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公开(公告)号：US20160319038A1
公开(公告)日：2016-11-03
申请号：US15214160
申请日：2016-07-19
Applicant: GENENTECH, INC.
Inventor： YONGMEI CHEN , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC classification number: C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US09266961B2
公开(公告)日：2016-02-23
申请号：US13918755
申请日：2013-06-14
Applicant: Genentech, Inc.
Inventor： Yan Wu , Cecilia Pui Chi Chiu , Daniel K. Kirchhofer , Andrew Peterson , Ganesh A. Kolumam , Monica Kong Beltran , Paul Moran , Wei Li , Xanthe M. Lam , Lin Luis , Ada Hui
IPC: C07K16/40 , A61K39/395 , A61K39/00
CPC classification number: C07K16/40 , A61K39/39591 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention provides anti-PCSK9 antibodies, formulations, dosing regimens, and methods of using the same.
Abstract translation: 本发明提供抗PCSK9抗体，制剂，给药方案及其使用方法。
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公开(公告)号：US09161977B2
公开(公告)日：2015-10-20
申请号：US13762252
申请日：2013-02-07
Applicant: GENENTECH, INC.
Inventor： Avi Ashkenazi , Jing Qing , Christian Wiesmann , Yan Wu
IPC: A61K39/00 , A61K39/395 , C07K16/28
CPC classification number: C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
Abstract translation: 本发明提供FGFR3抗体，以及组合物和使用这些抗体的方法。
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公开(公告)号：US09017951B2
公开(公告)日：2015-04-28
申请号：US13673565
申请日：2012-11-09
Applicant: Genentech, Inc.
Inventor： Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
IPC: G01N33/53 , G01N33/574 , A61K39/395 , A61K45/06 , C07K16/28 , A61K31/69 , A61K39/00
CPC classification number: A61K39/3955 , A61K31/69 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/283 , C07K2317/24 , C07K2317/92 , A61K2300/00
Abstract: A method of determining the presence of FcRH5 in a biological sample suspected of containing FcRH5 is provided comprising exposing the biological sample to an isolated monoclonal anti-FcRH5 antibody.
Abstract translation: 提供了一种确定怀疑含有FcRH5的生物样品中FcRH5存在的方法，包括将生物样品暴露于分离的单克隆抗FcRH5抗体。
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公开(公告)号：US08969528B2
公开(公告)日：2015-03-03
申请号：US13765625
申请日：2013-02-12
Applicant: Genentech, Inc.
Inventor： Daniel K. Kirchhofer , Yan Wu
CPC classification number: C07K16/22 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention provides methods and compositions for modulating hepatocyte growth factor activator function.
Abstract translation: 本发明提供调节肝细胞生长因子激活功能的方法和组合物。
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Patent Agency Ranking
公开(公告)号：US20140322129A1
公开(公告)日：2014-10-30
申请号：US14207878
申请日：2014-03-13
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K45/06 , A61K51/10 , A61K38/05 , A61K31/704 , A61K47/48 , G01N33/574
CPC classification number: C07K16/3015 , A61K31/5377 , A61K31/5517 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2827 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/567 , C07K2317/77 , C07K2317/92 , G01N33/57492 , A61K2300/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗B7-H4抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20140127197A1
公开(公告)日：2014-05-08
申请号：US13760751
申请日：2013-02-06
Applicant: GENENTECH, INC.
Inventor： Allen J. Ebens , Alane M. Gray , Wei-Ching Liang , Yan Wu , Shang-Fan Yu
IPC: C07K16/30 , A61K45/06 , A61K39/395
CPC classification number: C07K16/3061 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6855 , C07K16/2803 , C07K16/2896 , C07K2317/24 , C07K2317/56 , C07K2317/77 , C07K2317/92
Abstract: Anti-CD22 antibodies and immunoconjugates thereof are provided. Methods of using anti-CD22 antibodies and immunoconjugates thereof are provided.
Abstract translation: 提供抗CD22抗体及其免疫偶联物。 提供了使用抗CD22抗体及其免疫偶联物的方法。
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公开(公告)号：US20140037643A1
公开(公告)日：2014-02-06
申请号：US13773843
申请日：2013-02-22
Applicant: Genentech, Inc.
Inventor： Siebel W. Christian , Yan Wu
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The invention provides anti-Notch antibodies, and in particular, antibodies that bind Notch2 NRR, and methods of using the same.
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公开(公告)号：US08617559B2
公开(公告)日：2013-12-31
申请号：US13682581
申请日：2012-11-20
Applicant: Genentech, Inc.
Inventor： Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
IPC: A61K39/00
CPC classification number: G01N33/6854 , A61K31/138 , A61K31/4196 , A61K31/454 , A61K31/4745 , A61K31/517 , A61K31/56 , A61K31/568 , A61K31/5685 , A61K31/69 , A61K33/24 , A61K38/19 , A61K39/0011 , A61K39/39533 , A61K39/39558 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/283 , C07K2317/24 , C07K2317/522 , C07K2317/73 , G01N33/574 , G01N33/6857 , Y02A50/473
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20130287776A1
公开(公告)日：2013-10-31
申请号：US13762252
申请日：2013-02-07
Applicant: Genentech, Inc.
Inventor： Avi Ashkenazi , Jing Qing , Christian Wiesmann , Yan Wu
IPC: A61K39/395
CPC classification number: C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
Abstract translation: 本发明提供FGFR3抗体，以及组合物和使用这些抗体的方法。
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