Invention Grant
- Patent Title: Substituted benzoazepines as toll-like receptor modulators
- Patent Title (中): 取代苯并吖庚因作为toll样受体调节剂
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Application No.: US12859178Application Date: 2010-08-18
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Publication No.: US08691809B2Publication Date: 2014-04-08
- Inventor: James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong Woon Yang
- Applicant: James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong Woon Yang
- Applicant Address: US WA Seattle US CO Boulder
- Assignee: VentiRx Pharmaceuticals, Inc.,Array BioPharma, Inc.
- Current Assignee: VentiRx Pharmaceuticals, Inc.,Array BioPharma, Inc.
- Current Assignee Address: US WA Seattle US CO Boulder
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Heidi A. Erlacher; Lian Ouyang
- Main IPC: A61K31/55
- IPC: A61K31/55 ; C07D223/16 ; A61P11/06 ; A61P37/02 ; A61P35/00
Abstract:
Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Public/Granted literature
- US20110092485A1 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS Public/Granted day:2011-04-21
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