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公开(公告)号：US08557983B2
公开(公告)日：2013-10-15
申请号：US12793413
申请日：2010-06-03
Applicant: George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
Inventor： George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
IPC: C07D403/14 , C07D413/14
CPC classification number: C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US08362056B2
公开(公告)日：2013-01-29
申请号：US12739560
申请日：2008-11-04
Applicant: George A. Doherty
Inventor： George A. Doherty
IPC: A01N43/52 , A01N43/56 , A01N43/38 , A61K31/415 , A61K31/405 , C07D235/00 , C07D231/56 , C07D209/04
CPC classification number: C07D209/08 , C07D231/56 , C07D235/06 , C07D235/08
Abstract: Compounds of Formula I: I in which D1, D2, R1, R2, R7, R8 and A have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.
Abstract translation: 其中D1，D2，R1，R2，R7，R8和A具有本说明书中给出的含义的式I化合物是可用于治疗免疫疾病的DP2受体调节剂。
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公开(公告)号：US08163738B2
公开(公告)日：2012-04-24
申请号：US12064196
申请日：2006-08-17
Applicant: George A. Doherty , Zachary Jones
Inventor： George A. Doherty , Zachary Jones
IPC: A61P37/02 , A61K31/5513 , C07D243/20
CPC classification number: C07D243/20
Abstract: Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.
Abstract translation: 提供了可用于通过Toll样受体TLR8调节信号传导的组合物和方法。 组合物和方法用于治疗自身免疫，炎症过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。
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公开(公告)号：US08044069B2
公开(公告)日：2011-10-25
申请号：US12571862
申请日：2009-10-01
Applicant: Pramila A. Bhatia , George A. Doherty , Irene Drizin , Helmut Mack , Richard J. Perner , Andrew O. Stewart , Qingwei Zhang
Inventor： Pramila A. Bhatia , George A. Doherty , Irene Drizin , Helmut Mack , Richard J. Perner , Andrew O. Stewart , Qingwei Zhang
IPC: A61K31/4015 , A61K31/4025 , A61K31/45 , A61K31/4523 , C07D207/12 , C07D211/40
CPC classification number: C07D487/10 , C07D207/27 , C07D207/48 , C07D209/52 , C07D211/76 , C07D211/96 , C07D241/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, Ar2, L1, L2, n, R1, R4, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本申请涉及含有式（I）化合物的钙通道抑制剂，其中Ar1，Ar2，L1，L2，n，R1，R4，X和Y如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20090111969A1
公开(公告)日：2009-04-30
申请号：US12341683
申请日：2008-12-22
Applicant: Lawrence M. Blatt , Steven W. Andrews , Kevin R. Condroski , George A. Doherty , Yutong Jiang , John A. Josey , April L. Kennedy , Machender R. Madduru , Peter J. Stengel , Steven M. Wenglowsky , Benjamin T. Woodard , Laura Woodard
Inventor： Lawrence M. Blatt , Steven W. Andrews , Kevin R. Condroski , George A. Doherty , Yutong Jiang , John A. Josey , April L. Kennedy , Machender R. Madduru , Peter J. Stengel , Steven M. Wenglowsky , Benjamin T. Woodard , Laura Woodard
IPC: C07K5/00
CPC classification number: C07K5/0804
Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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Patent Agency Ranking
公开(公告)号：US20090105471A1
公开(公告)日：2009-04-23
申请号：US12341971
申请日：2008-12-22
Applicant: Lawrence M. Blatt , Steven W. Andrews , Kevin R. Condroski , George A. Doherty , Yutong Jiang , John A. Josey , April L. Kennedy , Machender R. Madduru , Peter J. Stengel , Steven M. Wenglowsky , Benjamin T. Woodard , Laura Woodard
Inventor： Lawrence M. Blatt , Steven W. Andrews , Kevin R. Condroski , George A. Doherty , Yutong Jiang , John A. Josey , April L. Kennedy , Machender R. Madduru , Peter J. Stengel , Steven M. Wenglowsky , Benjamin T. Woodard , Laura Woodard
IPC: C07D225/04 , C07D245/04
CPC classification number: C07K5/0804
Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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公开(公告)号：US20080306050A1
公开(公告)日：2008-12-11
申请号：US12064196
申请日：2006-08-17
Applicant: George A. Doherty , Zachary Jones
Inventor： George A. Doherty , Zachary Jones
IPC: A61K31/5513 , C07D243/14 , A61P37/02
CPC classification number: C07D243/20
Abstract: Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.
Abstract translation: 提供了可用于通过Toll样受体TLR8调节信号传导的组合物和方法。 组合物和方法用于治疗自身免疫，炎症过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。
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公开(公告)号：US20160137608A1
公开(公告)日：2016-05-19
申请号：US14881906
申请日：2015-10-13
Applicant: James Jeffry Howbert , Gregory N. Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachery Jones
Inventor： James Jeffry Howbert , Gregory N. Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachery Jones
IPC: C07D223/16 , C07D401/04 , C07D403/10 , C07D403/04 , C07D403/06 , C07D401/12
CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：US20140088085A1
公开(公告)日：2014-03-27
申请号：US13979634
申请日：2012-01-12
Applicant: Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
Inventor： Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
IPC: C07D223/16 , C07D243/14 , C07D487/04 , C07D401/12
CPC classification number: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，感染性疾病，炎症性疾病，移植排斥反应或移植物抗宿主病。
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10.发明授权公开(公告)号：US08586754B2
公开(公告)日：2013-11-19
申请号：US12793418
申请日：2010-06-03
Applicant: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC: C07D209/32 , C07D401/10
CPC classification number: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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