最小化由于内部产生的x轴和/或y轴偏移偏移以及外部产生的片上温度失衡的系统,装置和方法。 至少一个温度梯度消除装置设置在包括具有至少一对传感器的温度梯度敏感装置的基板上。 由温度梯度消除装置产生的电压信号可以与由一对传感器中的每一个生成的电压信号相组合以考虑偏移。

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