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公开(公告)号：US20200283382A1
公开(公告)日：2020-09-10
申请号：US16637737
申请日：2018-08-09
IPC分类号： C07C323/65 , C07D335/04 , C07C323/22 , C07C49/757 , C07C62/38
摘要： The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs.
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公开(公告)号：US20200247852A1
公开(公告)日：2020-08-06
申请号：US16649905
申请日：2018-10-04
发明人： Baozhong Wang , Lei Deng
IPC分类号： C07K14/005 , C12N7/00 , A61K39/145 , A61K9/51
摘要： Disclosed are universal influenza based on a truncated influenza hemagglutin (HA) protein lacking a head domain (hrHA). Also disclosed is a composition comprising a nanoparticle coated with a disclosed hrHA polypeptide. Also disclosed is a composition comprising a virus like particle (VLP) expressing on its surface a disclosed hrHA polypeptide.
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13.发明申请公开(公告)号：US20190322643A1
公开(公告)日：2019-10-24
申请号：US16314535
申请日：2017-06-29
IPC分类号： C07D401/12 , C07D401/14 , C07D403/04 , A61P35/00
摘要： Inhibitors of HDAC and G9a inhibitors such as, for example, single compounds that inhibitor both HDAC and methyltransferase G9a (referred to herein as dual HDAC-G9a inhibitors, dual HDAC-G9a compounds, and dual HDAC-G9a inhibitor compounds) are described herein. For example, dual inhibitor compounds of Formulae I-III and methods of making and using thereof, are described herein. The dual inhibition activity of these compounds can provide inhibition of both histone deacetylase (HDAC) and histone methyltransferase G9a thereby providing anti-cancer effects.
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公开(公告)号：US20190134185A1
公开(公告)日：2019-05-09
申请号：US15841556
申请日：2017-12-14
发明人： Sang-Moo Kang , Min-Chul Kim
IPC分类号： A61K39/145 , C07K14/005 , A61K39/12 , C12N7/00
摘要： Disclosed are universal influenza A vaccines capable of providing broader cross-protection. The vaccine contains a fusion protein comprising tandem repeats of heterologous M2e epitope sequences that have been molecularly and genetically designed to provide broad cross-protection. The fusion protein may be incorporated into virus-like particles (VLPs) or a replicating live attenuated influenza virus vaccine, and administered alone or in combination with other influenza vaccines.
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公开(公告)号：US10235223B2
公开(公告)日：2019-03-19
申请号：US15312211
申请日：2015-05-20
发明人： Sushil K. Prasad , Sara Karamati , Dinesh Agarwal
摘要： Disclosed are various embodiments for a high-performance computing framework for cloud computing environments. A parallel computing application executable by at least one computing device of the cloud computing environment can call a message passing interface (MPI) to cause a first one of a plurality of virtual machines (VMs) of a cloud computing environment to store a message in a queue storage of the cloud computing environment, wherein a second one of the plurality of virtual machines (VMs) is configured to poll the queue storage of the cloud computing environment to access the message and perform a processing of data associated with the message. The parallel computing application can call the message passing interface (MPI) to access a result of the processing of the data from the queue storage, the result of the processing being placed in the queue storage by the second one of the plurality of virtual machines (VMs).
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公开(公告)号：US20180346863A1
公开(公告)日：2018-12-06
申请号：US15780487
申请日：2016-12-01
发明人： Bryan Stubblefield , Eric Gilbert
CPC分类号： B01F13/089 , C12M27/02
摘要： According to various implementations, the bioreactor system includes a bioreactor vessel, an impeller for stirring contents within the vessel, a temperature control source for controlling the temperature of the contents of the vessel, an aeration system for supplying air to the vessel, and one or more data loggers. According to certain implementations, the impeller is a novel impeller design that spins more smoothly and rapidly than known impellers. In addition, the bioreactor system is modular, durable, and relatively inexpensive compared to existing bioreactor systems, which allows for bench-scale implementation, use with differently sized bioreactor vessels, and accessibility to more educational programs, according to some implementations.
