公开(公告)号：US06643589B2

公开(公告)日：2003-11-04

申请号：US10091310

申请日：2002-03-05

申请人： Zhiyi Zhang ,  Liming Yu ,  Leonty Abraham Tabarovsky ,  Berthold Kriegshauser

发明人： Zhiyi Zhang ,  Liming Yu ,  Leonty Abraham Tabarovsky ,  Berthold Kriegshauser

IPC分类号： G01V318

CPC分类号： G01V3/28

摘要： Measurements made by a multicomponent logging tool in a borehole are inverted to obtain horizontal and vertical resistivities and formation dip and azimuth angles of a formation traversed by the borehole. The inversion is performed using a generalized Marquardt-Levenberg method. In this generalized Marquardt-Levenberg method, a data objective function is defined that is related to a difference between the model output and the measured data. The iterative procedure involves reducing a global objective function that is the sum of the data objective function and a model objective function related to changes in the model in successive iterations. In an alternate embodiment of the invention, the formation azimuth angle is excluded from the iterative process by using derived relations between the multicomponent measurements.

公开(公告)号：US06553314B2

公开(公告)日：2003-04-22

申请号：US10244960

申请日：2002-09-17

申请人： Berthold F. Kriegshauser ,  Otto N. Fanini ,  Pravin Gupta ,  Liming Yu

发明人： Berthold F. Kriegshauser ,  Otto N. Fanini ,  Pravin Gupta ,  Liming Yu

IPC分类号： G01V338

CPC分类号： G01V3/28

摘要： Shoulder corrections are applied to measurements obtained from a multi-component electromagnetic logging tool. An anisotropic resistivity model is obtained using the shoulder corrected data. The process is iterated until a good match is obtained between the shoulder corrected data and the model output.

公开(公告)号：US5652333A

公开(公告)日：1997-07-29

申请号：US709047

申请日：1996-09-06

申请人： Michael S. C. Fung ,  Bill N. C. Sun ,  Cecily R. Y. Sun ,  Young Woo Kim ,  Liming Yu

发明人： Michael S. C. Fung ,  Bill N. C. Sun ,  Cecily R. Y. Sun ,  Young Woo Kim ,  Liming Yu

IPC分类号： C12N15/02 ,  A61K38/00 ,  C07K14/16 ,  C07K14/46 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C07K7/08 ,  A61K38/10

CPC分类号： C07K14/005 ,  C07K14/463 ,  C07K14/705 ,  C07K16/28 ,  A61K38/00 ,  C12N2740/16122 ,  Y10S530/81 ,  Y10S530/812

摘要： Disclosed are immunogens and peptides based on the binding site of gC1q-R for HIV-1 gp120 and immunogens and peptides based on the binding site of HIV-1 gp120 for gC1q-R. The sequence of the gC1q-R binding site for gp120 is shown in SEQ ID NO.: 2. The sequence of the HIV-1 gp120 binding site for gC1q-R is shown in SEQ ID NO.: 3. Also disclosed are antibodies and binding molecules to all such immunogens and peptides, and inducing the endogenous production of such antibodies.

摘要翻译： 公开了基于用于HIV-1 gp120的gC1q-R和免疫原的结合位点的免疫原和肽，以及基于HIV-1 gp120对于gC1q-R的结合位点的肽。 gp120的gC1q-R结合位点的序列如SEQ ID NO：2所示.GC1q-R的HIV-1 gp120结合位点的序列示于SEQ ID NO：3中。还公开了抗体和 结合分子到所有这样的免疫原和肽，并诱导这种抗体的内源性产生。

公开(公告)号：US08961787B2

公开(公告)日：2015-02-24

申请号：US12325672

申请日：2008-12-01

申请人： Nichole Lea Wood ,  Reginald Donovan Smith ,  Hongyi Zhou ,  Liming Yu ,  Brian Polizzotti ,  Peter Miller

发明人： Nichole Lea Wood ,  Reginald Donovan Smith ,  Hongyi Zhou ,  Liming Yu ,  Brian Polizzotti ,  Peter Miller

IPC分类号： C02F9/00 ,  B01D63/02 ,  A61M1/02 ,  B01D61/28 ,  B01D61/30

CPC分类号： G01N33/491 ,  A61M1/029 ,  B01D61/28 ,  B01D61/30 ,  B01D63/02 ,  B01D2313/18 ,  B01D2313/50 ,  C12N5/0647 ,  C12N5/0665 ,  G01N1/4077 ,  G01N2001/4083 ,  G01N2001/4088

摘要： Method and systems, for processing biological material, that contain a biological material in a vessel; add an aggregating agent to the material in the vessel and allow the material to separate into two or more distinct submaterials; extract one or more of the submaterials from the vessel; automatically transport one or more of the submaterials remaining in the vessel to a filtration device; and collect a resulting target retentate into a target retentate receptacle.

