公开(公告)号：US10287342B2

公开(公告)日：2019-05-14

申请号：US15500921

申请日：2015-08-03

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Hak-Sung Kim ,  Da Eun Hwang ,  Jung-Min Choi ,  Joong-Jae Lee ,  Woosung Heu

IPC: A61K39/00 ,  A61K39/02 ,  C07H21/04 ,  C07K16/18 ,  C12N15/62 ,  C07K14/725 ,  C07K14/34 ,  A61K38/00

Abstract: The present invention relates to novel polypeptide for binding to a complement protein C5a. More particularly, the present invention relates to polypeptide which can be bound to a complement protein C5a and inhibit the activation of same, polynucleotide which codes for the polypeptide, a recombinant vector which comprises the polynucleotide, a recombinant microorganism to which the recombinant vector has been introduced, a method for producing the polypeptide by means of the recombinant microorganism, and a pharmaceutical composition, for treating immune diseases or sepsis, containing the polypeptide. A polypeptide, according to the present invention, can be bound to a complement protein C5a, with higher affinity compared to being bound to a complement protein C5a receptor which is present in nature, and inhibits the activation of same, thus being widely utilized for development of formulation for preventing or treating diseases related to a complement protein C5a.

公开(公告)号：US10508138B2

公开(公告)日：2019-12-17

申请号：US15737937

申请日：2015-09-16

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Hak-Sung Kim ,  Da Eun Hwang ,  Jeong Hyun Ryou

IPC: C07K14/00 ,  C07K14/475 ,  A61K38/16 ,  C07K14/46 ,  A61P27/02 ,  A61P35/00 ,  A61K38/00

Abstract: The present disclosure relates to a novel polypeptide capable of binding specifically to vascular endothelial growth factor, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a recombinant microorganism including the expression vector, a method of producing the polypeptide using the recombinant microorganism, a composition for treating or preventing age-related macular degeneration or cancer, which comprises the polypeptide, and a method for preventing or treating age-related macular degeneration or cancer, which comprises administering the composition for treating or preventing age-related macular degeneration or cancer, which comprises the polypeptide. The disclosed polypeptide is capable of binding to vascular endothelial growth factor to inhibit the activity thereof, and thus can be widely used as an agent for treating and preventing various diseases associated with vascular endothelial growth factor (VEGF).

公开(公告)号：US20180170980A1

公开(公告)日：2018-06-21

申请号：US15737937

申请日：2015-09-16

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Hak-Sung Kim ,  Da Eun Hwang ,  Jeong Hyun Ryou

IPC: C07K14/46 ,  A61P35/00 ,  A61P27/02

CPC classification number: C07K14/461 ,  A61K38/00 ,  A61P27/02 ,  A61P35/00 ,  C07K14/195 ,  C07K14/52 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/70

Abstract: The present disclosure relates to a novel polypeptide capable of binding specifically to vascular endothelial growth factor, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a recombinant microorganism including the expression vector, a method of producing the polypeptide using the recombinant microorganism, a composition for treating or preventing cancer, which comprises the polypeptide, and a method for preventing or treating cancer, which comprises administering the composition for treating or preventing cancer, which comprises the polypeptide. The disclosed polypeptide is capable of binding to vascular endothelial growth factor to inhibit the activity thereof, and thus can be widely used as an agent for treating and preventing various diseases associated with vascular endothelial growth factor (VEGF).