公开(公告)号：US20100210582A1

公开(公告)日：2010-08-19

申请号：US12708283

申请日：2010-02-18

申请人： Kendal L. Stewart ,  Stephen J. Orlando

发明人： Kendal L. Stewart ,  Stephen J. Orlando

IPC分类号： A61K31/519 ,  A61K31/7056 ,  A61K31/675 ,  A61P3/02 ,  G01N33/68

CPC分类号： G01N33/6815 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/48 ,  A61K31/4375 ,  A61K31/4415 ,  G01N2800/28 ,  G01N2800/38 ,  A61K2300/00

摘要： A method for predicting the likelihood of developing ASD and ASD-related diseases in a subject is disclosed. The method includes the steps of measuring the level of homocysteine, a homocysteine precursor or a homocysteine metabolite in the subject and evaluating the likelihood of developing ASD and ASD-related diseases based on the result of measurement. A subject is deemed to have a high risk of developing ASD and ASD-related diseases if the level of homocysteine, the homocysteine precursor or the homocysteine metabolite in the subject is at or below a threshold level. Also disclosed are a composition for reducing the risk of developing ASD, ASD-related diseases and adult neurological abnormalities and a method for determining a vaccination schedule in a subject.

摘要翻译： 公开了一种预测受试者发生ASD和ASD相关疾病的可能性的方法。 该方法包括测量受试者中同型半胱氨酸，同型半胱氨酸前体或同型半胱氨酸代谢物的水平的步骤，并且基于测量结果评估发展ASD和ASD相关疾病的可能性。 如果受试者的同型半胱氨酸，同型半胱氨酸前体或同型半胱氨酸代谢物的水平处于或低于阈值水平，则被认为具有发展ASD和ASD相关疾病的高风险。 还公开了用于降低发展ASD，ASD相关疾病和成人神经系统异常的风险的组合物以及用于确定受试者的疫苗接种时间表的方法。

公开(公告)号：US20100129923A1

公开(公告)日：2010-05-27

申请号：US12596551

申请日：2008-05-02

申请人： Andrea DeBarber ,  Robert D. Steiner

发明人： Andrea DeBarber ,  Robert D. Steiner

IPC分类号： G01N33/53

CPC分类号： G01N33/92 ,  G01N33/6893 ,  G01N2800/38 ,  Y10T436/200833 ,  Y10T436/203332 ,  Y10T436/24

摘要： Embodiments of the present invention provide for detecting and/or screening for conditions associated with altered sterols by dehvatization of sterols to provide suitable sensitivity and selectivity of detection using tandem mass spectrometry with electrospray ionization. Such testing may be performed to detect and/or screen for conditions such as Smith-Lemli-Opitz syndrome, familial hypercholesterolemia, and cerebrotendinous xanthomatosis, or certain bile acid disorders.

摘要翻译： 本发明的实施方案提供了通过固醇的脱氢来检测和/或筛选与改变的甾醇相关的条件，以提供具有电喷雾电离的串联质谱法的合适的检测灵敏度和选择性。 可以进行这种测试以检测和/或筛选诸如史密斯 - 莱米 - 奥皮茨综合征，家族性高胆固醇血症和脑血管性黄瘤病或某些胆汁酸疾病的病症。

公开(公告)号：US20070166354A1

公开(公告)日：2007-07-19

申请号：US11646671

申请日：2006-12-28

申请人： Bridget Barrett-Reis

发明人： Bridget Barrett-Reis

IPC分类号： A61K47/00 ,  A61K31/12 ,  A61K31/015 ,  A61B5/00

CPC分类号： A23L2/66 ,  A23L33/10 ,  A23L33/115 ,  A23L33/17 ,  A23L33/40 ,  A23V2002/00 ,  G01N33/82 ,  G01N2800/38

摘要： Disclosed is a method of reducing the risk or severity of retinopathy of prematurity in preterm infants. The method comprises (a) measuring skin carotenoid levels in preterm infants, preferably by Raman Spectroscopy, and then (b) administering supplemental carotenoids to those infants in need thereof, wherein the supplemental carotenoids comprise lutein, lycopene, beta-carotene, and zeaxanthin. The supplemental carotenoids may be provided by an infant formula comprising, on a ready-to-feed basis, from about 100 to about 2000 mcg/liter of total carotenoids, wherein the total carotenoids include at least about 50 mcg/liter of lutein. The formulas may further comprise docosahexaenoic acid.

