公开(公告)号：US12128092B2

公开(公告)日：2024-10-29

申请号：US16995173

申请日：2020-08-17

申请人： Bioverativ Therapeutics Inc.

发明人： Brian M. Thome ,  Cherie Parkhurst-Lang ,  Brandon W. Leveille

IPC分类号： A61K38/36 ,  A61K9/00 ,  A61K9/19 ,  A61K38/48 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  F26B5/06

CPC分类号： A61K38/4846 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  C12Y304/21022 ,  F26B5/06

摘要： The present invention provides, among other things, pre-lyophilization formulations, reconstituted formulations, and lyophilate powder compositions comprising a Factor IX (FIX) polypeptide. The present invention also provides lyophilization methods for producing lyophilate powder comprising a FIX polypeptide.

公开(公告)号：US20240352438A1

公开(公告)日：2024-10-24

申请号：US18685478

申请日：2022-08-26

申请人： DSM Austria GmbH

发明人： Shreenath PRASAD ,  Christoph GONAUS ,  Wulf-Dieter MOLL ,  Gerd SCHATZMAYR ,  Sven BENSON ,  Philipp SCHELLENBERGER ,  Lenz LORENZ

IPC分类号： C12N9/48 ,  A61K38/48

CPC分类号： C12N9/485 ,  A61K38/4813 ,  C12Y304/13009

摘要： The present invention relates to novel uses of the polypeptides and novel variants of said polypeptides capable of detoxifying Ochratoxin A (OTA) and methods (e.g., for detoxifying mycotoxins) based thereon. The present invention further relates to compositions, kits, transgenic plants, transgenic seeds, transgenic pollen grains, foodstuff, intermediate foodstuff; fodder, intermediate fodder; feed, intermediate feed; additive (e.g., foodstuff-, fodder- or feed additive), intermediate additive (e.g., foodstuff-, fodder- or feed intermediate additive); detoxifying agent, intermediate detoxifying agent; nutritional supplement, intermediate nutritional supplement, prebiotic, intermediate prebiotic and/or mixture/s thereof comprising one or more of the polypeptides and/or variants capable of detoxifying Ochratoxin A (OTA).

公开(公告)号：US12121592B2

公开(公告)日：2024-10-22

申请号：US17832196

申请日：2022-06-03

申请人： Translate Bio, Inc.

发明人： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC分类号： A61K48/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  C07K14/505 ,  C07K14/81 ,  C12N9/40 ,  C12N9/64 ,  C12N15/52 ,  C12N15/85

CPC分类号： A61K48/0008 ,  A61K9/0019 ,  A61K9/0073 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/713 ,  A61K38/1816 ,  A61K38/47 ,  A61K38/4846 ,  A61K38/57 ,  A61K48/0075 ,  A61K48/0091 ,  C07K14/505 ,  C07K14/8125 ,  C12N9/2465 ,  C12N9/644 ,  C12N15/52 ,  C12N15/85 ,  C12Y302/01022 ,  C12Y304/21022 ,  A61K48/00

摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20240344047A1

公开(公告)日：2024-10-17

申请号：US18676485

申请日：2024-05-28

申请人： RAMOT AT TEL AVIV UNIVERSITY LTD.

发明人： Maayan GAL ,  Evgeny WEINBERG ,  Inbal SHER ,  Ran TOHAR ,  Tamar ANSBACHER

IPC分类号： C12N9/64 ,  A61K6/50 ,  A61K38/48 ,  A61P1/02

CPC分类号： C12N9/6489 ,  A61K6/50 ,  A61K38/4886 ,  A61P1/02 ,  C12Y304/24003

摘要： Provided herein are modified forms of recombinant collagenase polypeptide having one or more amino acid substitutions and/or deletions compared to a wild type recombinant collagenase protein. Further provided are nucleic acid molecules encoding the modified recombinant collagenase polypeptide, compositions including the same and uses thereof in various dental related procedures.

公开(公告)号：US20240299507A1

公开(公告)日：2024-09-12

申请号：US18414324

申请日：2024-01-16

申请人： Minerva Biotechnologies Corporation

发明人： Cynthia Bamdad

IPC分类号： A61K38/48 ,  A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/54 ,  C07K14/725 ,  C07K16/30

CPC分类号： A61K38/4886 ,  A61K35/17 ,  A61K39/00117 ,  A61P35/00 ,  C07K14/5418 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/7051 ,  C07K16/3092 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/622 ,  C12Y304/24

摘要： The present application discloses humanized antibodies and antibody like proteins and fragments thereof and the use of proteolytic cleavage enzymes.

