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    Methods and Diets to Protect Against Chemotoxicity and Age Related Illnesses
    2.
    发明申请
    Methods and Diets to Protect Against Chemotoxicity and Age Related Illnesses 审中-公开
    防止化学毒性和年龄相关疾病的方法和饮食

    公开(公告)号：US20160331016A1

    公开(公告)日：2016-11-17

    申请号：US14996946

    申请日：2016-01-15

    申请人： University of Southern California

    发明人： Valter D. LONGO ,  Sebastian BRANDHORST ,  Morgan Elyse LEVINE

    IPC分类号： A23L33/00 ,  A23L33/17 ,  A61K31/4172 ,  A61K31/198 ,  A61K31/401

    CPC分类号： A23L33/40 ,  A23L33/115 ,  A23L33/15 ,  A23L33/155 ,  A23L33/17 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/205 ,  A61K31/23 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172

    摘要： A method of improving longevity and/or alleviating a symptom of aging or preventing age related diseases is provided. The method includes a step in which the subject's average and type of daily protein intake, IGF-I, and IGFBP1 levels, and risk factors for overall mortality, cancer and diabetes are determined. With respect to protein consumption, the relative amounts of protein calories from animal and plant sources are determined. A periodic normal calorie or low calorie but low protein fasting mimicking diet with frequencies of every 2 weeks to 2 months is provided to the subject if the subject's average daily protein intake level and type and/or IGF-I levels, and/or IGFBP1 levels is identified as being greater or lower than a predetermined cutoff intake/level and if the subject is younger than a predetermined age. The method is also shown to alleviate symptoms of chemotoxicity.

    摘要翻译： 提供了改善寿命和/或减轻老化症状或预防年龄相关疾病的方法。 该方法包括一个步骤，其中测定受试者的日常蛋白质摄取量，IGF-I和IGFBP1水平的平均值和类型以及总体死亡率，癌症和糖尿病的危险因素。 关于蛋白质消耗，确定来自动物和植物来源的蛋白质热量的相对量。 如果受试者的平均每日蛋白质摄入水平和类型和/或IGF-1水平和/或IGFBP1水平，则向受试者提供模拟每2周至2个月频率的模拟饮食的周期性正常卡路里或低热量但低蛋白质空腹 被识别为大于或低于预定的截止摄入量/水平，并且如果受试者年龄小于预定年龄。 还显示该方法以减轻化学毒性的症状。

    METHODS AND DIETS TO PROTECT AGAINST CHEMOTOXICITY AND AGE RELATED ILLNESSES
    5.
    发明申请
    METHODS AND DIETS TO PROTECT AGAINST CHEMOTOXICITY AND AGE RELATED ILLNESSES 审中-公开
    防止化学杀伤力和年龄相关疾病的方法和饮食

    公开(公告)号：US20170035094A1

    公开(公告)日：2017-02-09

    申请号：US15298963

    申请日：2016-10-20

    申请人： UNIVERSITY OF SOUTHERN CALIFORNIA

    发明人： Valter D. LONGO ,  Sebastian BRANDHORST ,  Morgan Elyse LEVINE

    IPC分类号： A23L33/00 ,  A23L33/115 ,  A23L33/17 ,  A23L33/155 ,  A23L33/15

    CPC分类号： A23L33/40 ,  A23L33/115 ,  A23L33/15 ,  A23L33/155 ,  A23L33/17 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/205 ,  A61K31/23 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172

    摘要： A method of improving longevity and/or alleviating a symptom of aging or preventing age related diseases is provided. The method includes a step in which the subject's average and type of daily protein intake, IGF-I, and IGFBP1 levels, and risk factors for overall mortality, cancer and diabetes are determined. With respect to protein consumption, the relative amounts of protein calories from animal and plant sources are determined. A periodic normal calorie or low calorie but low protein fasting mimicking diet with frequencies of every 2 weeks to 2 months is provided to the subject if the subject's average daily protein intake level and type and/or IGF-I levels, and/or IGFBP1 levels is identified as being greater or lower than a predetermined cutoff intake/level and if the subject is younger than a predetermined age. The method is also shown to alleviate symptoms of chemotoxicity.

