公开(公告)号：US20180162912A1

公开(公告)日：2018-06-14

申请号：US15829651

申请日：2017-12-01

申请人： LONDON SCHOOL AND HYGIENE AND TROPICAL MEDICINE

发明人： Ursula Gompels ,  David Dewin ,  Julie Catusse

IPC分类号： C07K14/005 ,  C12N7/00 ,  A61K39/245 ,  C07K14/52 ,  A61K38/00 ,  A61K39/00

摘要： A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine receptors. Uses of the chemokine in treatment of a range of diseases, including cancers and HIV/AIDS, are described.

公开(公告)号：US20180153982A1

公开(公告)日：2018-06-07

申请号：US15676330

申请日：2017-08-14

申请人： Duke University

发明人： John H. Sampson ,  Duane A. Mitchell

IPC分类号： A61K39/245 ,  A61K39/12 ,  A61K39/39 ,  A61K45/06 ,  C07K14/005 ,  C12N7/00 ,  A61K31/7105 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K31/7105 ,  A61K39/12 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16122 ,  C12N2710/16134

摘要： The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.

公开(公告)号：US20180153976A1

公开(公告)日：2018-06-07

申请号：US15737679

申请日：2016-06-06

申请人： VAXIMM AG

发明人： Heinz Lubenau

IPC分类号： A61K39/00 ,  C12N1/36 ,  C07K14/005 ,  A61K39/245 ,  A61P31/22 ,  A61P35/00 ,  A61K45/06

CPC分类号： A61K39/0011 ,  A61K39/245 ,  A61K45/06 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/542 ,  A61K2039/585 ,  A61P31/22 ,  A61P35/00 ,  C07K14/005 ,  C12N1/36 ,  C12N2710/16122 ,  C12N2710/16134 ,  Y02A50/484

摘要： The present invention relates to an attenuated strain of Salmonella comprising a DNA molecule encoding CMV pp65. In particular, the present invention relates to the use of said attenuated strain of Salmonella in cancer immunotherapy.

公开(公告)号：US09950056B2

公开(公告)日：2018-04-24

申请号：US15024200

申请日：2014-09-19

申请人： Duke University

发明人： John H. Sampson ,  Duane A. Mitchell

IPC分类号： A61K39/245 ,  A61K39/12 ,  A61K35/17 ,  A61K38/16 ,  A61K39/39 ,  A61K45/06 ,  C12N5/0783 ,  C12N5/0784 ,  C12N7/00 ,  A61K38/00 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K35/17 ,  A61K38/00 ,  A61K38/164 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/55533 ,  A61K2039/55538 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/55594 ,  A61K2039/572 ,  A61K2039/6081 ,  C12N5/0636 ,  C12N5/0639 ,  C12N7/00 ,  C12N2710/16134 ,  C12N2710/16171

摘要： The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.

公开(公告)号：US09933427B2

公开(公告)日：2018-04-03

申请号：US15439495

申请日：2017-02-22

申请人： ENZO BIOCHEM, INC

发明人： Gerard Nuovo ,  Virginia Nivar

IPC分类号： G01N33/569 ,  C07K16/24 ,  C12Q1/70 ,  C12Q1/68 ,  C07K16/08 ,  A61K39/12 ,  A61K39/245 ,  C12N7/00 ,  C07K14/005

CPC分类号： G01N33/56994 ,  C07K16/085 ,  C07K16/244 ,  C07K2317/33 ,  C07K2317/76 ,  C12N2710/16021 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/705 ,  C12Q2600/158 ,  G01N2333/03 ,  G01N2800/7052

摘要： Provided are methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient. Further provided are methods of monitoring disease progression and/or the efficacy of therapy by measuring the levels of a virus-specific element in a sample from a patient, and methods of identifying therapeutic agents that show efficacy in reducing levels of virus-specific agents in vitro. Still further provided are methods of treating idiopathic pulmonary fibrosis, a lymphoproliferative disease and cancer, as well as to methods of preventing viral infection, including Herpesvirus saimiri infection.