摘要翻译： 用于处理在容器中含有生物材料的生物材料的方法和系统; 向容器中的材料添加聚集剂，并使材料分离成两个或更多不同的子材料; 从容器中提取一种或多种副材料; 将剩余在容器中的一种或多种副材料自动输送到过滤装置; 并将得到的目标滞留物收集到目标滞留容器中。

公开(公告)号：US08778278B2

公开(公告)日：2014-07-15

申请号：US12503581

申请日：2009-07-15

申请人： Mingna Xiong ,  Bing Zhang ,  Liping Zheng ,  Hui Lei ,  Su Lu ,  Liming Yu ,  Lin Chen ,  Wenqing Peng ,  Yanrong Zhu

发明人： Mingna Xiong ,  Bing Zhang ,  Liping Zheng ,  Hui Lei ,  Su Lu ,  Liming Yu ,  Lin Chen ,  Wenqing Peng ,  Yanrong Zhu

IPC分类号： B01L3/00

CPC分类号： G01N33/54393 ,  B01L3/50 ,  C08G77/26 ,  C08G77/28 ,  C08G77/60 ,  C08L83/04 ,  C08L83/08 ,  C09D5/1675 ,  Y10T428/31612 ,  Y10T428/31663

摘要： The invention is a device comprising a substrate and a material provided on at least a portion of the substrate and having an exposed surface. The exposed surface of the material is non bio-adhesive. The invention further includes a non bio-adhesive material composition and a method of making a device having the same non bio-adhesive surface. The invention further provides a device having a coating of a hydrophobic material. In particular, the hydrophobic material coated portion of the device is resistant to bio-adhesion.

摘要翻译： 本发明是一种器件，其包括衬底和设置在衬底的至少一部分上并具有暴露表面的材料。 材料的暴露表面是非生物粘合剂。 本发明还包括非生物粘合剂材料组合物和制造具有相同非生物粘合剂表面的装置的方法。 本发明还提供了具有疏水性材料的涂层的装置。 特别地，该装置的疏水材料涂覆部分具有抗生物粘附性。

公开(公告)号：US08691939B2

公开(公告)日：2014-04-08

申请号：US11811425

申请日：2007-06-08

申请人： Liming Yu ,  Anup Sood ,  Mark Felipe Baptista

发明人： Liming Yu ,  Anup Sood ,  Mark Felipe Baptista

IPC分类号： A61K38/00

CPC分类号： C07K14/472 ,  C12Q1/37 ,  G01N2333/96441

摘要： The present invention provides a fluorogenic composition for assaying complement activation that comprises a substrate for C3 convertase that is linked to a first fluorophore and a second fluorophore, wherein the fluorescence of the first and second fluorophores are mutually substantially quenched when the two fluorophores are present at a distance less than the characteristic distance for the two fluorophores. In one embodiment, the fluorescence of the first fluorophore is substantially quenched by the second fluorophore, and the second fluorophore emits heat upon quenching. The present invention also provides a method for assaying complement activation, wherein the method includes the steps of incubating a biological sample with a polymer to provide a polymeric biological sample, followed by incubating the polymeric biological sample with the fluorogenic composition, and measuring the fluorescence. The method may optionally include the step of measuring the optical properties of the biological sample prior to the incubation steps. The present invention further provides a kit for assaying complement activation that comprises the fluorogenic composition disclosed herein.

摘要翻译： 本发明提供了用于测定补体活化的荧光组合物，其包含与第一荧光团和第二荧光团连接的C3转化酶底物，其中当两个荧光团存在于第一荧光团和第二荧光团时，第一和第二荧光团的荧光相互基本上骤冷 距离小于两个荧光团的特征距离。 在一个实施方案中，第一荧光团的荧光基本上被第二荧光团猝灭，第二荧光团在淬火时发出热。 本发明还提供了用于测定补体活化的方法，其中该方法包括以下步骤：用聚合物孵育生物样品以提供聚合生物样品，随后将聚合物生物样品与荧光组合物一起温育，并测量荧光。 该方法可以可选地包括在孵育步骤之前测量生物样品的光学性质的步骤。 本发明还提供了用于测定补体活化的试剂盒，其包含本文公开的荧光组合物。

公开(公告)号：US07959808B2

公开(公告)日：2011-06-14

申请号：US12262643

申请日：2008-10-31

申请人： Gary William Yeager ,  Liming Yu ,  Daniel Steiger ,  Yanshi Zhang

发明人： Gary William Yeager ,  Liming Yu ,  Daniel Steiger ,  Yanshi Zhang

IPC分类号： B01D61/00 ,  B01D39/00 ,  B01D53/22

CPC分类号： B01D71/68 ,  B01D2323/02 ,  B01D2325/36 ,  C08L39/08 ,  C08L81/06 ,  C08L2666/04

摘要： The present invention relates to methods and apparatuses for water filtration comprising contacting a water stream with a membrane comprising a polysulfone having structural units of Formula I wherein X is OH, NR1R2, or OR3; R1 and R2 are independently at each occurrence hydrogen, a C1-C5000 aliphatic radical, a C3-C12 cycloaliphatic radical, a C3-C12 aromatic radical, a polypeptide, a combination thereof, or R1 and R2 taken together form a 5- or 6-membered aliphatic ring or a 5-membered aromatic ring; R3 is a C1-C20 aliphatic radical, C3-C12 cycloaliphatic radical, C3-C12 aromatic radical, or a combination thereof; B′ and C′ are independently at each occurrence a nitro group, C1-C20 aliphatic radical, C3-C12 cycloaliphatic radical, C3-C12 aromatic radical, or a combination thereof; and q and r are independently at each occurrence 0 to 4. The present invention also relates to a method and apparatus for gas separation, the method comprising contacting a gas stream with a membrane comprising a polysulfone having structural units of Formula I.

