公开(公告)号：US06309419B1

公开(公告)日：2001-10-30

申请号：US09276710

申请日：1999-03-26

Applicant: Eugene de Juan, Jr. ,  R. Scott Rader ,  Terry H. Shelley ,  Andrew N. Lamborne ,  Alexander C. Walsh ,  John K. Niparko

Inventor： Eugene de Juan, Jr. ,  R. Scott Rader ,  Terry H. Shelley ,  Andrew N. Lamborne ,  Alexander C. Walsh ,  John K. Niparko

IPC: A61F218

CPC classification number: A61F2/18 ,  A61F2002/183

Abstract: A tympanic membrane prosthesis is provided that includes, in combination, a generally flat, planar membrane sized to overlay a tear or perforation in the tympanic membrane and having at least one preformed perforation, and at least one mechanical fixation device for fixing the membrane to the tympanic membrane of a patient. Each mechanical fixation device is a tack component including a sharp, piercing distal end, an enlarged proximal end and a shaft extending therebetween. A tack insertion device is provided to guide the tack to and through the tear covering membrane.

Abstract translation: 提供了一种鼓膜假体，其组合包括大致平坦的平面膜，其大小适于覆盖鼓膜中的泪液或穿孔并且具有至少一个预成形穿孔，以及至少一个机械固定装置，用于将膜固定到 患者的鼓膜。 每个机械固定装置是一种粘性部件，包括尖锐的，穿刺的远端，扩大的近端和在它们之间延伸的轴。 提供一种定位插入装置，用于将粘性物引导并穿过泪膜覆盖膜。

公开(公告)号：US6075032A

公开(公告)日：2000-06-13

申请号：US875665

申请日：1998-01-23

Applicant: Peter A. Campochiaro ,  Larry A. Wheeler ,  Roshantha A. Chandraratna ,  Sunil Nagpal ,  Eugene De Juan, Jr.

Inventor： Peter A. Campochiaro ,  Larry A. Wheeler ,  Roshantha A. Chandraratna ,  Sunil Nagpal ,  Eugene De Juan, Jr.

IPC: A61K9/127 ,  A61K9/14 ,  A61K31/19 ,  A61K31/192 ,  A61K31/455 ,  A61K31/465 ,  A61K45/00 ,  A61K47/24 ,  A61P27/02 ,  A61P35/00 ,  A61K31/435 ,  A61K31/07

CPC classification number: A61K31/455 ,  A61K31/192 ,  Y10S514/912

Abstract: Proliferation of retinal pigment epithelium following surgery or trauma or resulting in ocular diseases associated with choroidal neovascularization, such as age related macular degeneration and histoplasmosis syndrome, is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR agonist, preferably one with specific activity for retinoic acid receptors. Preferably the RAR agonist is also a potent antagonist of AP1-dependent gene expression. Alternatively, the proliferation of retinal pigment epithelium is ameliorated with a therapeutic amount of an AP-1 antagonist, alone or in combination with an RAR agonist. The drug can be administered by bolus injection into the vitreous cavity using a dosage from about 50 to 150 .mu.g. Or by slow release from liposomes or an oil tamponade injected into the vitreous cavity. Formulations for preventing proliferation of retinal pigment epithelium are also provided.

Abstract translation: PCT No.PCT / US96 / 01505 Sec。 371日期1998年1月23日 102（e）日期1998年1月23日PCT提交1996年1月31日PCT公布。 公开号WO96 / 23498 日期1996年8月8日通过使视网膜色素上皮细胞与治疗量的视黄酸接触来预防手术或创伤后视网膜色素上皮细胞增生或与脉络膜新生血管形成相关的眼部疾病，如年龄相关性黄斑变性和组织胞浆菌病综合征 受体（RAR激动剂，优选具有对视黄酸受体具有比活性的激动剂），优选地，RAR激动剂也是AP1依赖性基因表达的有效拮抗剂，或者，用治疗量的AP-1改善视网膜色素上皮的增殖 拮抗剂，单独或与RAR激动剂组合，药物可以通过使用约50至150μg的剂量通过快速注射进入玻璃体腔中，或通过从脂质体缓慢释放或注入玻璃体腔的油栓塞来施用。 还提供了用于防止视网膜色素上皮细胞增殖的制剂。

