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    Method and apparatus for automated spectral calibration
    1.
    发明授权
    Method and apparatus for automated spectral calibration 有权
    用于自动光谱校准的方法和装置

    公开(公告)号：US08440959B2

    公开(公告)日：2013-05-14

    申请号：US12897376

    申请日：2010-10-04

    Applicant: Matthew Nelson ,  Patrick Treado

    Inventor： Matthew Nelson ,  Patrick Treado

    IPC: G01D18/00

    CPC classification number: A61B5/0059 ,  A61B2560/0223 ,  G01J3/28 ,  G01J3/42

    Abstract: A method and apparatus for automated spectral calibration of a spectroscopy device. A method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.

    Abstract translation: 一种用于光谱装置的自动光谱校准的方法和装置。 一种通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。

    System and method for component discrimination enhancement based on multispectral addition imaging
    2.
    发明授权
    System and method for component discrimination enhancement based on multispectral addition imaging 有权
    基于多光谱加法成像的组件鉴别增强的系统和方法

    公开(公告)号：US08289513B2

    公开(公告)日：2012-10-16

    申请号：US12799779

    申请日：2010-04-30

    Applicant: Matthew Nelson ,  Patrick Treado ,  Charles W. Gardner, Jr.

    Inventor： Matthew Nelson ,  Patrick Treado ,  Charles W. Gardner, Jr.

    IPC: G01J3/28

    CPC classification number: G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/16 ,  G02B21/361

    Abstract: A system and method for performing multispectral color addition imaging. An optical image is obtained for a sample scene comprising one or more target materials. Spectroscopic data is obtained for one or more target materials. A first and second waveband of interest are obtained for one or more target materials. A ratio of the first and second wavebands of interest is obtained and compared to one or more ranges of threshold values. Based on this comparison, a result is displayed wherein this result comprises a pseudo color overlay on said optical image. The pseudo color image may comprise one or more pseudo colors assigned to one or more target materials so as to differentiate and identify the target materials present in the sample scene.

    Abstract translation: 用于执行多光谱彩色加成成像的系统和方法。 获得包含一个或多个目标材料的样本场景的光学图像。 获得一种或多种目标材料的光谱数据。 获得针对一种或多种目标材料的第一和第二感兴趣波段。 获得感兴趣的第一和第二波段的比率并将其与一个或多个阈值范围进行比较。 基于该比较，显示结果，其中该结果包括所述光学图像上的伪颜色覆盖。 伪彩色图像可以包括分配给一个或多个目标材料的一种或多种伪颜色，以便区分和识别存在于样本场景中的目标材料。

    Spatially and spectrally parallelized fiber array spectral translator system and method of use
    3.
    发明授权
    Spatially and spectrally parallelized fiber array spectral translator system and method of use 有权
    空间和光谱平行化的光纤阵列光谱转换系统及其使用方法

    公开(公告)号：US08098373B2

    公开(公告)日：2012-01-17

    申请号：US12759082

    申请日：2010-04-13

    Applicant: Matthew Nelson ,  Patrick Treado ,  Ryan Priore

    Inventor： Matthew Nelson ,  Patrick Treado ,  Ryan Priore

    IPC: G01J3/28

    CPC classification number: G01J3/36 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/2823 ,  G01N21/31 ,  G01N2201/0833 ,  G01N2201/0846

    Abstract: System and method for spatially and spectrally parallelized FAST. A sample is illuminated to thereby produce interacted photons. The photons are passed through a filter and received at a two-dimensional end of a FAST device wherein said FAST device comprises a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack so as to effectively convert a two-dimensional array of optical fibers into a curvilinear field of view, and wherein said two-dimensional array of optical fibers is configured to receive said photons and transfer said photons out of said fiber array spectral translator device and to a spectrograph through said one-dimensional fiber stack wherein said one-dimensional fiber stack comprises at least two columns of fibers spatially offset in parallel at the entrance slit of said spectrograph. The photons are then detected at a detector to thereby obtain a spectroscopic data set representative of the sample.