摘要翻译： 本发明涉及水过滤的方法和装置，包括使水流与包含具有式I结构单元的聚砜的膜接触，其中X是OH，NR1R2或OR3; R1和R2各自独立地为氢，C1-C5000脂族基团，C3-C12脂环族基团，C3-C12芳族基团，多肽，其组合，或者R 1和R 2一起形成5-或6 脂族环或5元芳环; R3是C1-C20脂族基团，C3-C12脂环族基团，C3-C12芳族基团或其组合; B'和C'在每次出现时独立地为硝基，C 1 -C 20脂族基，C 3 -C 12脂环族基，C 3 -C 12芳族基或其组合; 并且q和r在每次出现时独立地为0至4.本发明还涉及一种用于气体分离的方法和装置，所述方法包括使气流与包含具有式I结构单元的聚砜的膜接触。

公开(公告)号：US07790410B2

公开(公告)日：2010-09-07

申请号：US12110104

申请日：2008-04-25

申请人： Liming Yu ,  Aaron Dulgar-Tulloch

发明人： Liming Yu ,  Aaron Dulgar-Tulloch

IPC分类号： C12Q1/56

CPC分类号： G01N33/86

摘要： Provided herein are techniques for screening materials for hemocompatibility. Hemocompatible materials may be advantageous when incorporated into devices that may come into direct contact with blood or other bodily fluids. Such techniques take advantage of conformational changes in fibrinogen when adsorbed onto certain materials. As a result of conformational changes, the fibrinogen has altered responsiveness to cleavage by thrombin. Accordingly, the products of thrombin cleavage of fibrinogen may be assessed to determine the hemocompatibility of a material.

摘要翻译： 本文提供了用于筛选血液相容性的材料的技术。 当结合到可能与血液或其他体液直接接触的装置中时，血液相容性材料可能是有利的。 当吸附到某些材料上时，这种技术利用纤维蛋白原的构象变化。 作为构象变化的结果，纤维蛋白原已经改变了对凝血酶切割的反应性。 因此，可以评估纤维蛋白原凝血酶切割的产物以确定材料的血液相容性。

公开(公告)号：US07737697B2

公开(公告)日：2010-06-15

申请号：US12014586

申请日：2008-01-15

申请人： Liming Yu ,  Berthold Kriegshäuser

发明人： Liming Yu ,  Berthold Kriegshäuser

IPC分类号： G01V3/10

CPC分类号： G01V3/28

摘要： Multi-component induction measurements are made using a resistivity logging tool in an anistropic earth formation. A subset of the multi-component measurements are inverted to first determine horizontal resistivities. Using the determined horizontal resistivities and another subset of the multi-component measurements, the vertical resistivities are obtained. Results of using the in-phase signals are comparable to those obtained using multifrequency focusing of quadrature signals.

摘要翻译： 多分量感应测量使用电磁测井工具在无水土层中进行。 多组分测量的子集被反转以首先确定水平电阻率。 使用确定的水平电阻率和多分量测量的另一子集，获得垂直电阻率。 使用同相信号的结果与使用正交信号的多频聚焦获得的结果相当。

公开(公告)号：US07612883B2

公开(公告)日：2009-11-03

申请号：US11749950

申请日：2007-05-17

申请人： Long Que ,  Jeffrey Bernard Fortin ,  Christopher Fred Keimel ,  Liming Yu ,  Zhiyong Wang

发明人： Long Que ,  Jeffrey Bernard Fortin ,  Christopher Fred Keimel ,  Liming Yu ,  Zhiyong Wang

IPC分类号： G01N21/25

CPC分类号： G01N21/648 ,  B01L3/5025 ,  B01L3/502761 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819

摘要： Disclosed herein is a plasmonics platform comprising a substrate; a plurality of periodically spaced nanoholes and/or nanoparticles disposed upon the substrate; wherein the average first order of periodicity between the nanoholes and/or the nanoparticles is about 5 to about 1,000 nm; and a microelectromechanical and/or a nanoelectromechanical system in operative communication with the substrate so as to vary the average first order of periodicity between the nanoholes and/or the nanoparticles.

摘要翻译： 本文公开了一种等离子体激元平台，其包括基底; 多个周期性间隔开的纳米孔和/或纳米颗粒设置在基底上; 其中所述纳米孔和/或纳米颗粒之间的平均一级周期为约5至约1000nm; 以及与所述基板操作性连通的微机电和/或纳米机电系统，以便改变所述纳孔与/或纳米颗粒之间的周期的平均一级。