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公开(公告)号：US20200230183A1
公开(公告)日：2020-07-23
申请号：US16825225
申请日：2020-03-20
申请人： Osei, Inc.
发明人： Thomas P. Parks , Angela Marcobal
IPC分类号： A61K35/747 , A61P31/04 , A61K45/06 , A61K47/10 , A61K47/22 , A61K47/18 , A61K9/00 , A61K47/26 , C12N1/04 , A61K9/19 , C12N1/20 , A61P15/02 , A61K47/02
摘要： This invention provides for a dry preserved formulation of Lactobacillus suitable for administration to people as a pro-biotic or live biotherapeutic treatment where the formulation is stable, has high potency, and contains no animal-derived excipients.
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公开(公告)号：US20200155465A9
公开(公告)日：2020-05-21
申请号：US15975733
申请日：2018-05-09
申请人： TherapeuticsMD, Inc.
IPC分类号： A61K9/48 , A61K31/565 , A61K9/00 , A61P15/02
摘要： Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).
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公开(公告)号：US20190388425A1
公开(公告)日：2019-12-26
申请号：US16479400
申请日：2018-01-19
发明人： Ulrich KLAR , Heike SCHÄCKE , Detlev SÜLZLE , Stephan MENZ
IPC分类号： A61K31/519 , A61K31/5386 , C07D519/00 , A61P35/00 , A61P15/02 , A61P29/00
摘要： The present invention relates to substituted imidazopyridinpyrimidine compounds of general formula (I) which inhibit MKNK1 and MKNK2 kinase (also known as MAP Kinase interacting Kinase, Mnk1 and Mnk2), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20190330256A1
公开(公告)日：2019-10-31
申请号：US16505501
申请日：2019-07-08
摘要： Antimicrobial compounds and compositions of Formula (I) and methods of use are disclosed.
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公开(公告)号：US20190330255A1
公开(公告)日：2019-10-31
申请号：US16505497
申请日：2019-07-08
摘要： Antimicrobial compounds and compositions of Formula (I) and methods of use are disclosed.
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公开(公告)号：US20190298760A1
公开(公告)日：2019-10-03
申请号：US16126218
申请日：2018-09-10
申请人： Reoxcyn, LLC
发明人： Kurt Richards , Jeffrey Mocny
摘要： Described herein are methods and formulations for treating, inhibiting, or ameliorating vaginitis, including bacterial vaginosis. Aspects described herein relate to formulations including a reactive oxygen species, a rheology agent, and a silicone polymer and methods of using these formulations for treating, ameliorating, or inhibiting a vaginitis, including bacterial vaginosis.
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公开(公告)号：US20190224150A1
公开(公告)日：2019-07-25
申请号：US16338977
申请日：2017-10-03
申请人： EVOFEM, INC.
发明人： David R. FRIEND
摘要： Described herein are methods of reducing the risk of recurrence of bacterial vaginosis by intravaginal administration of compositions comprising L-lactic acid, polymer thickener, and preservative.
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98.发明申请公开(公告)号：US20180117100A1
公开(公告)日：2018-05-03
申请号：US15566352
申请日：2016-03-24
申请人： KoBioLabs, Inc.
发明人： Gwang Pyo KO , Hyun Ju YOU , Bo Mi KWON
IPC分类号： A61K35/747 , C12R1/225 , A61P31/04 , A61P31/10 , A61P31/20 , A61P15/02 , A23L33/00 , A23L33/135 , A23L2/52 , A23C9/123
CPC分类号： A61K35/747 , A23C9/1234 , A23L2/52 , A23L33/135 , A23L33/40 , A23V2002/00 , A23Y2220/00 , A23Y2220/35 , A23Y2220/37 , A23Y2220/41 , A61P15/02 , A61P31/04 , A61P31/10 , A61P31/20 , C12R1/225
摘要： The present invention relates to a novel Lactobacillus sp. isolation strain having an activity to inhibit the growth of vaginitis pathogens, and a pharmaceutical composition, a health functional food, and a cleansing product, comprising the strain as an active ingredient. Therefore, the present invention exhibits an effect of inhibiting the growth of Sneathia spp. pathogens associated with the infection with human papillomavirus (HPV) and the incidence of bacterial vaginitis, Gardnerella vaginalis as a vaginitis pathogen, and Candida albicans as a causative bacteria of Candidal vaginitis, and an effect of recovering and maintaining the vaginal microflora, and thus can be used for the prevention and treatment of female vaginitis.
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公开(公告)号：US09675546B2
公开(公告)日：2017-06-13
申请号：US12163334
申请日：2008-06-27
IPC分类号： A61K9/02 , A61K31/215 , A61P15/02 , A61P5/24 , A61K31/57 , A61K9/00 , A61K31/56 , A61K47/02 , A61K47/14 , A61K47/22
CPC分类号： A61K9/0034 , A61K9/02 , A61K31/215 , A61K31/56 , A61K31/57 , A61K47/02 , A61K47/14 , A61K47/22 , A61K2300/00
摘要： The present invention provides novel pharmaceutical compositions containing triphenylethylene derivative compounds, and methods of using the composition for treatment of symptoms associated with atrophic vaginitis. The pharmaceutical compositions are prepared for the vaginal administration of triphenylethylene derivative compounds in single or combination therapies. Preferably, the triphenylethylene derivative is tamoxifen.
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公开(公告)号：US09044387B2
公开(公告)日：2015-06-02
申请号：US12742357
申请日：2008-11-19
申请人： Xiaobin Zhao , Kevin Alexander Burd
发明人： Xiaobin Zhao , Kevin Alexander Burd
IPC分类号： A61K31/722 , A61P15/02 , A61K9/00 , A61P15/08 , A61K31/728
CPC分类号： A61K9/0034 , A61K31/722 , A61K31/728
摘要： A vaginal lubricant comprising high molecular weight hyaluronic acid combined with low molecular weight hyaluronic acid and/or chitosan which has improved stability and which has applications in, for example, maintaining and/or promoting sperm motility.
摘要翻译： 包含高分子量透明质酸与低分子量透明质酸和/或壳聚糖结合的阴道润滑剂，其具有改善的稳定性并且可用于例如维持和/或促进精子活力。
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