公开(公告)号：US5242814A

公开(公告)日：1993-09-07

申请号：US706901

申请日：1991-05-29

申请人： Raymond C. Yao ,  Robert L. Hamill

发明人： Raymond C. Yao ,  Robert L. Hamill

IPC分类号： A23K20/195 ,  C07H19/01 ,  C12P19/60

CPC分类号： A61K31/70 ,  A23K20/195 ,  C07H19/01 ,  C12P19/60 ,  Y10S435/898

摘要： New polyether antibiotic A80789, its acyl ester, alkyl ester, and alkyl ether derivatives, and salts thereof, are useful as antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80789 by culture of Streptomyces hygroscopicus NRRL 18513, and combinations of the A80789 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and are also provided.

摘要翻译： 新的聚醚抗菌素A80789，其酰基酯，烷基酯和烷基醚衍生物及其盐可用作抗细菌剂和抗球虫剂，并增加动物的饲料利用效率。 通过培养吸水链霉菌NRRL 18513制备A80789的方法，以及A80789化合物与氨基脲，4,4'-二硝基苯胺，某些萘胺和苯胺化合物的组合。

公开(公告)号：US5145781A

公开(公告)日：1992-09-08

申请号：US489566

申请日：1990-03-07

申请人： Yukio Suzuki ,  Kei Suzuki ,  Masaru Yoneyama ,  Hiromi Hijiya ,  Toshio Miyake

发明人： Yukio Suzuki ,  Kei Suzuki ,  Masaru Yoneyama ,  Hiromi Hijiya ,  Toshio Miyake

IPC分类号： A23L1/03 ,  A23L1/275 ,  A61K8/365 ,  A61K8/60 ,  A61K8/67 ,  A61K31/70 ,  A61K31/715 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/10 ,  C07H17/07 ,  C09K15/06 ,  C12P19/18 ,  C12P19/60

CPC分类号： C12P19/60 ,  A23L29/035 ,  A23L5/47 ,  A61K31/70 ,  A61K8/365 ,  A61K8/60 ,  A61K8/67 ,  A61Q19/00 ,  C07H17/07 ,  C09K15/06 ,  C12P19/18 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/02 ,  Y10S514/844

摘要： Alpha-glycosyl rutin is formed at a high concentration by allowing a saccharide-transferring enzyme to act on a high-rutin content liquid in suspension or solution to effect saccharide-transfer reaction. The resultant alpha-glycosyl rutin is easily recovered from the reaction mixture by allowing it to contact with a synthetic macroreticular resin. Alpha-glycosyl rutin is superior in water-solubility, resistance to light and stability to intact rutin, as well as having the physiological activities as intact rutin has. Thus, alpha-glycosyl rutin is favorably usable as a yellow coloring agent, antioxidant, stabilizer, fading-preventing agent, quality-improving agent, preventive, remedy, uv-absorbent and deterioration-preventing agent in foods, beverages, tobaccos, cigarettes, feeds, pet foods, pharmaceuticals for susceptive diseases, cosmetics including skin-refining agent and skin-whitening agent, and plastics, in addition to the use in vitamin P-enriching agents.

公开(公告)号：US5126436A

公开(公告)日：1992-06-30

申请号：US528397

申请日：1990-05-25

申请人： Kenichi Kimura ,  Shoji Nakayama ,  Nobuo Miyata

发明人： Kenichi Kimura ,  Shoji Nakayama ,  Nobuo Miyata

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P31/04 ,  A61P35/00 ,  C07H17/02 ,  C12N1/20 ,  C12P19/60 ,  C12R1/465

CPC分类号： C07H17/02 ,  C12P19/60

摘要： Physiologically active material SN-198C producing bacteria are disclosed which belong to Streptomyces species and products which have the following structural formula: ##STR1##

公开(公告)号：US5108912A

公开(公告)日：1992-04-28

申请号：US560415

申请日：1990-09-10

申请人： May D. Lee ,  Michael Greenstein ,  David P. Labeda ,  Amedeo A. Fantini

发明人： May D. Lee ,  Michael Greenstein ,  David P. Labeda ,  Amedeo A. Fantini

IPC分类号： C07H15/203 ,  C12P19/60

CPC分类号： C07H15/203 ,  C12P19/60 ,  C12R1/29 ,  Y10S435/867 ,  Y10S435/868

摘要： Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora spp. calichensis NRRL-15839, NRRL-15975 and NRRL-18149, are disclosed.

