公开(公告)号：US09544956B2

公开(公告)日：2017-01-10

申请号：US14628372

申请日：2015-02-23

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Xuebing Chen ,  Daocheng Huang ,  Qiang Li ,  Fred C. Lee

IPC: H05B33/08

CPC classification number: H05B33/0815 ,  H05B33/0851

Abstract: In a two-stage power converter providing voltage regulation in a first stage, zero voltage switching (ZVS) is provided in switches in an unregulated, constant frequency second stage of a two-stage power converter by an inductor of a CLL resonant circuit connected in parallel with both a series connection of an external inductor and a primary winding of one or more transformers connected in series and an output of the switching circuit so that the output capacitances of the switches can be charged and discharged, respectively, by current in the parallel-connected inductor and independently of current in the magnetizing inductance of the transformer. Therefore, the magnetizing inductance of the transformer can be made sufficiently large to balance currents delivered to respective loads as is particularly desirable for driving a plurality of unbalanced LED strings independently of the value of the parallel-connected inductor which is desirably small.

Abstract translation: 在第一级提供电压调节的两级电力转换器中，通过CLL谐振电路的电感器连接在两级功率转换器的未调节恒定频率第二级的开关中提供零电压开关（ZVS） 与串联连接的一个或多个变压器的外部电感器和初级绕组的串联连接和开关电路的输出两者并联，使得开关的输出电容可以分别由并联的电流充电和放电 并且独立于变压器励磁电感中的电流。 因此，可以使变压器的磁化电感足够大以平衡输送到各个负载的电流，这是特别适合于驱动多个不平衡LED串，独立于期望较小的并联电感器的值。

公开(公告)号：US20160352331A1

公开(公告)日：2016-12-01

申请号：US15178278

申请日：2016-06-09

Applicant: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC. ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Chi-Ming WANG ,  Yincan Mao ,  Zichen Miao ,  Khai Ngo

IPC: H03K17/687

CPC classification number: H03K17/687 ,  H03K17/122

Abstract: Aspects of the disclosure provide a power device that includes an upper power module and a lower power module. The upper power module and the lower power module are coupled in series between two supply voltages, and are respectively controlled by a first control signal and a second control signal. Interconnections of the power device are inductively coupled to prevent reliability issues, such as crosstalk, self turn on, self sustained oscillation, and the like.

Abstract translation: 本公开的方面提供了一种包括上功率模块和下功率模块的功率器件。 上电源模块和下电源模块串联耦合在两个电源电压之间，分别由第一控制信号和第二控制信号控制。 电力设备的互连电感耦合以防止可靠性问题，例如串扰，自启动，自持振荡等。

公开(公告)号：US20160216263A1

公开(公告)日：2016-07-28

申请号：US14946384

申请日：2015-11-19

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Xiang-Jin MENG ,  Yaowei Huang

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  A61K39/12 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/081 ,  C12N7/00 ,  C12N2750/00021 ,  C12N2750/00022 ,  C12N2750/00034 ,  C12N2750/14034 ,  C12Q1/701 ,  G01N2333/01 ,  G01N2333/085 ,  G01N2469/20

Abstract: The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.

Abstract translation: 本发明提供了含有编码猪扭转腱病毒（PTTV）基因型或亚型PTTV1a-VA，PTTV1b-VA，PTTV2b-VA和PTTV2c-VA的多核酸分子的四种纯化制剂。 本发明还提供含有感染性核酸基因组分子的感染性DNA克隆，生物功能质粒或病毒载体。 本发明进一步提供活的，减毒的载体表达和纯化的重组衣壳亚单位或灭活的病毒疫苗以防止PTTV感染。 本发明另外提供了包含PTTV特异性基因产物的亚单位疫苗，特别是用于保护免受PTTV感染的ORF1衣壳基因产物。 此外，本发明提供了使用PTTV1，PTTV2和个体PTTV1基因型的特异性引物通过聚合酶链反应（PCR）诊断PTTV感染的方法。 最后，本发明提供了通过免疫学方法诊断PTTV感染的方法，例如使用PTTV特异性抗原检测血清PTTV特异性抗体的酶联免疫吸附测定（ELISA）和蛋白质印迹。

公开(公告)号：US20160172976A1

公开(公告)日：2016-06-16

申请号：US14957743

申请日：2015-12-03

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Mingkai Mu ,  Sizhao Lu ,  Yang Jiao ,  Fred C. Lee

