公开(公告)号：US20210139552A1

公开(公告)日：2021-05-13

申请号：US16998597

申请日：2020-08-20

Applicant: Genentech, Inc.

Inventor： Matthew KALO ,  Timothy Then-Chioh LU ,  Siddharth SUKUMARAN ,  Yehong WANG ,  Peter William DAY

IPC: C07K14/54 ,  A61K45/06 ,  A61P1/04

Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for the treatment of diseases associated with IL-22 (e.g., inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC (e.g., moderate to severe UC)) and Crohn's disease (CD)) and graft versus host disease (GVHD) (e.g., acute or chronic GVHD)).

公开(公告)号：US20220348687A1

公开(公告)日：2022-11-03

申请号：US17761727

申请日：2020-09-18

Applicant: Genentech, Inc.

Inventor： Joseph Haw-Ling LIN ,  Ryan Patrick OWEN ,  Sharon Marie RYMUT ,  Siddharth SUKUMARAN

IPC: C07K16/40 ,  A61P11/06

Abstract: The present invention features, inter alia, methods of treating a patient having asthma by administering an anti-tryptase antibody (e.g., anti-tryptase beta antibody) to the patient, anti-tryptase antibodies (e.g., anti-tryptase beta antibodies) for use in treating asthma, and uses of anti-tryptase antibodies (e.g., anti-tryptase beta antibodies), e.g., in the manufacture of medicaments for treating asthma.

公开(公告)号：US20210023176A1

公开(公告)日：2021-01-28

申请号：US16938802

申请日：2020-07-24

Applicant: Genentech, Inc.

Inventor： Matthew KALO ,  Timothy Then-Chioh LU ,  Melicent Clare PECK ,  Siddharth SUKUMARAN ,  Yehong WANG ,  Chin Yat WONG ,  Peter William DAY

IPC: A61K38/20 ,  A61P37/06 ,  A61K35/28 ,  A61K45/06 ,  A61K38/13 ,  A61K31/436 ,  A61K31/519 ,  A61K9/00 ,  C07K14/54

Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for preventing or treating graft versus host disease (GVHD) (e.g., acute or chronic GVHD, including corticosteroid-refractory acute GVHD).

公开(公告)号：US20220144910A1

公开(公告)日：2022-05-12

申请号：US17583891

申请日：2022-01-25

Applicant: Genentech, Inc.

Inventor： Matthew KALO ,  Timothy Then-Chioh LU ,  Melicent Clare PECK ,  Siddharth SUKUMARAN ,  Yehong WANG ,  Chin Yat WONG ,  Peter William DAY

IPC: C07K14/54 ,  A61P37/06

Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for preventing or treating graft versus host disease (GVHD) (e.g., acute or chronic GVHD, including corticosteroid-refractory acute GVHD).

公开(公告)号：US20180256711A1

公开(公告)日：2018-09-13

申请号：US15842380

申请日：2017-12-14

Applicant: Genentech, Inc.

Inventor： Ina P. RHEE ,  Jeong KIM ,  Mahrukh HUSENI ,  Eric STEFANICH ,  Siddharth SUKUMARAN ,  Chi-Chung LI

IPC: A61K39/395 ,  C07K16/28 ,  A61K9/00 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K9/0019 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/75 ,  C07K2317/76

Abstract: The invention provides methods of treating or delaying progression of cancer in an individual comprising administering to the individual an anti-human OX40 agonist antibody and an anti-PDL1 antibody. In some embodiments, the anti-human OX40 agonist antibody is administered in a dose selected from about 0.8 mg, about 3.2 mg, about 12 mg, about 40 mg, about 80 mg, about 130 mg, about 160 mg, about 300 mg, about 320 mg, about 400 mg, about 600 mg, and about 1200 mg, and the anti-PDL1 antibody is administered at a dose of about 800 mg or about 1200 mg.