公开(公告)号：US5993072A

公开(公告)日：1999-11-30

申请号：US633428

申请日：1996-04-17

Applicant: Eugene de Juan, Jr. ,  Gregg D. Scheller ,  Michael D. Auld ,  Dyson Hickingbotham

Inventor： Eugene de Juan, Jr. ,  Gregg D. Scheller ,  Michael D. Auld ,  Dyson Hickingbotham

IPC: A61B5/00 ,  G02B6/24 ,  G02B6/38 ,  G02B6/36

CPC classification number: A61B5/0084 ,  G02B6/241 ,  G02B6/3833 ,  A61B2562/228 ,  G02B6/3834 ,  Y10S385/902

Abstract: An assembly of connectors adapt multiple optic fiber illuminators of microsurgical instruments for use with a variety of different available light sources.

Abstract translation: 连接器的组件适应于用于各种不同可用光源的显微外科器械的多个光纤照明器。

公开(公告)号：US10398592B2

公开(公告)日：2019-09-03

申请号：US14129200

申请日：2012-06-28

Applicant: Signe Erickson ,  Darren Doud ,  Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  Kathleen Cogan Farinas

Inventor： Signe Erickson ,  Darren Doud ,  Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  Kathleen Cogan Farinas

IPC: A61M35/00 ,  A61F9/00 ,  A61B10/00

Abstract: An apparatus to treat a patient comprises a container to receive fluid of a device implanted in the eye. The fluid of the device can be analyzed to determine a component of the vitreous humor of the eye.

公开(公告)号：US09107773B2

公开(公告)日：2015-08-18

申请号：US13555056

申请日：2012-07-20

Applicant: Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

Inventor： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC: A61F13/12 ,  A61F9/00 ,  A61F9/013 ,  A61F9/04 ,  A61L27/18 ,  G02C7/04 ,  A61F9/008

CPC classification number: G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

Abstract: A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US08814819B2

公开(公告)日：2014-08-26

申请号：US12970482

申请日：2010-12-16

Applicant: Eugene De Juan, Jr. ,  Stephen Boyd ,  Mark E. Deem ,  Hanson S. Gifford, III ,  Dan Rosenman

Inventor： Eugene De Juan, Jr. ,  Stephen Boyd ,  Mark E. Deem ,  Hanson S. Gifford, III ,  Dan Rosenman

IPC: A61F9/00 ,  A61F9/007 ,  A61K9/00 ,  A61M27/00

CPC classification number: A61F9/00781 ,  A61B34/70 ,  A61B90/00 ,  A61F2/14 ,  A61F2/142 ,  A61F9/0008 ,  A61F9/0017 ,  A61F9/007 ,  A61F9/00736 ,  A61F9/0133 ,  A61F11/00 ,  A61F2250/0001 ,  A61F2250/0096 ,  A61F2250/0097 ,  A61K9/0051 ,  A61M27/002 ,  A61M2202/04 ,  A61M2210/0612

Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

公开(公告)号：US08801649B2

公开(公告)日：2014-08-12

申请号：US12898593

申请日：2010-10-05

Applicant: Eugene De Juan, Jr. ,  Stephen Boyd ,  Mark E. Deem ,  Hanson S. Gifford, III ,  Dan Rosenman

Inventor： Eugene De Juan, Jr. ,  Stephen Boyd ,  Mark E. Deem ,  Hanson S. Gifford, III ,  Dan Rosenman

IPC: A61M27/00 ,  A61B17/32 ,  A61M5/00 ,  A61F9/007 ,  A61F11/00 ,  A61B19/00 ,  A61F2/14

CPC classification number: A61F9/00781 ,  A61B34/70 ,  A61B90/00 ,  A61F2/14 ,  A61F2/142 ,  A61F9/0008 ,  A61F9/0017 ,  A61F9/007 ,  A61F9/00736 ,  A61F9/0133 ,  A61F11/00 ,  A61F2250/0001 ,  A61F2250/0096 ,  A61F2250/0097 ,  A61K9/0051 ,  A61M27/002 ,  A61M2202/04 ,  A61M2210/0612

Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

Abstract translation: 方法和装置适于植入眼睛。 在眼睛的角膜中形成切口，并且通过切口将分路插入眼睛的前房。 分流器包括流体通道。 所述分流器沿着从所述前房通过所述眼睛的巩膜刺入所述脉管外空间的路径通过并且定位在第一位置，使得所述流体通道的第一部分与所述前房连通，并且所述流体通道的第二部分 与脉管外空间连通，以在脉络膜上空间和前房之间提供流体通道。