IPC: H02M3/158 ,  H02M1/14

CPC classification number: H02M7/493 ,  H02M7/487 ,  H02M2001/123

Abstract: Output current ripple is reduced in a three-level DC-DC power converter by connecting a plurality of phase legs in parallel between a source of input power and an output of the power converter and conducting power from the source of input power to the power converter output in an interleaved manner. The large current that results from such interleaved operation is reduced to acceptable levels, potentially less than the output current ripple of the power converter by providing inversely coupled inductors having a mutual inductance preferably greater than the inductor of the power converter in respective phase legs and in series in the circulating current path to avoid any need to increase the power converter inductance due to the circulating current. The inductor and inversely coupled inductors are preferably integrated into a single magnetic element of compact design.

Abstract translation: 在三电平DC-DC电力转换器中，通过在输入电源和功率转换器的输出之间并联连接多个相位支路并将功率从输入电源输入到功率转换器，从而降低输出电流纹波 以交错方式输出。 由这种交错操作产生的大电流通过提供具有互感的反耦合电感，可以降低到可接受的水平，该功率转换器的输出电流纹波可能小于功率转换器的输出电流纹波，所述反耦合电感优选地大于相位相位中的功率转换器的电感器， 串联在循环电流路径中，以避免由于循环电流而增加功率转换器电感。 电感器和反耦合电感器优选地集成到紧凑设计的单个磁性元件中。

公开(公告)号：US20150337388A1

公开(公告)日：2015-11-26

申请号：US14652823

申请日：2013-12-17

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Harold R. Garner, JR. ,  Lauren J. McIver ,  Hongseok Tae

IPC: C12Q1/68 ,  G06F19/22 ,  C40B30/02

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  G16B30/00 ,  G16B35/00 ,  G16C20/60

Abstract: The disclosure provides methods and systems for assessing microsatellites, for identifying informative microsatellite loci, and for using microsatellite data. Microsatellite information has numerous uses including, for example, to characterize disease risk, to predict responsiveness to therapy, and to non-invasively diagnose subjects.

Abstract translation: 本公开提供了用于评估微卫星，识别信息微卫星位点以及使用微卫星数据的方法和系统。 微卫星信息具有许多用途，包括例如表征疾病风险，预测对治疗的反应性和非侵入性诊断受试者。

公开(公告)号：US20150327944A1

公开(公告)日：2015-11-19

申请号：US14808679

申请日：2015-07-24

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Robert E. Neal, II ,  Paulo A. Garcia ,  Rafael V. Davalos ,  John H. Rossmeisl ,  John L. Robertson

IPC: A61B19/00 ,  A61B18/12 ,  A61N1/04

Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

Abstract translation: 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。

公开(公告)号：US20150277460A1

公开(公告)日：2015-10-01

申请号：US14674680

申请日：2015-03-31

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Pei-Hsin Liu ,  Qiang Li ,  Fred C. Lee

IPC: G05F1/56

CPC classification number: G05F1/56 ,  H02M3/1584 ,  H02M2003/1586 ,  H03L7/06

Abstract: In a multi-phase power converter using a phase-locked loop (PLL) arrangement for interleaving of pulse frequency modulated (PFM) pulses of the respective phases, improved transient response, improved stability of high bandwidth output voltage feedback loop, guaranteed stability of the PLL loop and avoidance of jittering and phase cancellation issues are achieved by anchoring the bandwidth at the frequency of peak phase margin. This methodology is applicable to multi-phase power conveners of any number of phases and any known or foreseeable topology for individual phases and is not only applicable to power converters operating under constant on-time control, but is extendable to ramp pulse modulation (RPM) control and hysteresis control. Interleaving of pulses from all phases is simplified through use of phase managers with a reduced number of PLLS using hybrid interleaving arrangements that do not exhibit jittering even when ripple is completely canceled.