公开(公告)号：US09931395B2

公开(公告)日：2018-04-03

申请号：US14606973

申请日：2015-01-27

申请人： CITY OF HOPE

发明人： Don J. Diamond ,  Felix Wussow

IPC分类号： A61K39/245 ,  C12N7/00 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/24143 ,  C12N2799/023 ,  C12N2800/204

摘要： In one embodiment, an expression system for expressing a UL128 complex is provided herein. The expression system may include a bacterial artificial chromosome (BAC) construct, wherein the BAC construct comprises a viral vector inserted with a set of DNA sequences that encode a UL128 complex. In another embodiment, a vaccine composition for preventing HCMV infection is provided. The vaccine composition may include a viral or bacterial vector capable of expressing a UL128 complex and a pharmaceutically acceptable carrier, adjuvant, additive or combination thereof or additional vector expressing a protein adjuvant. The viral vector may be an MVA and the UL128 complex includes five HCMV proteins or antigenic fragments thereof: UL128, UL130, UL131A, gL, and gH. In some embodiments, the viral vector is further inserted with one or more additional DNA sequences that encode one or more additional HCMVHCMV proteins or antigenic fragments thereof such as pp65, gB or both, or such as gM/gN or gO.

公开(公告)号：US20180008695A1

公开(公告)日：2018-01-11

申请号：US15713019

申请日：2017-09-22

申请人： BIOMEDICAL RESEARCH MODELS, INC.

发明人： Kejian YANG ,  Dennis L. GUBERSKI

IPC分类号： A61K39/12 ,  C07K14/035 ,  C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/245 ,  C07K16/08 ,  C07K14/03

CPC分类号： A61K39/12 ,  A61K38/00 ,  A61K39/245 ,  A61K2039/543 ,  A61K2039/55555 ,  C07K14/005 ,  C07K14/03 ,  C07K14/035 ,  C07K16/085 ,  C12N2710/16634

摘要： The invention provides methods and kits for inducing a therapeutic immunity in animals (e.g. mammals) against viral antigens, including herpes-simplex virus type 2. In particular, the invention provides a method of treating animals with an established HSV-2 infection by administering a therapeutic vaccine comprising a priming dose of a nucleic acid encoding an HSV-2 antigen, an initial or first boosting dose comprising the protein form of the antigen encapsulated in liposomes, and one or more subsequent boosting doses comprising both the nucleic acid encoding the HSV-2 antigen and the liposomal-encapsulated protein antigen.

公开(公告)号：US20170340730A1

公开(公告)日：2017-11-30

申请号：US15639296

申请日：2017-06-30

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

发明人： Hildegund C.J. ERTL ,  Marcio O. LASARO ,  Luis C.S. FERREIRA

IPC分类号： A61K39/245 ,  C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/10 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/16622 ,  C12N2710/16634 ,  Y02A50/412

摘要： Chimeric protein constructs including a herpesvirus glycoprotein D (gD) and a heterologous polypeptide that interact with herpes virus entry mediator (HVEM) and enhance and enhance an immune response against the heterologous polypeptide and methods for their use are provided.

公开(公告)号：US09801936B2

公开(公告)日：2017-10-31

申请号：US15213711

申请日：2016-07-19

申请人： Pulike Biological Engineering, Inc.

发明人： Kegong Tian ,  Feifei Tan ,  Jinzhong Sun ,  Xuke Zhang

IPC分类号： A61K39/00 ,  C12N7/00 ,  A61K39/245 ,  C12N7/08 ,  A61K39/12

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  C12N7/00 ,  C12N7/08 ,  C12N2710/16734 ,  C12N2710/16764

摘要： This invention provides a method of attenuating porcine pseudorabies virus, which can effectively and reproducibly attenuate porcine pseudorabies virus. The attenuated strain of porcine pseudorabies virus by use of said method can provide effective immunization for pigs.

公开(公告)号：US20170275339A1

公开(公告)日：2017-09-28

申请号：US15618740

申请日：2017-06-09

申请人： GenVec, Inc.

发明人： Lisa Wei ,  Douglas E. Brough ,  Christopher Lazarski

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N7/00 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/53 ,  A61K2039/545 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2799/022 ,  C12N2800/22

摘要： Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.