摘要翻译： 名称为LL-E33288复合物的抗菌剂和抗肿瘤剂及其通过新型小单孢菌属（Phonoconospora echinospora spp。）生产。 calichensis NRRL-15839，NRRL-15975和NRRL-18149。

公开(公告)号：US5084563A

公开(公告)日：1992-01-28

申请号：US598484

申请日：1990-10-16

申请人： Shuzo Sakai ,  Masaru Yoneyama ,  Toshio Miyake

发明人： Shuzo Sakai ,  Masaru Yoneyama ,  Toshio Miyake

IPC分类号： C12P19/58 ,  A23L33/15 ,  A61K8/67 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7042 ,  A61K31/7048 ,  A61P3/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/10 ,  C07D307/62 ,  C07H15/26 ,  C07H17/04 ,  C12P19/16 ,  C12P19/18 ,  C12P19/60

CPC分类号： C12P19/60 ,  A61K31/7004 ,  A61K31/7024 ,  A61K8/67 ,  A61K8/676 ,  A61Q19/00 ,  A61Q19/02 ,  C07H17/04 ,  C12P19/16 ,  C12P19/18 ,  C12P19/58 ,  A61Q17/04 ,  A61Q19/10 ,  Y10S435/814 ,  Y10S435/815 ,  Y10S435/816 ,  Y10S435/913 ,  Y10S435/939 ,  Y10S514/844 ,  Y10S514/846

摘要： 2-O-.alpha.-D-Glucopyranosyl-L-ascrobic acid is crystallizable in its supersaturated solution. Crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is substantially nonhygroscopic, free flowing, free of deliquescence, consolidation and direct reducing activity, but is readily soluble in water. Because of these, crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is handleable with an ease, and superiorly high in stability and physiological activities. Thus, crystalline 2-O-.alpha.-D-glucopyranosyl-L-acorbic acid is favorably useful in vitamin C-enriching agents, foodstuffs, pharmaceuticals and cosmetics.

公开(公告)号：US5043353A

公开(公告)日：1991-08-27

申请号：US420508

申请日：1989-10-10

申请人： Raymond C. Yao ,  Robert L. Hamill

发明人： Raymond C. Yao ,  Robert L. Hamill

IPC分类号： A23K20/195 ,  A61K31/35 ,  A61P3/00 ,  C07D493/10 ,  C07H19/01 ,  C12P7/02 ,  C12P7/40 ,  C12P19/60 ,  C12R1/465

CPC分类号： A61K31/70 ,  A23K20/195 ,  C07H19/01 ,  C12P19/60

摘要： New polyether antibiotic A80789, its acyl ester, alkyl ester, and alkyl ether derivatives, and salts thereof, are useful as antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80789 by culture of Streptomyces hygroscopicus NRRL 18513, and combinations of the A80789 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and are also provided.

公开(公告)号：US4683204A

公开(公告)日：1987-07-28

申请号：US658977

申请日：1984-10-09

申请人： LaVerne D. Boeck

发明人： LaVerne D. Boeck

IPC分类号： A23K20/195 ,  C07H19/01 ,  C12P19/44 ,  C12P19/60 ,  C12P13/00 ,  C12N1/20 ,  C12R1/03

CPC分类号： C07H19/01 ,  A23K20/195 ,  C12P19/445 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825

摘要： Improved fermentation process for producing the polyether antibiotic A80190 which comprises cultivating a new strain of Actinomodura Oligospora, NRRL 15878, and the biologically purified culture of this microorganism are provided.

