知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

2289 records (took 0.044 seconds)

    DRUG DELIVERY DEVICE WITH STERILE FLUID FLOWPATH AND RELATED METHOD OF ASSEMBLY
    92.
    发明公开
    DRUG DELIVERY DEVICE WITH STERILE FLUID FLOWPATH AND RELATED METHOD OF ASSEMBLY 审中-公开

    公开(公告)号：US20230372607A1

    公开(公告)日：2023-11-23

    申请号：US18226414

    申请日：2023-07-26

    Applicant: AMGEN INC.

    Inventor： Yasaman Damestani ,  Lawrence S. Ring

    IPC: A61M5/145 ,  A61M5/24 ,  A61J1/20 ,  A61J1/14 ,  A61M5/28

    CPC classification number: A61M5/1456 ,  A61M5/24 ,  A61J1/2024 ,  A61J1/1406 ,  A61M5/285

    Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device.

    Methods and Systems for Determining a Minimum Number of Cell Line Clones Necessary to Produce a Product Having a Set of Target Product Attributes
    93.
    发明公开
    Methods and Systems for Determining a Minimum Number of Cell Line Clones Necessary to Produce a Product Having a Set of Target Product Attributes 审中-公开

    公开(公告)号：US20230357753A1

    公开(公告)日：2023-11-09

    申请号：US18026264

    申请日：2021-09-09

    Applicant: AMGEN INC.

    Inventor： Huong Thi Ngoc Le ,  Jasmine Tat ,  Ewelina Zasadzinska

    IPC: C12N15/10 ,  G16B25/10 ,  C12M1/36

    CPC classification number: C12N15/1034 ,  C12M41/48 ,  G16B25/10

    Abstract: Methods and systems for determining a minimum number of cell line clones necessary to produce a product having a set of target product attributes are disclosed. An example method includes generating at least one cell line capable of expressing a polypeptide; measuring, using one or more analytical instruments, a plurality of measured product attribute values of a plurality of clones of a candidate cell line; receiving inputs, via a user interface, representing a set of target product attribute values for a product; projecting, by one or more processors based upon the plurality of measured values, a minimum number of subject clones of the product using the candidate cell line necessary to produce a subset of the subject clones having product attributes that satisfy one or more conditions associated with the set of target values; and generating the projected minimum number of subject clones of the product using the candidate cell line.

    Syringe de-capper device
    97.
    发明授权
    Syringe de-capper device 有权

    公开(公告)号：US11771844B2

    公开(公告)日：2023-10-03

    申请号：US17685433

    申请日：2022-03-03

    Applicant: AMGEN INC.

    Inventor： Jeffrey C. Yeary

    IPC: A61M5/32 ,  A61M5/00

    CPC classification number: A61M5/3204 ,  A61M5/002

    Abstract: A syringe de-capper including a base having a lower surface and an upper surface opposite the lower surface. The syringe de-capper also includes a de-capping member extending from the upper surface of the base, the de-capping feature including a proximal end adjacent to the base, a distal end spaced away from the base. The de-capping feature includes opposing first and second lateral surfaces defining a proximal thickness at the proximal end and a distal thickness at the distal end, the distal thickness is smaller than the proximal thickness. Also, the syringe de-capper includes a slot disposed in the de-capping member, the slot extending from the distal end of the de-capping member toward the proximal end of the de-capping member and configured to slidably receive a distal end of a syringe for removing a cap therefrom.

    SWALLOWABLE DRUG DELIVERY DEVICES
    98.
    发明公开
    SWALLOWABLE DRUG DELIVERY DEVICES 审中-公开

    公开(公告)号：US20230302264A1

    公开(公告)日：2023-09-28

    申请号：US18022245

    申请日：2021-09-02

    Applicant: AMGEN INC.

    Inventor： Mehran Mojarrad ,  Scott R. Gibson ,  Scott Castanon ,  Robert Eisele ,  Dylann Ceriani

    IPC: A61M31/00 ,  A61M37/00

    CPC classification number: A61M31/002 ,  A61M37/0015

    Abstract: A swallowable drug delivery device includes a capsule and a tissue attachment member. The capsule may contain a drug and may be sized to pass through at least a portion of the gastrointestinal tract of a patient. The tissue attachment member may be coupled to the capsule. In an initial state, the tissue attachment member may allow the capsule to pass through the at least a portion of the gastrointestinal tract of the patient. In an activated state, the tissue attachment member is configured to at least selectively attach the capsule to a wall of the gastrointestinal tract of the patient. The tissue attachment member may be configured to change from the initial state to the activated state in response to an in vivo condition associated with a predetermined location in the gastrointestinal tract of the patient.

Patent Agency Ranking