公开(公告)号：US20140038959A1

公开(公告)日：2014-02-06

申请号：US13890411

申请日：2013-05-09

Applicant: Genentech, Inc.

Inventor： Klaus P. Hoeflich ,  Hartmut Koeppen ,  Christy Ong

IPC: A61K31/519 ,  A61K45/06

CPC classification number: A61K31/519 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of treating tumors wherein PAK1 is over-expressed or amplified by co-administering a PAK1 inhibitor and a second anti-hyper-proliferative agent

Abstract translation: 本发明涉及一种治疗肿瘤的方法，其中PAK1通过共同施用PAK1抑制剂和第二抗超增殖剂过表达或扩增

公开(公告)号：US20130345217A1

公开(公告)日：2013-12-26

申请号：US14012673

申请日：2013-08-28

Applicant: Genentech, Inc.

Inventor： Marcia Belvin ,  Lori Friedman ,  Klaus P. Hoeflich ,  Jeffrey Wallin

IPC: A61K31/5377 ,  A61K31/4523

CPC classification number: A61K31/5377 ,  A61K31/4523 ,  A61K31/505

Abstract: Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.