摘要翻译： 公开了一种降低早产儿早产儿视网膜病变风险或严重程度的方法。 该方法包括：（a）优选通过拉曼光谱法测定早产儿的皮肤类胡萝卜素水平，然后（b）向有需要的那些婴儿施用补充的类胡萝卜素，其中补充的类胡萝卜素包括叶黄素，番茄红素，β-胡萝卜素和玉米黄质。 补充的类胡萝卜素可以由婴儿配方提供，其包括在即食物基础上约100至约2000mcg /升的总类胡萝卜素，其中总类胡萝卜素包括至少约50mcg /升的叶黄素。 该配方还可以包含二十二碳六烯酸。

公开(公告)号：US20040265937A1

公开(公告)日：2004-12-30

申请号：US10487321

申请日：2004-02-17

发明人： Masahiko Katayama ,  Noriko Sanzen ,  Kiyotoshi Sekiguchi

IPC分类号： G01N033/53 ,  G01N033/537 ,  G01N033/543

CPC分类号： C07K16/18 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/7055 ,  G01N2800/38

摘要： A method of determining a laminin 5 antigen in a biological sample, comprising the steps of bringing an antibody reactive to a laminin 5 null2 chain N-terminal fragment into contact with the biological sample; measuring a reaction of the antibody; and determining an amount of the laminin 5 antigen based on a measurement result of the reaction, as well as, a method of detecting a laminin 5-producing tumor cell, a method of examining acute respiratory distress syndrome and a method of evaluating malignancy of a malignant tumor based on the assay method.

摘要翻译： 一种确定生物样品中层粘连蛋白5抗原的方法，包括以下步骤：使与层粘连蛋白5γ2链N末端片段反应的抗体与生物样品接触; 测量抗体的反应; 以及基于反应的测定结果确定层粘连蛋白5抗原的量，以及检测产生层粘连蛋白5的肿瘤细胞的方法，检查急性呼吸窘迫综合征的方法和评价恶性肿瘤的方法 基于检测方法的恶性肿瘤。

公开(公告)号：US20030211503A1

公开(公告)日：2003-11-13

申请号：US10262391

申请日：2002-10-01

发明人： David F. Carpentieri

IPC分类号： C12Q001/68 ,  G01N033/574

CPC分类号： G01N33/57407 ,  G01N33/57496 ,  G01N2800/38

摘要： The present invention is directed to methods wherein the cytolocalization of WT1 protein can be used as a tool in the differential diagnosis of soft tissue tumors. Specifically, the invention is directed to the novel finding that elevated levels of WT1 protein in the cytoplasm of cells derived from a soft tissue tumor sample provide a positive diagnostic indicator for rhabdomyosarcoma (RMS).

摘要翻译： 本发明涉及其中WT1蛋白的细胞定位可用作软组织肿瘤鉴别诊断中的工具的方法。 具体地说，本发明涉及一种新的发现，即来自软组织肿瘤样品的细胞的细胞质中WT1蛋白水平升高为横纹肌肉瘤（RMS）提供了积极的诊断指标。

公开(公告)号：US5716794A

公开(公告)日：1998-02-10

申请号：US626243

申请日：1996-03-29

申请人： Amin Tjota

发明人： Amin Tjota

IPC分类号： C07K14/47 ,  G01N33/68 ,  G01N33/53 ,  A23J1/00 ,  C07K1/00 ,  C07K16/00

CPC分类号： G01N33/6893 ,  C07K14/4715 ,  G01N2800/38

摘要： In this invention a novel antigen is provided for screening patients suspected of having celiac disease. The antigen is prepared by starting with human placenta tissue which is perfused with a herpes and collagenase buffer to obtain a signle cell suspension. This suspension is enriched to obtain an enriched protein portion and then separated out to obtain an embryonic celiac antigen (ECA). This ECA is used with serum from patients to effect binding of ECA with IgA in the serum while applying a human IgA antibody to the serum. The results are then read on a spectrophotometer to confirm or negate the presence of celiac disease.