摘要翻译： 提供了用于生产聚醚抗生素A80190的改进的发酵方法，其包括培养新的放线杆菌寡核苷酸NRRL 15878和该微生物的生物纯化培养物。

公开(公告)号：US4552843A

公开(公告)日：1985-11-12

申请号：US581384

申请日：1984-02-17

申请人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

发明人： Walter D. Celmer ,  Walter P. Cullen ,  Hiroshi Maeda ,  Junsuke Tone

IPC分类号： C07D519/00 ,  A23K1/16 ,  A23K1/17 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P3/00 ,  C07H17/04 ,  C07H19/01 ,  C12N1/20 ,  C12P1/00 ,  C12P17/18 ,  C12P19/00 ,  C12P19/44 ,  C12P19/60 ,  C12R1/465 ,  C12P19/62

CPC分类号： C07H19/01 ,  A23K20/195 ,  C12P19/445 ,  C12P19/60 ,  C12R1/465 ,  Y10S435/886

摘要： A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.

摘要翻译： 一种新的酸性多环醚抗生素CP-63,517，具有下式：其中通过唾液链霉菌（Streptomyces endus subsp。）的淹没有氧繁殖产生的阳离子盐。 金黄色葡萄球菌ATCC-39574是从日本土壤样品中分离的新菌株，该抗生素的生产方法及其用于改善饲料利用，促进牛和猪生长以及控制球虫病的方法。

公开(公告)号：US4510134A

公开(公告)日：1985-04-09

申请号：US376046

申请日：1982-05-07

申请人： Irwin B. Wood

发明人： Irwin B. Wood

IPC分类号： A01N43/90 ,  C07H19/01 ,  C12P19/60 ,  A61K31/71 ,  A61K31/35 ,  A61K31/70 ,  A61K35/74

CPC分类号： C07H19/01 ,  A01N43/90 ,  C12P19/60 ,  C12R1/03

摘要： There is provided a method for controlling nematodes in warm-blooded animals by orally administering thereto a nematocidally effective amount of a new antibiotic or mixture of antibiotics produced in a microbiological fermentation under controlled conditions using a newly discovered strain of Actinomadura yumaense and mutants thereof.There is also provided a method for controlling nematodes in soil by applying to said soil a nematocidally effective amount of the above-mentioned antibiotic or antibiotic mixture.

摘要翻译： 提供了一种通过口服施用杀线虫有效量的新生抗生素或在受控条件下在微生物发酵中产生的抗生素混合物的方法，该方法使用新发现的放线菌属（Actinomadura yumaense）及其突变体。 还提供了一种通过向所述土壤施用杀线虫有效量的上述抗生素或抗生素混合物来控制土壤中的线虫的方法。

公开(公告)号：US4363802A

公开(公告)日：1982-12-14

申请号：US325832

申请日：1981-11-30

申请人： Shingo Matsumura, deceased ,  Hiroshi Enomoto ,  Yoshiaki Aoyagi ,  Yoji Ezure ,  Yoshiaki Yoshikuni ,  Shigeaki Maruo ,  Nobutoshi Ojima ,  Kiyotaka Konno

发明人： Shingo Matsumura, deceased ,  Hiroshi Enomoto ,  Yoshiaki Aoyagi ,  Yoji Ezure ,  Yoshiaki Yoshikuni ,  Shigeaki Maruo ,  Nobutoshi Ojima ,  Kiyotaka Konno

IPC分类号： C07D211/46 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P3/08 ,  A61P3/10 ,  C07D405/14 ,  C07H17/02 ,  C12N9/10 ,  C12P19/60 ,  C08B37/00

CPC分类号： C12N9/1074 ,  C07H17/02 ,  C12P19/60 ,  Y10S514/866

摘要： Bisglucosyl moranoline of the formula (I) ##STR1## is useful in inhibiting increase of blood sugar in sugar-loaded animals and humans, and particularly for treatment of diabetes mellitus.

摘要翻译： 式（I）的双葡萄糖基吗啉醇可以用于抑制糖负荷动物和人类的血糖升高，特别是用于治疗糖尿病。