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公开(公告)号：US10095556B2
公开(公告)日：2018-10-09
申请号：US14653569
申请日：2013-12-19
发明人： Sushil K. Prasad , Xi He , Dinesh Agarwal
摘要： Disclosed are various embodiments for a parallel priority queue implemented on one or more many-core processors and/or multi-core processors such as those in general-purpose graphics processing units (GPGPUs). According to various embodiments, a priority may be determined according to a timestamp of an item, such as an event or an entry, in a priority queue. A priority queue interface may comprise functions to insert and remove entries from the priority queue. Priority order of the entries may be maintained as the entries are inserted and removed from the queue.
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公开(公告)号：US09993005B2
公开(公告)日：2018-06-12
申请号：US14773811
申请日：2014-03-12
发明人： George E. Pierce
摘要： Provided are methods and compositions for preventing or delaying a chill injury response of a plant or plant part that exhibits a chill injury response. The methods comprise exposing the plant or plant part to one or more bacteria, one or more enzymes, and/or an enzymatic extract isolated from one or more bacteria. The one or more bacteria, one or more enzymes, and/or the enzymatic extract isolated from one or more bacteria are exposed to the plant or plant part in a quantity sufficient to prevent or delay the chill injury response of the plant or plant part.
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公开(公告)号：US20180042904A1
公开(公告)日：2018-02-15
申请号：US15559728
申请日：2016-03-21
发明人： Jian-Dong LI
IPC分类号： A61K31/44 , A61K31/573 , A61K31/12 , C12N9/16 , A61K9/70 , A61K9/00 , A61K35/74 , A61K31/423 , A61K31/7088
CPC分类号： A61K31/44 , A61K9/0053 , A61K9/0073 , A61K9/7023 , A61K31/12 , A61K31/423 , A61K31/573 , A61K31/7088 , A61K35/74 , A61K45/06 , A61P11/00 , C12N9/16 , C12Y301/04053 , A61K2300/00
摘要： The present invention features, inter alia, pharmaceutical compositions and their use in the preparation of a medicament (e.g., a medicament for inflammation, such as an inflammatory lung disease) or in a therapeutic regimen. The compositions can include at least two active agents: a first agent that inhibits PDE4 (e.g., roflumilast) and a second active agent that inhibits the expression or activity of one or more PDE4B variants (e.g., PDE4B2). The compositions and methods will attenuate an unwanted up-regulation of a PDE4B (e.g., PDE4B2) and may thereby improve treatment with the first agent (e.g., roflumilast). For example, the second agent may improve the efficacy of the first agent, decrease the effective dose of the first agent, ameliorate the tolerance to the first agent that would otherwise develop (e.g., in patients with COPD exacerbation), reduce unwanted side effects caused by the first agent, or otherwise improve treatment regimes including a PDE4 inhibitor.
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公开(公告)号：US09717695B2
公开(公告)日：2017-08-01
申请号：US14401957
申请日：2013-05-18
发明人： Didier Merlin , Bo Xiao , Hamed Laroui
IPC分类号： A61K9/00 , A61K9/50 , A61K47/48 , C12N15/11 , A61B5/00 , A61K31/713 , A61K39/395 , A61K49/00 , C12N15/113 , C12N15/88
CPC分类号： A61K9/5036 , A61B5/0071 , A61B5/4255 , A61K31/713 , A61K39/3955 , A61K47/593 , A61K47/60 , A61K47/6835 , A61K47/6937 , A61K49/00 , C12N15/111 , C12N15/1136 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： The present invention features, inter alia, constructs for the delivery of therapeutic and diagnostic agents to a patient. The constructs can include a nanoparticle, a targeting agent that specifically binds a targeted tissue or cell, a therapeutic moiety, and a hydrogel. The constructs can be used in the treatment and diagnosis of bowel diseases, including inflammatory bowel disease (IBD) and colon cancer. In one embodiment, the therapeutic agent is a nucleic acid that mediates RNA inhibition (RNAi), and the invention is directed to treatments for IBD that combine the positive aspects of such agents {e.g., siRNAs) with the safety of a biodegradable polymeric delivery system to facilitate specific targeting of colonic tissues and cells. As the constructs can be formulated for oral administration, they are well tolerated and offer advantages with regard to patient compliance.
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