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公开(公告)号：US20110092485A1
公开(公告)日：2011-04-21
申请号：US12859178
申请日：2010-08-18
Applicant: James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong Woon Yang
Inventor： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong Woon Yang
IPC: A61K31/55 , C07D223/16 , A61P11/06 , A61P37/02 , A61P35/00
CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
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公开(公告)号：US08691809B2
公开(公告)日：2014-04-08
申请号：US12859178
申请日：2010-08-18
Applicant: James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong Woon Yang
Inventor： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong Woon Yang
IPC: A61K31/55 , C07D223/16 , A61P11/06 , A61P37/02 , A61P35/00
CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：US09718796B2
公开(公告)日：2017-08-01
申请号：US13979632
申请日：2012-01-12
Applicant: James Jeffry Howbert , Robert Hershberg , Laurence E. Burgess , Hong Woon Yang
Inventor： James Jeffry Howbert , Robert Hershberg , Laurence E. Burgess , Hong Woon Yang
IPC: A61K31/55 , C07D223/16 , C07D401/04 , C07D401/14 , C07D403/06 , C07D403/10 , C07D413/10 , C07D295/192 , C07D487/04
CPC classification number: C07D295/192 , A61K31/55 , C07D223/16 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
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公开(公告)号：US08524702B2
公开(公告)日：2013-09-03
申请号：US12859182
申请日：2010-08-18
Applicant: James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones
Inventor： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones
IPC: A61P35/00 , A61K31/55 , C07D223/16
CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
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公开(公告)号：US20140066432A1
公开(公告)日：2014-03-06
申请号：US13979632
申请日：2012-01-12
Applicant: James Jeffry Howbert , Robert Hershberg , Laurence E. Burgess , Hong Woon Yang
Inventor： James Jeffry Howbert , Robert Hershberg , Laurence E. Burgess , Hong Woon Yang
IPC: C07D413/10 , C07D223/16 , C07D403/10 , C07D295/192
CPC classification number: C07D295/192 , A61K31/55 , C07D223/16 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
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Patent Agency Ranking
公开(公告)号：US07829737B2
公开(公告)日：2010-11-09
申请号：US12043872
申请日：2008-03-06
Applicant: Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , Maher Qabar , Lauri Marie Schultz , Feng Hong , William Patt , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffry Howbert
Inventor： Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , Maher Qabar , Lauri Marie Schultz , Feng Hong , William Patt , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffry Howbert
IPC: C07F9/02
CPC classification number: C07F9/6541 , C07F9/3808 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/65517
Abstract: The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.
Abstract translation: 本发明提供了可用于调节蛋白酪氨酸磷酸酶-1b（PTP1B）酶的生物学活性的式（I）和式（II）的化合物。 本发明的化合物可用于治疗其中PTP1B酶是因子的疾病和/或病症。 这些疾病和/或病症包括但不限于1型糖尿病，2型糖尿病，葡萄糖耐量不足，胰岛素抵抗，肥胖症，高脂血症，高甘油三酯血症，高胆固醇血症，低HDL水平，动脉粥样硬化，血管再狭窄，炎性肠病， 胰腺炎，脂肪细胞瘤，脂肪细胞癌，脂肪肉瘤，血脂异常，癌症和神经变性疾病。
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公开(公告)号：US20090131374A1
公开(公告)日：2009-05-21
申请号：US12363422
申请日：2009-01-30
Applicant: Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , William Patt , Maher Qabar , Lauri Marie Schultz , Feng Hong , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffry Howbert
Inventor： Mark Arnold Thomas Blaskovich , Ted Baughman , Thomas Little , William Patt , Maher Qabar , Lauri Marie Schultz , Feng Hong , Gangadhar Nagula , Jennifer Lynn Gage , James Jeffry Howbert
IPC: A61K31/662 , A61P3/10
CPC classification number: C07F9/6541 , C07F9/3808 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/65517
Abstract: The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.
Abstract translation: 本发明提供了可用于调节蛋白酪氨酸磷酸酶-1b（PTP1B）酶的生物学活性的式（I）和式（II）的化合物。 本发明的化合物可用于治疗其中PTP1B酶是因子的疾病和/或病症。 这些疾病和/或病症包括但不限于1型糖尿病，2型糖尿病，葡萄糖耐量不足，胰岛素抵抗，肥胖症，高脂血症，高甘油三酯血症，高胆固醇血症，低HDL水平，动脉粥样硬化，血管再狭窄，炎性肠病， 胰腺炎，脂肪细胞瘤，脂肪细胞癌，脂肪肉瘤，血脂异常，癌症和神经变性疾病。
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公开(公告)号：US20160137608A1
公开(公告)日：2016-05-19
申请号：US14881906
申请日：2015-10-13
Applicant: James Jeffry Howbert , Gregory N. Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachery Jones
Inventor： James Jeffry Howbert , Gregory N. Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachery Jones
IPC: C07D223/16 , C07D401/04 , C07D403/10 , C07D403/04 , C07D403/06 , C07D401/12
CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：US20140088085A1
公开(公告)日：2014-03-27
申请号：US13979634
申请日：2012-01-12
Applicant: Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
Inventor： Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
IPC: C07D223/16 , C07D243/14 , C07D487/04 , C07D401/12
CPC classification number: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，感染性疾病，炎症性疾病，移植排斥反应或移植物抗宿主病。
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公开(公告)号：US20110118235A1
公开(公告)日：2011-05-19
申请号：US12859182
申请日：2010-08-18
Applicant: James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones
Inventor： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones
IPC: A61K31/55 , C07D403/10 , A61P37/02
CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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