公开(公告)号：US10913696B2

公开(公告)日：2021-02-09

申请号：US16847193

申请日：2020-04-13

申请人： DOW GLOBAL TECHNOLOGIES LLC ,  The REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Melanie S. Sanford ,  Douglas Bland ,  Patrick S. Hanley ,  Megan A. Cismesia ,  Sydonie D. Schimler

IPC分类号： C07C17/02 ,  C07D453/02 ,  C07D311/16 ,  C07C17/093 ,  C07D209/08 ,  C07D213/79 ,  C07D213/61 ,  C07C231/12 ,  C07C41/22 ,  C07C45/63 ,  C07D213/57 ,  C07C201/12 ,  C07C67/307 ,  C07D213/75 ,  C07J21/00 ,  C07D279/16 ,  C07C253/30 ,  C07D209/88 ,  C07D215/18 ,  C07C25/13 ,  C07C317/14

摘要： Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species.
Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species.
Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.

公开(公告)号：US10071943B2

公开(公告)日：2018-09-11

申请号：US15303087

申请日：2015-04-10

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Peter J. H. Scott ,  Melanie S. Sanford ,  Naoko Ichiishi ,  Allen F. Brooks ,  Melissa Rodnick ,  Joseph J. Topczewski

IPC分类号： C07C41/22 ,  A61K51/04 ,  C07B59/00 ,  C07C231/12 ,  C07C233/51 ,  C07C67/307 ,  C07C45/63 ,  C07C17/361 ,  C07C51/363 ,  C07J1/00

CPC分类号： C07C41/22 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0493 ,  C07B59/00 ,  C07B2200/05 ,  C07C17/361 ,  C07C45/63 ,  C07C51/363 ,  C07C67/307 ,  C07C231/12 ,  C07C233/51 ,  C07J1/0066 ,  C07C233/15 ,  C07C69/76 ,  C07C47/55 ,  C07C43/225

摘要： Copper-catalyzed radiofluorination of iodonium salts, iodonium salts, and compounds obtained by copper-catalyzed radiofluorination of iodonium salts are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.

公开(公告)号：US11056705B2

公开(公告)日：2021-07-06

申请号：US15580048

申请日：2016-06-08

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Melanie S. Sanford ,  Christo Slavov Sevov ,  Rachel Brooner ,  Etienne Chénard

IPC分类号： H01M8/18 ,  C07D213/55 ,  C07D213/89 ,  C07F5/02 ,  H01M4/36 ,  H01M10/0569 ,  H01M10/0567 ,  H01M2/14 ,  C07D213/56 ,  C07D213/51 ,  H01M4/90 ,  H01M50/40

摘要： Organic anolyte materials for redox flow batteries and redox flow batteries containing organic anolyte materials are disclosed.

公开(公告)号：US20180138539A1

公开(公告)日：2018-05-17

申请号：US15580048

申请日：2016-06-08

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Melanie S. Sanford ,  Christo Slavov Sevov ,  Rachel Brooner ,  Etienne Chénard

IPC分类号： H01M8/18 ,  C07D213/55 ,  C07D213/89 ,  C07D213/56 ,  C07F5/02 ,  H01M4/36 ,  H01M10/0569 ,  H01M10/0567 ,  H01M2/14

CPC分类号： H01M8/188 ,  C07D213/51 ,  C07D213/55 ,  C07D213/56 ,  C07D213/89 ,  C07F5/022 ,  H01M2/14 ,  H01M4/368 ,  H01M4/9008 ,  H01M10/0567 ,  H01M10/0569 ,  H01M2300/0028 ,  Y02E60/528

摘要： Organic anolyte materials for redox flow batteries and redox flow batteries containing organic anolyte materials are disclosed.