Abstract translation: 在使用锁相环（PLL）布置用于交错各相的脉冲频率调制（PFM）脉冲的多相功率转换器中，改进的瞬态响应，改进的高带宽输出电压反馈回路的稳定性，保证了 通过将带宽锚定在峰值相位裕度的频率来实现PLL环路和避免抖动和相位消除问题。 该方法适用于任何阶段的任何阶段的多相功率调节器以及用于各个相的任何已知或可预见的拓扑，并且不仅适用于在恒定导通时间控制下工作的功率转换器，而且可扩展到斜坡脉冲调制（RPM） 控制和滞后控制。 通过使用具有减少数量的PLLS的相位管理器来简化来自所有相的脉冲的交错，即使在纹波被完全取消时也不会出现抖动的混合交错布置。

公开(公告)号：US09146104B2

公开(公告)日：2015-09-29

申请号：US13731378

申请日：2012-12-31

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Colin Smith ,  Shashank Priya

IPC: G01C9/10 ,  G01C9/06

CPC classification number: G01C9/10 ,  G01C2009/068 ,  G01C2009/107

Abstract: Components of an unmanned undersea vehicle are inspired by jellyfish that uses its flexible body and tilt sensing to achieve efficient swimming and turning. A tilt sensor, based on a statocyst, has a metal ball in a chamber lined with resistors. The tilt is sensed in accordance with which resistors the ball contacts. A composition of polyvinyl alcohol hydrogel with ferritin particles dispersed therein mimics the qualities of a jellyfish's mesoglea.

Abstract translation: 无人海底车辆的组成部分灵感来源于水母，使用其灵活的身体和倾斜感应来实现有效的游泳和转动。 一个倾斜传感器，基于一个统计学，在一个内有电阻的一个室内有一个金属球。 根据球接触的哪个电阻来感测倾斜。 其中分散有铁蛋白颗粒的聚乙烯醇水凝胶的组合物模仿水母的中肠的质量。

公开(公告)号：US09119881B2

公开(公告)日：2015-09-01

申请号：US13905888

申请日：2013-05-30

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Josep Bassaganya-Riera ,  Amir J. Guri ,  Raquel Hontecillas

IPC: A61K31/19 ,  A61K31/426 ,  A61K31/4439 ,  A61K47/12 ,  A61K31/425 ,  A61K31/4427 ,  A23L1/30 ,  A61K45/06

CPC classification number: A61K47/12 ,  A23L33/105 ,  A61K31/19 ,  A61K31/425 ,  A61K31/426 ,  A61K31/4427 ,  A61K31/4439 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides combinations, for treatment of subjects suffering from or at high risk of developing diseases and disorders involving expression of peroxisome proliferator-activated receptors (PPAR). The combinations include abscisic acid and one other bioactive agent, which together provide synergistic effects toward treatment or blocking of development of the disease or disorder. In exemplary embodiments, a combination of abscisic acid and a thiazolidinedione (TZD) is provided for increased insulin sensitivity and improved (i.e., reduced) obesity-induced inflammation.

Abstract translation: 本发明提供了用于治疗患有或具有发生涉及过氧化物酶体增殖物激活受体（PPAR）表达的疾病和病症的高风险的受试者的组合。 这些组合包括脱落酸和一种其它生物活性剂，其一起为治疗或阻断疾病或病症发展提供协同效应。 在示例性实施方案中，提供脱落酸和噻唑烷二酮（TZD）的组合用于增加胰岛素敏感性和改善（即减少）肥胖诱导的炎症。

公开(公告)号：US20150207434A1

公开(公告)日：2015-07-23

申请号：US14578651

申请日：2014-12-22

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Jun Wang ,  Rolando Burgos ,  Dushan Boroyevich ,  Bo Wen

IPC: H02M7/797

CPC classification number: H02M7/483 ,  H02M2001/0003 ,  H02M2007/4835

Abstract: In a modular multi-level power converter, additional switching states are interleaved between main switching states that control output voltage or waveform. The additional switching states provide current from a DC-link to charge capacitors in respective modules or cells to an offset voltage from which the capacitor voltages are controlled toward a reference voltage during each switching cycle rather than being allowed to build up over a period of an output waveform of variable line frequency, possibly including zero frequency. Since the switching cycle is much shorter than the duration of a line frequency cycle and the capacitor voltages are balanced during each switching cycle, output voltage ripple can be limited as desired with a capacitor of much smaller value and size than would otherwise be required.

Abstract translation: 在模块化多电平功率转换器中，额外的开关状态在控制输出电压或波形的主开关状态之间交错。 额外的开关状态提供来自DC链路的电流，以将各个模块或单元中的电容器充电到偏移电压，在每个开关周期期间电容器电压从该偏置电压控制到参考电压，而不是允许在 可变线路频率的输出波形，可能包括零频率。 由于开关周期比线路频率周期的持续时间短得多，并且在每个开关周期期间电容器电压平衡，因此可以根据需要以比其它方式要求的更小的值和尺寸的电容器来限制输出电压纹波。