    Abstract translation: 用于空间和光谱平行化FAST的系统和方法。 照射样品从而产生相互作用的光子。 光子通过过滤器并在FAST装置的二维端接收，其中所述FAST装置包括被拉入一维纤维堆叠的二维光纤阵列，以有效地将二维阵列 的光纤变成曲线视场，并且其中所述二维光纤阵列被配置为接收所述光子并将所述光子从所述光纤阵列光谱转换器装置传送到通过所述一维光纤堆的光谱仪，其中 所述一维纤维堆叠包括在所述光谱仪的入口狭缝处空间上平行偏移的至少两列纤维。 然后在检测器处检测光子，从而获得代表样品的光谱数据集。

    Method and Apparatus for Multimodal Detection
    4.
    发明申请
    Method and Apparatus for Multimodal Detection 有权
    多模态检测方法与装置

    公开(公告)号：US20100217537A1

    公开(公告)日：2010-08-26

    申请号：US12718362

    申请日：2010-03-05

    Applicant: Jason Neiss ,  Patrick Treado ,  Robert C. Schweitzer

    Inventor： Jason Neiss ,  Patrick Treado ,  Robert C. Schweitzer

    IPC: G01J3/44 ,  G06F19/00

    CPC classification number: G01J3/28

    Abstract: System and method for assessing the occurrence of an unknown substance in a sample that comprises multiple entities. A reference library is provided comprising a plurality of reference data sets representative of at least one known substance. A first feature of the entities is assessed wherein the first feature is characteristic of the unknown substance. A region of interest is selected wherein the region of interest comprises at least one entity exhibiting the first feature. A spatially accurate wavelength resolved Raman image is obtained wherein each pixel in the image is the Raman spectrum of the sample at the corresponding location. The spatially accurate wavelength resolved image is assessed to thereby identify the unknown substance.

    Abstract translation: 用于评估包含多个实体的样品中未知物质的发生的系统和方法。 提供了包括代表至少一种已知物质的多个参考数据集的参考文库。 评估实体的第一特征，其中第一特征是未知物质的特征。 选择感兴趣区域，其中感兴趣区域包括展示第一特征的至少一个实体。 获得空间精确的波长分辨拉曼图像，其中图像中的每个像素是相应位置处样品的拉曼光谱。 评估空间上准确的波长分辨图像，从而识别未知物质。

    Method and apparatus for a microscope image selector
    6.
    发明授权
    Method and apparatus for a microscope image selector 有权
    显微镜图像选择器的方法和装置

    公开(公告)号：US07414725B2

    公开(公告)日：2008-08-19

    申请号：US11902874

    申请日：2007-09-26

    Applicant: Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    Inventor： Xinghua Wang ,  Thomas Voigt ,  David Tuschel ,  Chenhui Wang ,  Patrick Treado

    IPC: G01N21/25 ,  G02B21/00

    CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    Abstract: The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    Abstract translation: 本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。 在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像 选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

    Automated acquisition of spectral data and image data
    7.
    发明申请
    Automated acquisition of spectral data and image data 有权
    自动采集光谱数据和图像数据

    公开(公告)号：US20070133984A1

    公开(公告)日：2007-06-14

    申请号：US11585535

    申请日：2006-10-24

    Applicant: John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    Inventor： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    IPC: H04B10/08 ,  H04B17/00

    CPC classification number: G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

    Abstract: A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

    Abstract translation: 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

    Ultrasonic spray deposition of analytes for improved molecular chemical imaging detection
    9.
    发明申请
    Ultrasonic spray deposition of analytes for improved molecular chemical imaging detection 审中-公开
    分析物的超声波喷雾沉积用于改进分子化学成像检测

    公开(公告)号：US20070070342A1

    公开(公告)日：2007-03-29

    申请号：US11527391

    申请日：2006-09-27

    Applicant: Patrick Treado

    Inventor： Patrick Treado

    IPC: G01J3/44 ,  G01N1/00 ,  G01N21/65

    CPC classification number: G01N21/27 ,  G01J3/44 ,  G01J3/443 ,  G01N21/65

    Abstract: A device and method is described that uses an ultrasonic nozzle for high efficiency deposition of an analyte. Certain embodiments include a plurality of spray applications over the same spatial location to thereby increase the analyte concentration so as to localize and improve the overall molecular chemical imaging sensitivity and specificity. A spectral analysis of the analyte may be conducted and compared with the spectra of biothreat agents.

    Abstract translation: 描述了使用超声波喷嘴来分析物高效沉积的装置和方法。 某些实施方案包括在相同空间位置上的多个喷雾应用，从而增加分析物浓度，以便定位和改善整个分子化学成像的敏感性和特异性。 可以进行分析物的光谱分析，并与生物降解剂的光谱进行比较。

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