公开(公告)号：US20160317682A1

公开(公告)日：2016-11-03

申请号：US15142131

申请日：2016-04-29

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Peter J. H. Scott ,  Allen F. Brooks ,  Naoko Ichiishi ,  Melanie S. Sanford

IPC分类号： A61K51/04 ,  C07C227/16 ,  C01G5/00 ,  C07C17/20

CPC分类号： A61K51/04 ,  A61K51/0402 ,  C01G5/003 ,  C01P2006/88 ,  C07B59/001 ,  C07C17/208 ,  C07C209/74 ,  C07C227/16 ,  C07C25/18 ,  C07C229/36 ,  C07C211/52

摘要： Copper-catalyzed radiofluorination of aryl iodides using Ag18F, methods of preparing Ag18F, and compounds obtained by copper-catalyzed radiofluorination of aryl iodides using Ag18F are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.

摘要翻译： 公开了使用Ag18F的芳基碘化物的铜催化放射性氟化，制备Ag18F的方法，以及使用Ag18F通过铜催化的芳基碘化物的放射性氟化获得的化合物。 还公开了涉及这些化合物的诊断和治疗方法。

公开(公告)号：US11230517B2

公开(公告)日：2022-01-25

申请号：US17015775

申请日：2020-09-09

申请人： DOW GLOBAL TECHNOLOGIES LLC ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Melanie S. Sanford ,  Douglas Bland ,  Patrick S. Hanley ,  Megan A. Cismesia ,  Sydonie D. Schimler

IPC分类号： C07C17/02 ,  C07D453/02 ,  C07D311/16 ,  C07C17/093 ,  C07D209/08 ,  C07D213/79 ,  C07D213/61 ,  C07C231/12 ,  C07C41/22 ,  C07C45/63 ,  C07D213/57 ,  C07C201/12 ,  C07C67/307 ,  C07D213/75 ,  C07J21/00 ,  C07D279/16 ,  C07C253/30 ,  C07D209/88 ,  C07D215/18 ,  C07C25/13 ,  C07C317/14

摘要： Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species.
Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species.
Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.

公开(公告)号：US11059782B2

公开(公告)日：2021-07-13

申请号：US16317336

申请日：2017-07-13

申请人： DOW GLOBAL TECHNOLOGIES LLC ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Melanie S. Sanford ,  Megan A. Cismesia ,  Patrick S. Hanley ,  Douglas Bland

IPC分类号： C07D213/30 ,  C07B39/00 ,  C07C49/215 ,  C07C211/63 ,  C07D221/04 ,  C07D215/18 ,  C07C45/63 ,  C07C45/61 ,  C07D213/79

摘要： Disclosed is a fluorination method comprising providing a fluorinating reagent and a solvent to a reaction mixture; providing a compound having the formula Ar—X to the reaction mixture; wherein Ar is aryl, substituted aryl, heteroaryl or substituted heteroaryl, and X is Cl, Br, I or NO2, providing tetramethylammonium 2,6-dimethylphenolate to the reaction mixture; and reacting under conditions sufficient to provide a species having the formula Ar—F.

公开(公告)号：US20170036980A1

公开(公告)日：2017-02-09

申请号：US15303087

申请日：2015-04-10

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Peter J. H. Scott ,  Melanie S. Sanford ,  Naoko Ichiishi ,  Allen F. Brooks ,  Melissa Rodick ,  Joseph J. Topczewski

IPC分类号： C07C41/22 ,  C07C17/361 ,  A61K51/04 ,  C07C67/307 ,  C07C51/363 ,  C07C231/12 ,  C07J1/00

CPC分类号： C07C41/22 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0493 ,  C07B59/00 ,  C07B2200/05 ,  C07C17/361 ,  C07C45/63 ,  C07C51/363 ,  C07C67/307 ,  C07C231/12 ,  C07C233/51 ,  C07J1/0066 ,  C07C233/15 ,  C07C69/76 ,  C07C47/55 ,  C07C43/225

摘要： Copper-catalyzed radiofluorination of iodonium salts, iodonium salts, and compounds obtained by copper-catalyzed radiofluorination of iodonium salts are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.

摘要翻译： 公开了铜催化的碘鎓盐，碘鎓盐和通过铜催化的碘鎓放氢氟化得到的化合物的放射性氟化。 还公开了涉及这些化合物的诊断和治疗方法。