公开(公告)号：US20210169998A1

公开(公告)日：2021-06-10

申请号：US17052445

申请日：2019-05-01

申请人： ORFONEURO APS

发明人： Jens Morten FOGH ,  Paul SAFTIG ,  Friederike ZUNKE ,  André Rosa Alcalde MARQUES

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61P25/16 ,  A61P25/28

摘要： The invention provides for novel treatments of lysosomal storage diseases, in particular of Neuronal Ceroid Lipofuscinosis (NCL) or synucleinopathy or a disease characterized by block of autophagic flow. The treatment comprises administration of human pro-Cathepsin, in particular human pro-Cathpsin D, B or L to patients in need thereof.

公开(公告)号：US12053510B2

公开(公告)日：2024-08-06

申请号：US17052445

申请日：2019-05-01

申请人： ORFONEURO APS

发明人： Jens Morten Fogh ,  Paul Saftig ,  Friederike Zunke ,  André Rosa Alcalde Marques

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61P25/16 ,  A61P25/28

CPC分类号： A61K38/488 ,  A61K9/0019 ,  A61P25/16 ,  A61P25/28

摘要： The invention provides for novel treatments of lysosomal storage diseases, in particular of Neuronal Ceroid Lipofuscinosis (NCL) or synucleinopathy or a disease characterized by block of autophagic flow. The treatment comprises administration of human pro-Cathepsin, in particular human pro-Cathpsin D, B or L to patients in need thereof.