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公开(公告)号：US20210324098A1
公开(公告)日：2021-10-21
申请号：US17217706
申请日：2021-03-30
申请人： Genentech, Inc.
IPC分类号： C07K16/28 , C12N5/00 , C07K16/18 , C07K16/22 , C07K14/705
摘要： The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
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公开(公告)号：US20170283505A1
公开(公告)日：2017-10-05
申请号：US15623226
申请日：2017-06-14
申请人： Genentech, Inc.
IPC分类号： C07K16/28 , C07K16/18 , C07K14/705 , C12N5/00 , C07K16/22
CPC分类号： C07K16/2878 , C07K14/70575 , C07K16/18 , C07K16/22 , C07K2317/14 , C07K2319/30 , C12N5/0018 , C12N5/0043 , C12N2500/32 , C12N2500/33 , C12N2500/90
摘要： The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
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公开(公告)号：US20190169667A1
公开(公告)日：2019-06-06
申请号：US16185369
申请日：2018-11-09
申请人： GENENTECH, INC.
发明人： Martin GAWLITZEK , Sven MARKERT , Oliver POPP , Masaru Ken SHIRATORI , Thomas TROEBS , Jessica WUU
摘要： Provided herein are cell culture media and methods culturing host cells expressing polypeptides to reduce the level of trisulfide bonds in polypeptides produced by the host cells.
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公开(公告)号：US20190023800A1
公开(公告)日：2019-01-24
申请号：US16138704
申请日：2018-09-21
申请人： Genentech, Inc.
IPC分类号： C07K16/28 , C07K16/22 , C12N5/00 , C07K14/705 , C07K16/18
摘要： The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
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公开(公告)号：US20180148510A1
公开(公告)日：2018-05-31
申请号：US15881308
申请日：2018-01-26
申请人： Genentech, Inc.
IPC分类号： C07K16/28 , C12N5/00 , C07K16/22 , C07K16/18 , C07K14/705
CPC分类号： C07K16/2878 , C07K14/70575 , C07K16/18 , C07K16/22 , C07K2317/14 , C07K2319/30 , C12N5/0018 , C12N5/0043 , C12N2500/32 , C12N2500/33 , C12N2500/90
摘要： The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
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公开(公告)号：US20190263921A1
公开(公告)日：2019-08-29
申请号：US16412791
申请日：2019-05-15
申请人： Genentech, Inc.
IPC分类号： C07K16/28 , C07K16/22 , C07K14/705 , C12N5/00 , C07K16/18
摘要： The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
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公开(公告)号：US20160024217A1
公开(公告)日：2016-01-28
申请号：US14670079
申请日：2015-03-26
申请人： GENENTECH, INC.
IPC分类号： C07K16/28 , C07K16/22 , C07K14/705 , C12N5/00
CPC分类号： C07K16/2878 , C07K14/70575 , C07K16/18 , C07K16/22 , C07K2317/14 , C07K2319/30 , C12N5/0018 , C12N5/0043 , C12N2500/32 , C12N2500/33 , C12N2500/90
摘要： The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture.
摘要翻译： 本发明一般涉及补充天冬酰胺的不含谷氨酰胺的细胞培养基。 本发明还涉及在天冬酰胺补充的不含谷氨酰胺的哺乳动物细胞培养物中重组蛋白质如抗体的产生。
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公开(公告)号：US20130281355A1
公开(公告)日：2013-10-24
申请号：US13841864
申请日：2013-03-15
申请人： GENENTECH, INC.
发明人： Natarajan VIJAYASANKARAN , Steven J. MEIER , Melissa S. MUN , Sharat VARMA , Yi YANG , Boyan ZHANG , Silvana R. AREVALO , Martin GAWLITZEK , Veronica CARVALHAL
CPC分类号： C12N5/0018 , C07K16/00 , C12N5/005 , C12N2500/24 , C12N2500/32 , C12N2500/38 , C12N2501/39 , C12P21/00
摘要： Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.
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