摘要翻译： 在本发明中，提供了一种新的抗原来筛选疑似患有乳糜泻的患者。 通过从人胎盘组织开始制备抗原，该胎盘组织用疱疹和胶原酶缓冲液灌注以获得信号细胞悬液。 将该悬浮液富集以获得富集的蛋白质部分，然后分离出来以获得胚胎性乳糜泻（ECA）。 该ECA与来自患者的血清一起使用，以在血清中施用人IgA抗体，在血清中实现ECA与IgA的结合。 然后在分光光度计上读取结果以确认或否定乳糜泻的存在。

公开(公告)号：US20240133865A1

公开(公告)日：2024-04-25

申请号：US18323844

申请日：2023-05-24

申请人： Laboratory Corporation of America Holdings

发明人： Ute Geigenmuller ,  Doris Damian ,  Maciej Pacula ,  Mark A. DePristo ,  Jeffrey R. Luber

IPC分类号： G01N33/49 ,  G01N33/68 ,  G16H50/20 ,  G16H50/30 ,  G16Z99/00

CPC分类号： G01N33/492 ,  G01N33/6896 ,  G16H50/20 ,  G16H50/30 ,  G16Z99/00 ,  G01N2800/28 ,  G01N2800/38

摘要： In certain embodiments, the invention stems from the discovery that analysis of population distribution curves of metabolite levels in blood can be used to facilitate predicting risk of autism spectrum disorder (ASD) and/or to differentiate between ASD and non-ASD developmental delay (DD) in a subject. In certain aspects, information from assessment of the presence, absence, and/or direction (upper or lower) of a tail effect in a metabolite distribution curve is utilized to predict risk of ASD and/or to differentiate between ASD and DD.

公开(公告)号：US20240019433A1

公开(公告)日：2024-01-18

申请号：US18473600

申请日：2023-09-25

申请人： Quest Diagnostics Investments LLC

发明人： Stanley J. NAIDES ,  Joanna Popov

IPC分类号： G01N33/569 ,  G01N33/68

CPC分类号： G01N33/56944 ,  G01N33/686 ,  G01N33/6893 ,  G01N2800/38 ,  G01N2469/20 ,  G01N2333/315

摘要： Provided are methods for diagnosing a disease in a subject with a previous streptococcal infection by determining the presence or absence of one or more autoantibodies in a biological sample from the subject, wherein the one or more autoantibodies recognize an antigen from a protein selected from the group consisting of ELAVL2, ELAVL3, ELAVL4, Nova-1, Nova-2, Cdr1, Cdr2; and Cdr3. The presence of such autoantibodies is indicative of a positive diagnosis for a post-streptococcal disease such as PANDAS, post-GABHS glomerulonephritis, rheumatic fever, autism and Syndenham's chorea.

公开(公告)号：US20230258663A9

公开(公告)日：2023-08-17

申请号：US17607978

申请日：2020-05-01

申请人： KELLBENX INCORPORATED

发明人： Hassan Bennani

IPC分类号： G01N33/80 ,  C12Q1/6841 ,  G01N1/34 ,  G01N1/30 ,  G01N21/64

CPC分类号： G01N33/80 ,  C12Q1/6841 ,  G01N1/34 ,  G01N1/30 ,  G01N21/6458 ,  G01N21/6428 ,  G01N2800/38 ,  G01N2021/6439

摘要： The disclosure relates to methods of preparation of fetal nucleated red blood cells (NRBCs) from biological samples for diagnostic testing.

公开(公告)号：US20180327805A1

公开(公告)日：2018-11-15

申请号：US15877051

申请日：2018-01-22

申请人： University of Virginia Patent Foundation d/b/a University of Virginia Licensing & Ventures Group

发明人： Karen D. Fairchild ,  Jeffrey Saucerman ,  Randall J. Moorman ,  Douglas E. Lake

IPC分类号： C12Q1/04 ,  G01N33/68

CPC分类号： C12Q1/04 ,  G01N33/6863 ,  G01N33/6869 ,  G01N2333/525 ,  G01N2333/535 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2800/26 ,  G01N2800/38

摘要： A method, system, and computer program product for producing an organism specific diagnosis of septicemia in infants is disclosed. The method involves measuring the levels of one or more biomarkers against predefined threshold values and interpreting these levels to arrive at the diagnosis. Other techniques may introduce a preliminary step of identifying higher risk subjects, as well as the integration of such methods into the final diagnostic methodology. One aspect of a technique of this method may involve measuring one more cytokines to detect specific classes of infective organisms, such as Gram-negative bacteria.