    摘要翻译： 提供了改善寿命和/或减轻老化症状或预防年龄相关疾病的方法。 该方法包括一个步骤，其中测定受试者的日常蛋白质摄取量，IGF-I和IGFBP1水平的平均值和类型以及总体死亡率，癌症和糖尿病的危险因素。 关于蛋白质消耗，确定来自动物和植物来源的蛋白质热量的相对量。 如果受试者的平均每日蛋白质摄入水平和类型和/或IGF-I水平和/或IGFBP1水平，则向受试者提供模拟每2周至2个月频率的饮食的周期性正常卡路里或低卡路里低蛋白质空腹模拟饮食 被识别为大于或低于预定的截止摄入量/水平，并且如果受试者年龄小于预定年龄。 还显示该方法以减轻化学毒性的症状。

    Methods and Diets to Protect Against Chemotoxicity and Age Related Illnesses
    6.
    发明申请
    Methods and Diets to Protect Against Chemotoxicity and Age Related Illnesses 有权
    防止化学毒性和年龄相关疾病的方法和饮食

    公开(公告)号：US20140227373A1

    公开(公告)日：2014-08-14

    申请号：US14178953

    申请日：2014-02-12

    申请人： University of Southern California

    发明人： Valter D. LONGO ,  Sebastian BRANDHORST ,  Morgan Elyse LEVINE

    IPC分类号： A23L1/29

    CPC分类号： A23L33/40 ,  A23L33/115 ,  A23L33/15 ,  A23L33/155 ,  A23L33/17 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/205 ,  A61K31/23 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4172

    摘要： A method of improving longevity and/or alleviating a symptom of aging or preventing age related diseases is provided. The method includes a step in which the subject's average and type of daily protein intake, IGF-I, and IGFBP1 levels, and risk factors for overall mortality, cancer and diabetes are determined. With respect to protein consumption, the relative amounts of protein calories from animal and plant sources are determined. A periodic normal calorie or low calorie but low protein fasting mimicking diet with frequencies of every 2 weeks to 2 months is provided to the subject if the subject's average daily protein intake level and type and/or IGF-I levels, and/or IGFBP1 levels is identified as being greater or lower than a predetermined cutoff intake/level and if the subject is younger than a predetermined age. The method is also shown to alleviate symptoms of chemotoxicity.

    摘要翻译： 提供了改善寿命和/或减轻老化症状或预防年龄相关疾病的方法。 该方法包括一个步骤，其中测定受试者的日常蛋白质摄取量，IGF-I和IGFBP1水平的平均值和类型以及总体死亡率，癌症和糖尿病的危险因素。 关于蛋白质消耗，确定来自动物和植物来源的蛋白质热量的相对量。 如果受试者的平均每日蛋白质摄入水平和类型和/或IGF-I水平和/或IGFBP1水平，则向受试者提供模拟每2周至2个月频率的饮食的周期性正常卡路里或低卡路里低蛋白质空腹模拟饮食 被识别为大于或低于预定的截止摄入量/水平，并且如果受试者年龄小于预定年龄。 还显示该方法以减轻化学毒性的症状。

    METHODS AND FORMULATIONS PROMOTING TISSUE/ORGAN REGENERATION, LONGEVITY AND HEALTHSPAN
    7.
    发明申请
    METHODS AND FORMULATIONS PROMOTING TISSUE/ORGAN REGENERATION, LONGEVITY AND HEALTHSPAN 有权
    促进组织/组织再生，长期和健康的方法和制剂

    公开(公告)号：US20140112909A1

    公开(公告)日：2014-04-24

    申请号：US14060494

    申请日：2013-10-22

    申请人： University of Southern California

    发明人： Valter D. LONGO ,  Chia Wei CHENG ,  Sebastian BRANDHORST ,  Min WEI

    IPC分类号： A23L1/29 ,  A61K45/00

    CPC分类号： A23L33/40 ,  A23L29/37 ,  A23L33/115 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/17 ,  A23L33/175 ,  A23L33/30 ,  A23V2002/00 ,  A61K45/00

    摘要： A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.

    摘要翻译： 一种方法包括识别需要饮食修饰的受试者的步骤; 以及对所述受试者施用第一次饮食第一次。 第一次饮食在头一天的第二天至第五天每天每磅主题每天提供4.5至7千卡每天的主题，每天每磅3至5千卡。 第一天的饮食包括第一天少于30克的糖; 第二至第五天少于20克糖; 第一天少于28克蛋白质; 第二至第五天天数少于18克; 第一天20至30克单不饱和脂肪; 第二至第五天10至15克单不饱和脂肪; 和第一天6至10克多不饱和脂肪之间。