-
公开(公告)号：US20210199226A1
公开(公告)日：2021-07-01
申请号：US17127198
申请日：2020-12-18
Inventor： Jianfeng ZHANG , Jian L. Ding , Rachel Z. Pytel
IPC: F16L53/34
Abstract: A multi-lumen article includes at least two profiles including at least two lumen, wherein the at least two profiles include a first profile and a second profile, the first profile including a first end and a first lumen, wherein the first lumen provides a fluid flow in a first path; and the second profile including a second end and a second lumen, wherein the second lumen provides a fluid flow in a distinct path different than the first path, wherein at least one profile comprises a polymeric material, wherein the first end and the second end are coincidently bonded without a bonding material at an interface at the first end and the second end.
-
公开(公告)号：US20220204901A1
公开(公告)日：2022-06-30
申请号：US17564949
申请日：2021-12-29
Inventor： Katie Campbell , Natalie Fekete , Lei Zhang , Rachel Z. Pytel , Robert Gordon Pleydon
Abstract: The disclosure relates generally to a cell culture apparatus and a cell culture method. One aspect of the disclosure is an oxygen-permeable bag comprising one or more polymer films defining a boundary of an interior compartment of the bag, each of the one or more polymer films comprising an inner layer adjacent the interior compartment of the bag, the inner layer comprising a fluoropolymer, and adhered to the inner layer, an outer layer comprising polymer; a first port formed in an exterior surface of the bag and in fluid communication with the interior compartment; a second port formed in an exterior surface of the bag and in fluid communication with the interior compartment; and contained in the interior compartment, a plurality of microcarriers.
-
公开(公告)号：US20200209233A1
公开(公告)日：2020-07-02
申请号：US16730660
申请日：2019-12-30
Inventor： Katie Campbell , Natasha Anna Boghosian , Natalie Fekete , Rachel Z. Pytel
IPC: G01N33/543
Abstract: This disclosure relates to containers (e.g., in the form of bags) comprising a fluoropolymer and containing a degradable carrier comprising biological agent-capturing moieties, to cell isolation systems comprising such containers, and to methods for cultivating a biological agent using such containers. In one embodiment, the disclosure provides a container having an outer surface and an inner surface, the inner surface comprising a fluoropolymer, and contained in the container, a degradable carrier; wherein the carrier comprises a plurality of biological agent-capturing moieties.
-
公开(公告)号：US12226846B2
公开(公告)日：2025-02-18
申请号：US17182669
申请日：2021-02-23
Inventor： Jianfeng Zhang , Rachel Z. Pytel , Jian L. Ding , Anthony P. Pagliaro , Clemens E. Zoellner
IPC: B23K10/02 , B29C65/20 , H05H1/26 , B23K103/00
Abstract: Systems and methods are disclosed that include an operation chamber, a plasma generator having at least one plasma head disposed within the operation chamber and in proximity to a profile formed by cutting a piece of tubing, and a mechanical motion module. The plasma generator generates a plasma treatment and applies the plasma treatment via the at least one plasma head to the profile to activate material on an end surface of the profile, within a lumen of the profile, or a combination thereof. Once the material of the profile is activated by the plasma treatment, the mechanical motion module manipulates the profile to close the lumen of the profile to aseptically seal the profile.
-
公开(公告)号：US12180444B2
公开(公告)日：2024-12-31
申请号：US17136400
申请日：2020-12-29
Inventor： Katie Campbell , Natalie Fekete , Rachel Z. Pytel
Abstract: This disclosure relates generally to containers (such as bags) having surfaces comprising one or more aptamer sequences. More particularly, the present disclosure relates to containers such as bags comprising a fluoropolymer attached to aptamer sequences having binding affinity for one or more biological agents, and to transductions methods using such containers. In one aspect, the disclosure provides a container (e.g., a bag) having an outer surface and an inner surface, the inner surface comprising a fluoropolymer; attached to the fluoropolymer, a plurality of functional groups; and attached to each of at least a portion of the functional groups, a first aptamer sequence having a binding affinity for a viral vector.
