公开(公告)号：US09981916B2

公开(公告)日：2018-05-29

申请号：US14533358

申请日：2014-11-05

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Andrew Cridland ,  Benjamin Fauber ,  Alberto Gobbi ,  Christopher Hurley ,  David Hurst ,  Jonathan Killen ,  Robert Maxey ,  Stuart Ward

IPC: C07D237/28 ,  C07D403/06 ,  C07D413/06 ,  C07D401/04 ,  C07D417/04 ,  C07D405/12 ,  C07D491/048 ,  C07D403/14 ,  C07D491/107 ,  C07D401/12

CPC classification number: C07D237/28 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/12 ,  C07D413/06 ,  C07D417/04 ,  C07D491/048 ,  C07D491/107

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20150126491A1

公开(公告)日：2015-05-07

申请号：US14533358

申请日：2014-11-05

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Andrew Cridland ,  Benjamin Fauber ,  Alberto Gobbi ,  Christopher Hurley ,  David Hurst ,  Jonathan Killen ,  Robert Maxey ,  Stuart Ward

IPC: C07D237/28 ,  C07D413/06 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D491/048 ,  C07D403/14 ,  C07D491/107 ,  C07D403/06 ,  C07D417/04

CPC classification number: C07D237/28 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/12 ,  C07D413/06 ,  C07D417/04 ,  C07D491/048 ,  C07D491/107

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药用盐，其中X，Ar 1，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。