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公开(公告)号：US20240104948A1
公开(公告)日：2024-03-28
申请号：US18516417
申请日：2023-11-21
申请人： Genentech, Inc.
CPC分类号： G06V20/698 , G06T7/0012 , G06T7/11 , G06V10/25 , G06V10/267 , G06V10/77 , G06V10/82 , G06V20/695 , G06T2207/10056 , G06T2207/20021 , G06T2207/20081 , G06T2207/30024 , G06T2207/30096 , G06V2201/03
摘要： Systems and methods relate to processing digital pathology images. More specifically, techniques include accessing a digital pathology image that depicts a section of a biological sample, wherein the digital pathology image comprises regions displaying reactivity to a plurality of stains. For each of a plurality of tiles of the digital pathology image, a local-density measurement is calculated for each of a plurality of biological object types. One or more spatial-distribution metrics may be generated for the biological object types based at least in part on the calculated local-density measurements. A tumor immunophenotype may then be generated for the digital pathology image based at least in part on the local-density measurements or the one or more spatial-distribution metrics.
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公开(公告)号：US11299544B2
公开(公告)日：2022-04-12
申请号：US14850462
申请日：2015-09-10
申请人： Genentech, Inc.
IPC分类号： G01N33/574 , A61K39/00 , C07K16/28 , C12Q1/6886 , G01N33/68 , G06Q30/02
摘要： Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.
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公开(公告)号：US20130078252A1
公开(公告)日：2013-03-28
申请号：US13622878
申请日：2012-09-19
申请人： Genentech, Inc.
IPC分类号： A61K39/00 , A61K31/437 , A61K39/395 , G01N33/74 , G01N33/573 , A61K31/4545 , A61K31/4439 , C12Q1/68 , G01N33/574
CPC分类号： A61K39/3955 , A61K31/437 , A61K31/4439 , A61K31/4545 , A61K45/06 , C07K16/2863 , C07K16/3053 , C07K2317/75 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5091 , G01N33/573 , G01N33/5748 , G01N33/57488 , G01N33/57496 , G01N33/6872 , G01N33/74 , G01N2800/52 , A61K2300/00 , A61K39/39558
摘要： The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to therapies for the treatment of pathological conditions, such as cancer.
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公开(公告)号：US20240248092A1
公开(公告)日：2024-07-25
申请号：US18590121
申请日：2024-02-28
申请人： Genentech, Inc.
IPC分类号： G01N33/574 , A61K39/00 , A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30 , C12Q1/6886 , G06Q30/0241 , G06Q30/0251
CPC分类号： G01N33/57492 , A61K39/39558 , A61K45/06 , C07K16/2827 , C07K16/30 , C12Q1/6886 , G01N33/574 , G06Q30/0241 , G06Q30/0251 , A61K2039/505 , C07K2317/73 , C07K2317/76 , C12Q2600/106 , C12Q2600/158 , G01N2333/70532
摘要： Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.
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公开(公告)号：US08993249B2
公开(公告)日：2015-03-31
申请号：US13737550
申请日：2013-01-09
申请人： Genentech, Inc.
IPC分类号： G01N33/53 , C07K16/00 , C07K16/18 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2863
摘要： The invention provides anti-NRP1 antibodies and methods of using the same.
摘要翻译： 本发明提供抗NRP1抗体及其使用方法。
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公开(公告)号：US20140038959A1
公开(公告)日：2014-02-06
申请号：US13890411
申请日：2013-05-09
申请人： Genentech, Inc.
发明人： Klaus P. Hoeflich , Hartmut Koeppen , Christy Ong
IPC分类号： A61K31/519 , A61K45/06
CPC分类号： A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating tumors wherein PAK1 is over-expressed or amplified by co-administering a PAK1 inhibitor and a second anti-hyper-proliferative agent
摘要翻译： 本发明涉及一种治疗肿瘤的方法，其中PAK1通过共同施用PAK1抑制剂和第二抗超增殖剂过表达或扩增
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7.发明申请COMBINATION TREATMENTS COMPRISING C-MET ANTAGONISTS AND B-RAF ANTAGONISTS 审中-公开包含C-MET拮抗剂和B-RAF拮抗剂的组合治疗公开(公告)号：US20150125452A1
公开(公告)日：2015-05-07
申请号：US14535071
申请日：2014-11-06
申请人： GENENTECH, INC.
IPC分类号： A61K39/395 , G01N33/574 , C12Q1/68 , A61K31/437 , A61K31/4545
CPC分类号： A61K39/3955 , A61K31/437 , A61K31/4439 , A61K31/4545 , A61K45/06 , C07K16/2863 , C07K16/3053 , C07K2317/75 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5091 , G01N33/573 , G01N33/5748 , G01N33/57488 , G01N33/57496 , G01N33/6872 , G01N33/74 , G01N2800/52 , A61K2300/00 , A61K39/39558
摘要： The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to therapies for the treatment of pathological conditions, such as cancer.
摘要翻译： 本发明一般涉及分子生物学和生长因子调节领域。 更具体地，本发明涉及用于治疗诸如癌症的病理状况的治疗。
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8.发明授权公开(公告)号：US10240207B2
公开(公告)日：2019-03-26
申请号：US15272283
申请日：2016-09-21
申请人： Genentech, Inc.
发明人： Wei Yu , David Shames , Hartmut Koeppen , See Phan , Sandra Rost
IPC分类号： C12Q1/6886 , C07K16/22 , C07K16/28 , A61K39/00
摘要： The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.
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