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![Triazabenzo[E]Azulene Derivatives for the Treatment Of Tumors](/abs-image/US/2010/03/11/US20100063028A1/abs.jpg.150x150.jpg)
11.发明申请公开(公告)号：US20100063028A1
公开(公告)日：2010-03-11
申请号：US12513276
申请日：2007-09-29
IPC分类号： A61K31/55 , C07D487/02 , A61P35/00 , A61P25/28 , A61P9/00
CPC分类号： C07D487/04
摘要： Novel triazabenzo[e]azulene derivatives of the formula, (I) in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of TGF-beta receptor kinase and can be employed, inter alia, for the treatment of tumours.
摘要翻译： 式（I）的新型三氮杂苯并[e]薁衍生物，其中R 1，R 2和R 3具有权利要求1所示的含义，是TGF-β受体激酶的抑制剂，可用于治疗肿瘤 。
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公开(公告)号：US20080207699A1
公开(公告)日：2008-08-28
申请号：US11909134
申请日：2006-03-08
IPC分类号： A61K31/4439 , C07D401/12 , A61P35/00 , A61P27/02 , A61P37/00 , A61P29/00 , C07D401/14
CPC分类号： C07D401/12 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Compounds of the formula (I), in which R1 and R2 have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases, and can be employed, inter alia, for the treatment of tumours.
摘要翻译： 其中R 1和R 2 2具有权利要求1所示含义的式（I）化合物是酪氨酸激酶，特别是TIE-2和 Raf激酶，并且可以用于治疗肿瘤。
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13.发明申请Phenylurea Derivatives As Inhibitors Of Tyrosine Kinases For The Treatment Of Tumour Diseases 失效苯脲衍生物作为酪氨酸激酶抑制剂治疗肿瘤疾病公开(公告)号：US20080207682A1
公开(公告)日：2008-08-28
申请号：US11665183
申请日：2005-09-16
IPC分类号： A61K31/437 , C07D471/04 , A61P35/04
CPC分类号： C07D471/04
摘要： Compounds of the formula (I), in which R1a-R1e, R2a, R2b, R3 and X have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
摘要翻译： 式（I）的化合物，其中R 1a，R 1b，R 2b，R 2b，R 2b， R 3和X具有权利要求1中所示的含义，是酪氨酸激酶，特别是TIE-2和Raf激酶的抑制剂，特别可用于治疗肿瘤。
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公开(公告)号：US20070244135A1
公开(公告)日：2007-10-18
申请号：US11578375
申请日：2005-03-17
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of the formula (I), in which R6, R7, R8, R9 and X have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
摘要翻译： 式（I）的化合物，其中R 6，R 7，R 8，R 9和/或 X具有权利要求1中所示的含义，是酪氨酸激酶，特别是TIE-2和Raf激酶的抑制剂，特别可用于治疗肿瘤。
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公开(公告)号：US20070225347A1
公开(公告)日：2007-09-27
申请号：US10593295
申请日：2005-03-15
申请人： Guenter Hoelzemann , Helene Crassier , Alfred Jonczyk , Wolfgang Staehle , Arne Sutter , Wilfried Rautenberg , Francesc Mitjans , Elisabet Rosell-Vives , Jaume Adan , Marta Riera
发明人： Guenter Hoelzemann , Helene Crassier , Alfred Jonczyk , Wolfgang Staehle , Arne Sutter , Wilfried Rautenberg , Francesc Mitjans , Elisabet Rosell-Vives , Jaume Adan , Marta Riera
IPC分类号： C07D233/00 , C07D233/66
CPC分类号： C07D233/90
摘要： Compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, X and X′ have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
摘要翻译： 式（I）的化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9， R 10，R 11，X和X'具有权利要求1所示的含义，是酪氨酸激酶，特别是TIE-2和Raf激酶的抑制剂，可以是 尤其用于治疗肿瘤。
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16.发明申请PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS 失效对5-羟色胺和丝氨酸蛋白酶抑制剂作为抗病毒剂和抗坏血酸具有抑制作用的吡啶基 - 氨基亚氨基-I-间接衍生物公开(公告)号：US20060063811A1
公开(公告)日：2006-03-23
申请号：US10535916
申请日：2003-10-30
申请人： Guenter Hoelzemann , Kai Schiemann , Timo Heinrich , Henning Boettcher , Joachim Leibrock , Christoph Van Amsterdam , Gerd Bartoszyk
