公开(公告)号：US20210139552A1

公开(公告)日：2021-05-13

申请号：US16998597

申请日：2020-08-20

Applicant: Genentech, Inc.

Inventor： Matthew KALO ,  Timothy Then-Chioh LU ,  Siddharth SUKUMARAN ,  Yehong WANG ,  Peter William DAY

IPC: C07K14/54 ,  A61K45/06 ,  A61P1/04

Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for the treatment of diseases associated with IL-22 (e.g., inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC (e.g., moderate to severe UC)) and Crohn's disease (CD)) and graft versus host disease (GVHD) (e.g., acute or chronic GVHD)).

公开(公告)号：US20220144910A1

公开(公告)日：2022-05-12

申请号：US17583891

申请日：2022-01-25

Applicant: Genentech, Inc.

Inventor： Matthew KALO ,  Timothy Then-Chioh LU ,  Melicent Clare PECK ,  Siddharth SUKUMARAN ,  Yehong WANG ,  Chin Yat WONG ,  Peter William DAY

IPC: C07K14/54 ,  A61P37/06

Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for preventing or treating graft versus host disease (GVHD) (e.g., acute or chronic GVHD, including corticosteroid-refractory acute GVHD).

公开(公告)号：US20210023176A1

公开(公告)日：2021-01-28

申请号：US16938802

申请日：2020-07-24

Applicant: Genentech, Inc.

Inventor： Matthew KALO ,  Timothy Then-Chioh LU ,  Melicent Clare PECK ,  Siddharth SUKUMARAN ,  Yehong WANG ,  Chin Yat WONG ,  Peter William DAY

IPC: A61K38/20 ,  A61P37/06 ,  A61K35/28 ,  A61K45/06 ,  A61K38/13 ,  A61K31/436 ,  A61K31/519 ,  A61K9/00 ,  C07K14/54

Abstract: The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for preventing or treating graft versus host disease (GVHD) (e.g., acute or chronic GVHD, including corticosteroid-refractory acute GVHD).