公开(公告)号：US20240293518A1

公开(公告)日：2024-09-05

申请号：US18439315

申请日：2024-02-12

申请人： Health Research, Inc.

发明人： Yuesheng ZHANG ,  Lu YANG ,  Yun LI

IPC分类号： A61K38/48 ,  A61K39/00 ,  A61K45/06 ,  C12N9/48

CPC分类号： A61K38/4813 ,  A61K39/00 ,  A61K45/06 ,  C12N9/485 ,  C12Y304/13009 ,  C07K2319/21 ,  C07K2319/30

摘要： Provided are compositions and methods for prophylaxis and/or therapy of ErbB2-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase D (PEPD) proteins. The methods include prophylaxis and/or therapy of ErbB2-positive cancer by administering a PEPD to an individual who has or is at risk for developing ErbB2-positive cancer.

公开(公告)号：US20240277819A1

公开(公告)日：2024-08-22

申请号：US18560153

申请日：2022-05-11

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Henry DANIELL ,  Robert P. RICCIARDI

IPC分类号： A61K38/48 ,  A61K9/68 ,  A61K31/728 ,  A61K38/16 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61P31/14 ,  A61P31/16

CPC分类号： A61K38/48 ,  A61K9/0058 ,  A61K31/728 ,  A61K38/168 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61P31/14 ,  A61P31/16 ,  C12Y304/17023

摘要： Compositions and methods for reducing viral load in the oral cavity, particularly Coronavirus such as SARS-CoV-2 and Influenza viral loads are disclosed. Also disclosed are compositions and methods for reducing bacterial or fungal loads in the oral cavity. The compositions comprise a trapping molecule having binding affinity for a protein, glucan, or other molecule on the surface of a virus or microorganism. A carrier appropriate for oral administration, in the form of a chewing gum, long-acting lozenge, or tablet, is further disclosed, to enable easy administration before or after exposure to the infective agent.

公开(公告)号：US20240269300A1

公开(公告)日：2024-08-15

申请号：US18603127

申请日：2024-03-12

申请人： XENETIC BIOSCIENCES, INC.

发明人： Curtis LOCKSHIN

IPC分类号： A61K47/61 ,  A61K38/48 ,  A61K45/06 ,  A61P7/02

CPC分类号： A61K47/61 ,  A61K38/4833 ,  A61K45/06 ,  A61P7/02

摘要： Novel proteins and compounds conjugated with polysialic acid (PSA) are provided herein. Also provided are methods of using these compounds and methods of treatment of various diseases and disorders. The novel compounds provided herein have improved pharmacodynamic and/or pharmacokinetic properties, improved effectiveness, and other desirable properties.

公开(公告)号：US20240269239A1

公开(公告)日：2024-08-15

申请号：US18274166

申请日：2022-01-27

申请人： University of Kansas

发明人： Kyle APLEY ,  Mark FARRELL ,  Cory BERKLAND

IPC分类号： A61K38/28 ,  A61K38/48 ,  A61K47/54 ,  A61K47/60 ,  A61P3/10

CPC分类号： A61K38/28 ,  A61K38/48 ,  A61K39/0008 ,  A61K47/545 ,  A61K47/549 ,  A61K47/60 ,  A61P3/10 ,  C07D249/04 ,  C07H15/26 ,  C07K14/62

摘要： The present disclosure provides conjugates, methods of making the same, and uses thereof. The conjugates of the present technology are useful in inducing anergy in insulin-binding B cells.

公开(公告)号：US12053510B2

公开(公告)日：2024-08-06

申请号：US17052445

申请日：2019-05-01

申请人： ORFONEURO APS

发明人： Jens Morten Fogh ,  Paul Saftig ,  Friederike Zunke ,  André Rosa Alcalde Marques

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61P25/16 ,  A61P25/28

CPC分类号： A61K38/488 ,  A61K9/0019 ,  A61P25/16 ,  A61P25/28

摘要： The invention provides for novel treatments of lysosomal storage diseases, in particular of Neuronal Ceroid Lipofuscinosis (NCL) or synucleinopathy or a disease characterized by block of autophagic flow. The treatment comprises administration of human pro-Cathepsin, in particular human pro-Cathpsin D, B or L to patients in need thereof.