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Patent Agency Ranking
公开(公告)号：US20250090025A1
公开(公告)日：2025-03-20
申请号：US18728810
申请日：2023-01-20
Applicant: DALHOUSIE UNIVERSITY , PROVINCIAL HEALTH SERVICES AUTHORITY
Inventor： Ian Patrick Joseph ALWAYN , Kevin Cecil HEWITT , Haishan ZENG , Hao GUO , Alexey TIKHOMIROV
IPC: A61B5/00 , G01N21/65 , G01N33/483
Abstract: An optical system and methods have been developed for real-time synchronous detection of vibration and/or rotation modes in biotic (e.g., fat, glyceride, vitamins, bilirubin, etc.) and abiotic systems (e.g., alcohol contents). The system and methods include a modulated light source (e.g., a CW laser of 1064 nm wavelength modulated at square wave signal at 5600 Hz by a square wave signal), laser beam shaping and light collecting optics, optical detectors, appropriately selected optical filters, mechanical or electronic laser beam modulator, electrical signal amplifiers (e.g., transimpedance, current and voltage amplifiers), synchronous detector (e.g. lock-in amplifier), data acquisition and hardware and software control systems. One or multiple lock-in amplifiers are used to extract weak signals from noisy background. The system has three configurations/embodiments for in-situ and ex-situ end uses—(i) tabletop probe, (ii) handheld probe and (iii) miniature handheld probe. The handheld probe is for ex-situ and open surgery whereas the tabletop probe can be combined with other systems for ex-situ (monitoring) assessments. The miniature handheld probe can be used in conjunction with needle biopsies. The weak signal of characteristic optical scattering (e.g., Raman scattering) peaks of target biotic indicators (e.g., glyceride, vitamins, bilirubin, etc.) and abiotic molecules (e.g., alcohol) are identified using sensitive lock-in amplification technique, which supersedes the state-of-the-art for other similar approaches and allows for the detection of weak Raman signals in ambient light conditions (e.g., LED and luminescent light). Without restricting the generality of the present disclosure, the system has been shown to provide a quantitative result of the fat content quickly and accurately in (i) lipid phantoms and (ii) liver samples, demonstrating a strong linear correlation (e.g., r>0.98) between output voltage signals and fat contents in the clinically relevant range.
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公开(公告)号：US20240225452A1
公开(公告)日：2024-07-11
申请号：US18415664
申请日：2024-01-18
Applicant: Provincial Health Services Authority
Inventor： Haishan ZENG , Michael SHORT , Yunxian TIAN
IPC: A61B5/00 , G01N21/3563 , G01N21/64 , G01N21/65
CPC classification number: A61B5/0075 , A61B5/0086 , G01N21/3563 , G01N21/6486 , G01N21/65 , A61B2562/0233 , G01N2201/08
Abstract: A system useful for in vivo and ex vivo spectroscopy comprises a water source connected to supply water through a passage to an outlet at a flow rate sufficient to issue a laminar water jet from the outlet, a light source operative to emit a light beam that is guided to a sample by the water jet, and an analysis unit connected to receive collected light that has been emitted from the sample into the water jet and operable to analyze the collected light. Some embodiments provide endoscopes with integrated light guides.
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公开(公告)号：US20220015638A1
公开(公告)日：2022-01-20
申请号：US17309374
申请日：2019-11-22
Applicant: PROVINCIAL HEALTH SERVICES AUTHORITY
Inventor： Haishan ZENG , Zhenguo WU , Harvey LUI , Yunxian TIAN
Abstract: Methods and apparatus for obtaining 3D imaging of tissue involve scanning a focused laser beam in xz planes to obtain a set of xz plane images spaced apart in a y direction. The xz plane images are processed to correct distortions and motions and combined to provide 3D image data. Surface flatting is optionally performed. Imaging may be performed using a femtosecond (fs) laser beam. Different components of light returning from the tissue may be detected and processed to yield plural co-registered images using different imaging modalities, for example, reflective confocal microscopy (RCM), two photon fluorescence (TPF) and second harmonic generation (SHG).
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公开(公告)号：US20210255041A1
公开(公告)日：2021-08-19
申请号：US17271826
申请日：2019-09-04
Applicant: PROVINCIAL HEALTH SERVICES AUTHORITY
Inventor： Zhenguo WU , Haishan ZENG , Jianhua ZHAO , Liwei JIANG
Abstract: Systems for confocal Raman spectroscopy of points of interest or regions of interest with concurrent imaging are disclosed. The imaging may be used for real time selection of points of interest or regions of interest for Raman spectroscopy and to monitor for unwanted motions of a sample while Raman spectra are acquired. Disclosed embodiments apply Reflectance confocal microscopy (RCM) in a confocal Raman spectroscopy system. A single laser may be used as a light source for both RCM and micro-Raman spectroscopy. A Faraday optical isolator may be applied to extract RCM signals for imaging. Systems as described herein have example application for ex vivo sample and in vivo skin measurement.
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公开(公告)号：US20210059513A1
公开(公告)日：2021-03-04
申请号：US16958062
申请日：2019-01-25
Applicant: PROVINCIAL HEALTH SERVICES AUTHORITY
Inventor： Hanna Claire MCGREGOR , Michael SHORT , Haishan ZENG
Abstract: A Raman endoscope for use in obtaining in vivo Raman spectra in the peripheral airways of the lungs and a method of constructing the Raman endoscope are disclosed. The endoscope has a tubular sheath containing a fiber bundle. The sheath has an outer diameter of less than 1.35 mm. The sheath is made of fluorinated ethylene propylene. The sheath is flexible along its length from a first end to a point along the sheath so that it can navigate sharp turns within the peripheral airways. A layer of coating covers the sheath along a terminal length and a probe tip of the fiber bundle. The terminal length extends along a length of the sheath extending from a second end opposite to the first end to the point. Terminal length is rigid to facilitate advancement of the endoscope towards the lesion of interest. Terminal length is 5 mm or less.
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