发明人： Guenter Hoelzemann , Kai Schiemann , Timo Heinrich , Henning Boettcher , Joachim Leibrock , Christoph Van Amsterdam , Gerd Bartoszyk
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/12
摘要： Novel indole derivatives of the formula (I), in which X, Y, R1, R1′, m and n have the meanings indicated in Patent Claim 1, have a strong affinity to the 5-HT1A and in some cases to the 5-HT1D receptors. The compounds inhibit serotonin reuptake, exhibit serotonin-agonistic and -antagonistic properties and are suitable as antidepressants, anxiolytics and for the treatment of neurodegenerative diseases
摘要翻译： 式（I）的新型吲哚衍生物，其中X，Y，R 1，R 1'，m和n具有专利权利要求1中所示的含义，具有 对5-HT 1A受体具有强亲和力，在某些情况下与5-HT 1D 1受体具有强亲和力。 这些化合物抑制5-羟色胺再摄取，显示5-羟色胺 - 激动和拮抗性，并且适合作为抗抑郁药，抗焦虑药和用于治疗神经变性疾病
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公开(公告)号：US20140142097A1
公开(公告)日：2014-05-22
申请号：US14118845
申请日：2012-04-11
IPC分类号： C07D401/12 , A61K31/4545 , A61K31/5377 , C07D401/14 , A61K31/496 , A61K45/06 , A61K31/497 , A61K31/444 , A61K31/501 , C07D491/048 , C07D471/04 , C07D409/14 , C07D405/14
CPC分类号： C07D401/12 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D471/04 , C07D491/048
摘要： Compounds of the formula (I) in which R, R1 and X have the meanings indicated in claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases
摘要翻译： 其中R，R 1和X具有权利要求1所示含义的式（I）化合物是TBK1和IKK的抑制剂; 并且可以用于治疗癌症和炎性疾病
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18.发明申请ALKOXY-THIENOPYRIMIDINES AS TGF-BETA RECEPTOR KINASE MODULATORS 审中-公开作为TGF-β受体激酶调节剂的ALKOXY-THIENOPYRIMININES公开(公告)号：US20120101095A1
公开(公告)日：2012-04-26
申请号：US13379773
申请日：2010-05-27
IPC分类号： A61K31/5377 , A61K31/519 , A61P35/00 , A61P35/04 , A61P9/00 , A61P25/28 , A61P9/10 , C12N9/99 , A61P43/00 , C07D495/04 , A61P31/18
CPC分类号： C07D495/04
摘要： Novel alkoxy-thienopyrimidine derivatives of formula (I) wherein R1 and R2 have the meaning according to claim 1, are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 式（I）的新型烷氧基 - 噻吩并嘧啶衍生物，其中R 1和R 2具有权利要求1的含义，是TGF-β受体I激酶的抑制剂，并且可以用于治疗肿瘤。
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![Triazabenzo[E]azulene derivatives for the treatment of tumors](/abs-image/US/2011/11/22/US08063040B2/abs.jpg.150x150.jpg)
公开(公告)号：US08063040B2
公开(公告)日：2011-11-22
申请号：US12513276
申请日：2007-09-29
IPC分类号： A01N43/00 , A61K31/55 , C07D487/00
CPC分类号： C07D487/04
摘要： Novel triazabenzo[e]azulene derivatives of the formula, (I) in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of TGF-beta receptor kinase and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 式（I）的新型三氮杂苯并[e]薁衍生物，其中R 1，R 2和R 3具有权利要求1所示的含义，是TGF-β受体激酶的抑制剂，可用于治疗肿瘤 。
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公开(公告)号：US08003657B2
公开(公告)日：2011-08-23
申请号：US11577270
申请日：2005-10-06
申请人： Frank Stieber , Alfred Jonczyk , Guenter Hoelzemann , Hans-Peter Buchstaller , Lars Thore Burgdorf , Wilfried Rautenberg , Hartmut Greiner
发明人： Frank Stieber , Alfred Jonczyk , Guenter Hoelzemann , Hans-Peter Buchstaller , Lars Thore Burgdorf , Wilfried Rautenberg , Hartmut Greiner
IPC分类号： A61K31/44 , C07D401/12
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10
摘要： The present invention relates to heterocyclic substituted bisarylurea derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式I的杂环取代的双芳基脲衍生物，式I化合物作为一种或多种激酶抑制剂的用途，式I化合物在制备药物组合物中的用途及其治疗方法， 包括向患者施用所述药物组合物。
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