公开(公告)号：US08734378B2

公开(公告)日：2014-05-27

申请号：US12561680

申请日：2009-09-17

Applicant: Eugene De Juan, Jr. ,  Stephen Boyd ,  Mark E. Deem ,  Hanson S. Gifford, III ,  Dan Rosenman

Inventor： Eugene De Juan, Jr. ,  Stephen Boyd ,  Mark E. Deem ,  Hanson S. Gifford, III ,  Dan Rosenman

IPC: A61F11/00 ,  A61F9/00 ,  A61F9/007 ,  A61F9/013 ,  A61M27/00

CPC classification number: A61F9/00781 ,  A61B34/70 ,  A61B90/00 ,  A61F2/14 ,  A61F2/142 ,  A61F9/0008 ,  A61F9/0017 ,  A61F9/007 ,  A61F9/00736 ,  A61F9/0133 ,  A61F11/00 ,  A61F2250/0001 ,  A61F2250/0096 ,  A61F2250/0097 ,  A61K9/0051 ,  A61M27/002 ,  A61M2202/04 ,  A61M2210/0612

Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

公开(公告)号：US08535333B2

公开(公告)日：2013-09-17

申请号：US12846201

申请日：2010-07-29

Applicant: Eugene de Juan, Jr. ,  Steven John ,  Jose Garcia ,  Richard S. Lilly ,  Thomas A. Silvestrini

Inventor： Eugene de Juan, Jr. ,  Steven John ,  Jose Garcia ,  Richard S. Lilly ,  Thomas A. Silvestrini

IPC: A61F11/00

CPC classification number: A61F9/0017 ,  A61B2090/061 ,  A61B2090/062 ,  A61F9/0026 ,  A61F9/007 ,  A61F9/00781

Abstract: Described herein is a delivery device and methods for delivering an ocular implant into an eye. The delivery device includes a proximal handle portion; a distal delivery portion coupled to a distal end of the handle portion and configured to releasably hold an ocular implant and includes a sheath positioned axially over a guidewire; and a metering system configured to provide visual guidance regarding depth of advancement of an implant positioned on the guidewire into an anatomic region of the eye. Also disclosed is a device and method for loading an implant onto the delivery device.

Abstract translation: 本文描述了用于将眼部植入物递送到眼睛中的递送装置和方法。 输送装置包括近端手柄部分; 远端传送部分，其联接到所述手柄部分的远端并且构造成可释放地保持眼睛植入物并且包括轴向地定位在导丝上的护套; 以及计量系统，其被配置为提供关于定位在所述导丝上的植入物的进展深度到所述眼睛的解剖区域中的视觉指导。 还公开了一种用于将植入物装载到输送装置上的装置和方法。

公开(公告)号：US20120253459A1

公开(公告)日：2012-10-04

申请号：US13366165

申请日：2012-02-03

Applicant: Cary Reich ,  Eugene de Juan, JR. ,  Yair Alster

Inventor： Cary Reich ,  Eugene de Juan, JR. ,  Yair Alster

IPC: A61F2/16

CPC classification number: A61F2/1624 ,  A61F2/1602 ,  A61F2/1635 ,  A61F2/1648 ,  A61F2002/1682 ,  A61F2250/0018 ,  F04C2270/041

Abstract: Described herein are intraocular lenses and methods of implantation. In one aspect, the lens includes a shape changing optical element; a force translation element having a first end region coupled to the optical element and a second end region extending towards a ciliary structure, and an attachment portion coupled to the second end region of the force translation element and configured to contact the ciliary structure. The force translation element is configured to functionally transmit movements of the ciliary structure into a force exerted upon the optical element to effect an accommodating and a disaccommodating change of the optical element.

Abstract translation: 本文描述的是眼内透镜和植入方法。 一方面，透镜包括形状变化光学元件; 力平移元件，其具有联接到所述光学元件的第一端部区域和朝向睫状结构延伸的第二端部区域，以及连接到所述力平移元件的所述第二端部区域并被配置为接触所述睫状结构的附接部分。 力平移元件构造成功能地将睫状结构的运动传递到施加在光学元件上的力，以实现光学元件的容纳和不适应的变化。