公开(公告)号：US11192950B2

公开(公告)日：2021-12-07

申请号：US16395009

申请日：2019-04-25

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: C07H21/02 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C12N5/00 ,  C12N5/16 ,  C12N1/20 ,  C07K16/28 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30 ,  G01N33/574 ,  C07K16/00 ,  A61K39/00

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US09580514B2

公开(公告)日：2017-02-28

申请号：US14400684

申请日：2013-03-14

Applicant: Genentech, Inc.

Inventor： Sunil Bhakta ,  Meredith Hazen ,  Jo-Anne S Hongo ,  Jagath R Junutula ,  Isidro Hotzel ,  Yonglei Shang ,  Shang-Fan Yu

IPC: A61K39/395 ,  C07K16/30 ,  A61K47/48 ,  A61K51/10 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6817 ,  A61K47/6855 ,  A61K51/1051 ,  A61K2039/505 ,  A61K2039/6037 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/77 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415 ,  G01N33/57423 ,  G01N2333/47 ,  G01N2500/02

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.

Abstract translation: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。 在某些方面，分离的核酸分子包含具有至少约80％核酸序列同一性，或至少约81％，82％，83％，84％，85％，86％，87％，88 ％，89％，90％，91％，92％，93％，94％，95％，96％，97％，98％，99％或100％的核酸序列同一性。 如本文公开的具有本文公开的氨基酸序列的全长TAT多肽，缺乏本文公开的信号肽的TAT多肽氨基酸序列，跨膜TAT多肽的胞外结构域，具有或不具有信号肽。

公开(公告)号：US20240383984A1

公开(公告)日：2024-11-21

申请号：US18675452

申请日：2024-05-28

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/30 ,  G01N33/574

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US12030947B2

公开(公告)日：2024-07-09

申请号：US17514824

申请日：2021-10-29

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00 ,  C07K16/00

CPC classification number: C07K16/283 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/30 ,  G01N33/57492 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/62 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/70535

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US20240067707A1

公开(公告)日：2024-02-29

申请号：US18065472

申请日：2022-12-13

Applicant: Genentech, Inc. ,  AC Immune SA

Inventor： Oskar Adolfsson ,  Gai Ayalon ,  Isidro Hotzel ,  Danielle Marie Di Cara

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US20200017579A1

公开(公告)日：2020-01-16

申请号：US16420673

申请日：2019-05-23

Applicant: AC Immune SA ,  Genentech, Inc.

Inventor： Oskar Adolfsson ,  Isidro Hotzel ,  Danielle DiCara

IPC: C07K16/18 ,  A61K39/395 ,  G01N33/577 ,  A61K47/68 ,  A61K45/06

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US20190112361A1

公开(公告)日：2019-04-18

申请号：US16140182

申请日：2018-09-24

Applicant: GENENTECH, INC. ,  AC IMMUNE SA

Inventor： Oskar Adolfsson ,  Gai Ayalon ,  Isidro Hotzel ,  Danielle Marie Di Cara

IPC: C07K16/18 ,  A61K45/06 ,  A61K39/395 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US20180125995A1

公开(公告)日：2018-05-10

申请号：US15612193

申请日：2017-06-02

Applicant: Genentech, Inc.

Inventor： Eric Brown ,  Wouter Hazenbos ,  Isidro Hotzel ,  Kimberly Kajihara ,  Sophie M. Lehar ,  Sanjeev Mariathasan ,  Thomas Pillow ,  Leanna Staben ,  Vishal Verma ,  Binqing Wei ,  Yi Xia ,  Min Xu

IPC: A61K47/68 ,  C07K16/12 ,  A61K31/5383 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K47/6803 ,  A61K31/5383 ,  A61K45/06 ,  A61K47/6835 ,  A61K47/6889 ,  A61P31/04 ,  C07K16/1271 ,  C07K2317/21

Abstract: The invention provides rF1 antibody antibiotic conjugates and methods of using same.

公开(公告)号：US20180021450A1

公开(公告)日：2018-01-25

申请号：US15611985

申请日：2017-06-02

Applicant: Genentech, Inc.

Inventor： Eric Brown ,  Wouter Hazenbos ,  Isidro Hotzel ,  Kimberly Kajihara ,  Sophie M. Lehar ,  Sanjeev Mariathasan ,  Thomas Pillow ,  Leanna Staben ,  Vishal Verma ,  Binqing Wei ,  Min Xu

IPC: A61K47/68 ,  A61K31/4468 ,  A61K39/40 ,  A61K31/496

CPC classification number: A61K47/6809 ,  A61K31/4468 ,  A61K31/496 ,  A61K39/40 ,  A61K47/6803 ,  A61K47/6835 ,  A61K47/6889

Abstract: The invention provides anti-Staphylococcus aureus antibody rifamycin antibiotic conjugates and methods of using same.

公开(公告)号：US11427629B2

公开(公告)日：2022-08-30

申请号：US16893678

申请日：2020-06-05

Applicant: AC Immune SA ,  Genentech, Inc.

Inventor： Oskar Adolfsson ,  Isidro Hotzel ,  Danielle DiCara

IPC: C07K16/18 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  G01N33/577 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61K39/00

Abstract: The invention provides anti-Tau antibodies and methods of using the same.