-
Patent Agency Ranking
公开(公告)号：US11845230B2
公开(公告)日：2023-12-19
申请号：US16918345
申请日：2020-07-01
Inventor： Jianfeng Zhang , Rachel Z. Pytel , Jian L. Ding
IPC: A61M39/00 , B32B15/06 , B29C65/14 , B29C65/00 , B29K9/06 , B29K105/00 , B29K223/00 , B29L23/00 , B32B25/04 , F16L13/02
CPC classification number: B29C65/1432 , A61M39/00 , B29C66/00143 , B29C66/71 , B29C66/73921 , B29C66/73941 , B29K2009/06 , B29K2105/0088 , B29K2223/06 , B29K2223/12 , B29L2023/005 , B32B15/06 , B32B25/042 , F16L13/02
Abstract: A connection includes: a first profile having a first end, the first profile including a first polymeric material comprising a thermoset material; and a second profile having a second end, the second profile including a second polymeric material, a metal, or combination thereof, wherein the first end and the second end are coincidently bonded without a bonding material at an interface of the first end and the second end.
-
公开(公告)号：US20210001566A1
公开(公告)日：2021-01-07
申请号：US16918345
申请日：2020-07-01
Inventor： Jianfeng ZHANG , Rachel Z. Pytel , Jian L. Ding
IPC: B29C65/00
Abstract: A connection includes: a first profile having a first end, the first profile including a first polymeric material comprising a thermoset material; and a second profile having a second end, the second profile including a second polymeric material, a metal, or combination thereof, wherein the first end and the second end are coincidently bonded without a bonding material at an interface of the first end and the second end.
-
公开(公告)号：US12049978B2
公开(公告)日：2024-07-30
申请号：US17130167
申请日：2020-12-22
Inventor： Jianfeng Zhang , Rachel Z. Pytel , Jian L. Ding
CPC classification number: F16L55/1003 , F16L11/12
Abstract: A profile includes: a sidewall, a lumen for a fluid path, and an end, the profile including a thermoset material, wherein the profile includes a sealed end without an external bonding material, wherein the sealed end withstands a seal integrity pressure test of at least 1 psi, such as at least 5 psi, such as at least 10 psi, such as at least 15 psi, or even at least 20 psi air pressure for about 30 minutes under dry and wet conditions.
-
公开(公告)号：US20210291291A1
公开(公告)日：2021-09-23
申请号：US17182669
申请日：2021-02-23
Inventor： Jianfeng Zhang , Rachel Z. Pytel , Jian L. Ding , Anthony P. Pagliaro , Clemens E. Zoellner
Abstract: Systems and methods are disclosed that include an operation chamber, a plasma generator having at least one plasma head disposed within the operation chamber and in proximity to a profile formed by cutting a piece of tubing, and a mechanical motion module. The plasma generator generates a plasma treatment and applies the plasma treatment via the at least one plasma head to the profile to activate material on an end surface of the profile, within a lumen of the profile, or a combination thereof. Once the material of the profile is activated by the plasma treatment, the mechanical motion module manipulates the profile to close the lumen of the profile to aseptically seal the profile.
-
公开(公告)号：US20210198606A1
公开(公告)日：2021-07-01
申请号：US17136400
申请日：2020-12-29
Inventor： Katie Campbell , Natalie Fekete , Rachel Z. Pytel
Abstract: This disclosure relates generally to containers (such as bags) having surfaces comprising one or more aptamer sequences. More particularly, the present disclosure relates to containers such as bags comprising a fluoropolymer attached to aptamer sequences having binding affinity for one or more biological agents, and to transductions methods using such containers. In one aspect, the disclosure provides a container (e.g., a bag) having an outer surface and an inner surface, the inner surface comprising a fluoropolymer; attached to the fluoropolymer, a plurality of functional groups; and attached to each of at least a portion of the functional groups, a first aptamer sequence having a binding affinity for a viral vector.
-
-
-
-
-
-
-
-
-
Search Results
12
records
(took 0.016 seconds)
