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公开(公告)号：US09688745B2
公开(公告)日：2017-06-27
申请号：US14981643
申请日：2015-12-28
发明人： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
CPC分类号： G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
摘要： The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US09266943B2
公开(公告)日：2016-02-23
申请号：US14103715
申请日：2013-12-11
发明人： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
CPC分类号： G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
摘要： The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US20180016325A1
公开(公告)日：2018-01-18
申请号：US15718876
申请日：2017-09-28
申请人： Genentech, Inc.
发明人： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： C07K16/12 , A61K45/06 , A61K39/40 , A61K31/4025 , A61K31/5386
CPC分类号： C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US20160222096A1
公开(公告)日：2016-08-04
申请号：US14981643
申请日：2015-12-28
发明人： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L.W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
IPC分类号： C07K16/12
CPC分类号： G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
摘要： The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US20160074529A1
公开(公告)日：2016-03-17
申请号：US14945716
申请日：2015-11-19
申请人： GENENTECH, INC.
发明人： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K47/48 , A61K31/7048 , A61K31/4709 , A61K38/12 , A61K31/4375 , A61K31/4436 , A61K31/7056 , A61K31/439
CPC分类号： A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US20180085470A1
公开(公告)日：2018-03-29
申请号：US15834740
申请日：2017-12-07
申请人： Genentech, Inc.
发明人： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K31/7056 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , C07K16/12 , A61K38/12 , A61K31/7048 , A61K31/4709
CPC分类号： A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies, antibiotic-linker intermediates, and antibody-antibiotic conjugate compound, and methods of making and using the same.
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公开(公告)号：US09927428B2
公开(公告)日：2018-03-27
申请号：US15246301
申请日：2016-08-24
发明人： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
CPC分类号： G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
摘要： The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US09895450B2
公开(公告)日：2018-02-20
申请号：US14945716
申请日：2015-11-19
申请人： Genentech, Inc.
发明人： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K39/395 , A61K47/48 , C07K16/12 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12
CPC分类号： A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US09803002B2
公开(公告)日：2017-10-31
申请号：US14292289
申请日：2014-05-30
申请人： Genentech, Inc.
发明人： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号： A61K39/40 , C07K16/12 , A61K31/5386 , A61K45/06 , A61K31/4025 , A61K47/68
CPC分类号： C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要： The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US09399673B2
公开(公告)日：2016-07-26
申请号：US13786206
申请日：2013-03-05
发明人： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
IPC分类号： C07K16/12
CPC分类号： G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
摘要： The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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