公开(公告)号：US09642916B2

公开(公告)日：2017-05-09

申请号：US13803878

申请日：2013-03-14

Applicant: The Regents of the University of California

Inventor： Kit S. Lam ,  Yuanpei Li ,  Chong-Xian Pan ,  Tzu-yin Lin

IPC: A61K47/42 ,  A61K47/48 ,  A61K49/04 ,  B82Y5/00 ,  A61K31/704 ,  A61K41/00 ,  A61K49/00 ,  A61K51/08 ,  A61K51/12 ,  A61N5/06

CPC classification number: A61K47/60 ,  A61K31/704 ,  A61K41/0033 ,  A61K41/0052 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/62 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0002 ,  A61K49/0036 ,  A61K49/0082 ,  A61K49/0423 ,  A61K49/1809 ,  A61K51/1227 ,  A61N5/062 ,  B82Y5/00

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US20140161719A1

公开(公告)日：2014-06-12

申请号：US13803878

申请日：2013-03-14

Applicant: The Regents of the University of California

Inventor： Kit S. Lam ,  Yuanpei Li ,  ChongXian Pan ,  Tzu-yin Lin

IPC: A61K47/42

CPC classification number: A61K47/60 ,  A61K31/704 ,  A61K41/0033 ,  A61K41/0052 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/62 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0002 ,  A61K49/0036 ,  A61K49/0082 ,  A61K49/0423 ,  A61K49/1809 ,  A61K51/1227 ,  A61N5/062 ,  B82Y5/00

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Abstract translation: 本发明提供了聚合形成以疏水核心和亲水外部为特征的纳米载体的两亲性的前体衍生物。 纳米载体核可以包括两亲官能团，例如胆酸或胆酸衍生物，并且外部可以包括支链或直链的聚（乙二醇）链段。 纳米载体如疏水性药物和其他材料可以通过非共价方式螯合在核心中，或者可以共价结合到四聚体上。 Teendendrimer结构可以被定制以改变负载特性，与诸如生物膜的材料的相互作用以及其它特征。