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    THERAPEUTIC VACCINES FOR TREATING HERPES SIMPLEX VIRUS TYPE-2 INFECTIONS
    5.
    发明申请
    THERAPEUTIC VACCINES FOR TREATING HERPES SIMPLEX VIRUS TYPE-2 INFECTIONS 有权
    用于治疗阴道病毒的简易病毒2型感染的治疗疫苗

    公开(公告)号：US20140193483A1

    公开(公告)日：2014-07-10

    申请号：US14149670

    申请日：2014-01-07

    Applicant: Biomedical Research Models, Inc.

    Inventor： Kejian YANG ,  Dennis L. Guberski

    IPC: A61K39/245

    CPC classification number: A61K39/12 ,  A61K38/00 ,  A61K39/245 ,  A61K2039/543 ,  A61K2039/55555 ,  C07K14/005 ,  C07K14/03 ,  C07K14/035 ,  C07K16/085 ,  C12N2710/16634

    Abstract: The invention provides methods and kits for inducing a therapeutic immunity in animals (e.g. mammals) against viral antigens, including herpes-simplex virus type 2. In particular, the invention provides a method of treating animals with an established HSV-2 infection by administering a therapeutic vaccine comprising a priming dose of a nucleic acid encoding an HSV-2 antigen, an initial or first boosting dose comprising the protein form of the antigen encapsulated in liposomes, and one or more subsequent boosting doses comprising both the nucleic acid encoding the HSV-2 antigen and the liposomal-encapsulated protein antigen.

    Abstract translation: 本发明提供用于在动物（例如哺乳动物）中诱导针对病毒抗原（包括单纯疱疹病毒2型）的治疗免疫的方法和试剂盒。特别地，本发明提供了一种通过施用已知的HSV-2感染来治疗动物的方法 包含起始剂量的编码HSV-2抗原的核酸的治疗性疫苗，包含在脂质体中的抗原蛋白形式的初始或第一加强剂量，以及一个或多个随后的加强剂量，其包含编码HSV- 2抗原和脂质体包封的蛋白质抗原。

    Nucleotide-specific recognition sequences for designer TAL effectors
    6.
    发明授权
    Nucleotide-specific recognition sequences for designer TAL effectors 有权

    公开(公告)号：US08507272B2

    公开(公告)日：2013-08-13

    申请号：US13767986

    申请日：2013-02-15

    Applicant: The Broad Institute Inc.

    Inventor： Feng Zhang ,  Le Cong

    IPC: C12N15/85 ,  C12N15/00

    CPC classification number: C12N5/06 ,  C07K14/03 ,  C07K14/195 ,  C07K14/4703 ,  C07K2319/80 ,  C12N5/0686 ,  C12N9/1241 ,  C12N9/22 ,  C12N15/635 ,  C12Q1/6816 ,  C12Q2522/10

    Abstract: The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus.

    Nucleotide-Specific Recognition Sequences For Designer TAL Effectors
    9.
    发明申请
    Nucleotide-Specific Recognition Sequences For Designer TAL Effectors 有权
    设计师TAL效应物的核苷酸特异性识别序列

    公开(公告)号：US20130137160A1

    公开(公告)日：2013-05-30

    申请号：US13732266

    申请日：2012-12-31

    Applicant: The Broad Institute Inc. ,  Massachusetts Institute of Technology

    Inventor： Feng Zhang ,  Le Cong

    IPC: C07K14/195 ,  C07K14/03 ,  C12N9/22 ,  C07K14/47 ,  C12N9/12

    CPC classification number: C12N5/06 ,  C07K14/03 ,  C07K14/195 ,  C07K14/4703 ,  C07K2319/80 ,  C12N5/0686 ,  C12N9/1241 ,  C12N9/22 ,  C12N15/635 ,  C12Q1/6816 ,  C12Q2522/10

    Abstract: The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus.

    Abstract translation: 本发明涉及改变感兴趣的基因座的表达或特异性靶向动物细胞中的目的基因组的表达的方法，其可能涉及使基因组座位与包含脱氧核糖核酸（DNA）的非天然存在或工程化组合物接触 ）结合多肽，DNA结合结构域包含至少五个或更多个转录激活子样效应子（TALE）单体和至少一种或多种特异性命令靶向感兴趣的基因组座位的半单体，以及 C端封端区，其中所述多肽包括至少一个或多个效应域，并且其中所述多肽由密码子优化的核酸分子编码和翻译，使得所述多肽优先结合所述基因组座位的DNA。

    Nucleotide-specific recognition sequences for designer TAL effectors
    10.
    发明授权
    Nucleotide-specific recognition sequences for designer TAL effectors 有权
    设计师TAL效应器的核苷酸特异性识别序列

    公开(公告)号：US08450107B1

    公开(公告)日：2013-05-28

    申请号：US13604945

    申请日：2012-09-06

    Applicant: Feng Zhang ,  Le Cong

    Inventor： Feng Zhang ,  Le Cong

    IPC: C12N15/85 ,  C12N15/00

    CPC classification number: C12N5/06 ,  C07K14/03 ,  C07K14/195 ,  C07K14/4703 ,  C07K2319/80 ,  C12N5/0686 ,  C12N9/1241 ,  C12N9/22 ,  C12N15/635 ,  C12Q1/6816 ,  C12Q2522/10

    Abstract: The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus.

    Abstract translation: 本发明涉及改变感兴趣的基因座的表达或特异性靶向动物细胞中的目的基因组的表达的方法，其可能涉及使基因组座位与包含脱氧核糖核酸（DNA）的非天然存在或工程化组合物接触 ）结合多肽，DNA结合结构域包含至少五个或更多个转录激活子样效应子（TALE）单体和至少一种或多种特异性命令靶向感兴趣的基因组座位的半单体，以及 C端封端区，其中所述多肽包括至少一个或多个效应域，并且其中所述多肽由密码子优化的核酸分子编码和翻译，使得所述多肽优先结合所述基因组座位的DNA。

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