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307 条记录 (耗时 0.018 秒)

    Chemically and/or biologically reactive compounds
    107.
    发明申请
    Chemically and/or biologically reactive compounds 审中-公开
    化学和/或生物反应性化合物

    公开(公告)号：US20060127348A1

    公开(公告)日：2006-06-15

    申请号：US10513174

    申请日：2003-05-02

    申请人： Henry Lomasney ,  Christina Lomasney ,  John Grawe

    发明人： Henry Lomasney ,  Christina Lomasney ,  John Grawe

    IPC分类号： A61K31/785 ,  A61K31/765

    CPC分类号： A62D3/30 ,  A01N25/34 ,  A61K31/765 ,  A61K31/785 ,  A61K47/52 ,  A62D5/00 ,  A62D2101/02 ,  Y02W10/37 ,  A01N25/08 ,  A01N43/50 ,  A01N59/00

    摘要： This disclosure provides novel compositions comprising an inorganic and organic compound, which provides a means for the indirect attachment of a reactive species, such as an organic reactive molecule, within a binder polymer matrix. Such compositions provide a hydrophilic nanoscale domain that is uniformly dispersed within the polymer matrix. The nanoscale domain comprises inorganic particles having a nanoscale dimension. Such compositions can enhance the performance potential of the re-active species within the polymer material. The polymer composite that results from the introduction of such reactive species into a polymer matrix provides a self-decontaminating feature. The reactive species include those that are capable of associating with a halogen to form a complex that is active in decontamination of chemical or biological agents.

    摘要翻译： 本公开提供了包含无机和有机化合物的新型组合物，其提供了将活性物质如有机反应性分子间接连接到粘合剂聚合物基质内的手段。 这样的组合物提供均匀分散在聚合物基质内的亲水性纳米尺度结构域。 纳米尺度领域包括具有纳米级尺寸的无机颗粒。 这样的组合物可以增强聚合物材料内的再活性物质的性能潜力。 由将这种反应性物质引入到聚合物基质中产生的聚合物复合物提供了自净化特征。 反应性物质包括能够与卤素缔合以形成活性化学或生物试剂去污的络合物。

    Chemical compounds containing a superoxide scavenger and an organic nitrate or nitrite moiety
    108.
    发明申请
    Chemical compounds containing a superoxide scavenger and an organic nitrate or nitrite moiety 审中-公开
    含有超氧化物清除剂和有机硝酸盐或亚硝酸盐部分的化合物

    公开(公告)号：US20050165094A1

    公开(公告)日：2005-07-28

    申请号：US09859463

    申请日：2001-05-18

    申请人： Zhi Zhang ,  Declan Naughton ,  Yoshihiko Sumi ,  Atsushi Imaizumi

    发明人： Zhi Zhang ,  Declan Naughton ,  Yoshihiko Sumi ,  Atsushi Imaizumi

    IPC分类号： A61K47/48 ,  A61P9/00 ,  A61K31/21 ,  C07C23/04

    CPC分类号： A61K47/52

    摘要： Compounds for use in the treatment of heart disease include a superoxide scavenger and an organic nitrate or nitrite moiety. The compounds can be represented by the formula (A)n(B)m, in which A is a superoxide scavenger, B is an organic nitrate or organic nitrite moiety, and n and m are values between 1 and 8. These compounds do not suffer from the problem of patient tolerance that is associated with the use of conventional agents such as organic nitrates.

    摘要翻译： 用于治疗心脏病的化合物包括超氧化物清除剂和有机硝酸盐或亚硝酸盐部分。 化合物可以由式（A）n（B）m表示，其中A是超氧化物清除剂，B是有机硝酸盐或有机亚硝酸盐部分，n和m是1和8之间的值。这些化合物不 患有与使用常规药剂如有机硝酸盐有关的患者耐受性的问题。

    Nirtic oxide donors based on metallic centres
    109.
    发明申请
    Nirtic oxide donors based on metallic centres 失效
    基于金属中心的氧化氮供体

    公开(公告)号：US20040029854A1

    公开(公告)日：2004-02-12

    申请号：US10399408

    申请日：2003-04-23

    发明人： Luigi Casella ,  Marina Ziche

    IPC分类号： A61K031/555 ,  C07F003/08 ,  C07F015/06

    CPC分类号： C07D213/53 ,  A61K47/52 ,  C07D213/70 ,  C07D295/30 ,  C07F1/005

    摘要： The invention relates to ligand complexes characterised by the presence of a piperazineNONOate residue with metal cations where the cations derive from a transition metal or zinc in a stable oxidation state. These complexes are nitric oxide donors and exert an endothelio-protective effect on the coronary district and stimulate re-endothelialization and angiogenesis processes. The invention comprises a preparation process and the therapeutic use of said compounds.

    摘要翻译： 本发明涉及配位体配合物，其特征在于存在具有金属阳离子的哌嗪壬酸酯残基，其中阳离子源自稳定氧化态的过渡金属或锌。 这些复合物是一氧化氮供体，并对冠状动脉区域发挥内皮保护作用，并刺激内皮再生和血管生成过程。 本发明包括所述化合物的制备方法和治疗用途。