-
公开(公告)号：US20230076417A1
公开(公告)日：2023-03-09
申请号：US17714735
申请日：2022-04-06
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Joost MELIS , Tom VINK , Hendrik TEN NAPEL , Esther BREIJ , David SATIJN , Paul PARREN
Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10−9 and 10−8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.
-
公开(公告)号：US20220177585A1
公开(公告)日：2022-06-09
申请号：US17349482
申请日：2021-06-16
Applicant: GENMAB A/S
Inventor： Catharina Emanuele GERARDA HAVENITH , Tom VINK , Patrick VAN BERKEL , Paul PARREN
IPC: C07K16/28 , G01N33/566
Abstract: The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.
-
公开(公告)号：US20180298106A1
公开(公告)日：2018-10-18
申请号：US15909540
申请日：2018-03-01
Applicant: GENMAB A/S
Inventor： Michel DE WEERS , Tim WALSETH , Jan VAN DE WINKEL , Tom VINK , Paul PARREN
IPC: C07K16/28 , G01N33/573 , A61K45/06 , A61K39/395
Abstract: Isolated monoclonal antibodies which bind to human CD38 and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies.
-
公开(公告)号：US20180044431A1
公开(公告)日：2018-02-15
申请号：US15626866
申请日：2017-06-19
Applicant: GENMAB A/S
Inventor： Sandra VERPLOEGEN , David P.E. SATIJN , Rene M.A. HOET , Paul PARREN , Jan VAN DE WINKEL , Vibeke Miller BREINHOLT , Eva EHRNROOTH , Ole BAADSGAARD , Tom VINK , Willam Karel BLEEKER , Mischa HOUTKAMP , Maroeska OUDSHOORN , Rob N. DE JONG
IPC: C07K16/36 , A61K39/395 , A61K39/00
CPC classification number: C07K16/36 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92
Abstract: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
-
公开(公告)号：US20170029521A1
公开(公告)日：2017-02-02
申请号：US15197496
申请日：2016-06-29
Applicant: GENMAB A/S
Inventor： Jan VAN DE WINKEL , Tom VINK , Janine SCHUURMAN , Paul PARREN , Rob AALBERSE , Marijn VAN DER NEUT KOLFSCHOTEN
Abstract: The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).
Abstract translation: 本发明涉及稳定的IgG4抗体，涉及产生此类抗体的方法以及此类抗体作为药物的用途。 在一个主要方面，本发明涉及一种稳定的IgG4抗体，其包含重链和轻链，其中所述重链包含具有在位置（409）处的Arg残基取代的人IgG4恒定区， 位置（405）或位置（370）处的Lys残基。
-
Patent Agency Ranking
公开(公告)号：US20210171657A1
公开(公告)日：2021-06-10
申请号：US16880241
申请日：2020-05-21
Applicant: GENMAB A/S
Inventor： Sandra VERPLOEGEN , David P.E. SATIJN , Rene M.A. HOET , Paul PARREN , Jan VAN DE WINKEL , Vibeke Miller BREINHOLT , Eva EHRNROOTH , Ole BAADSGAARD, D.M.Sc. , Tom VINK , Willem Karel BLEEKER , Mischa HOUTKAMP , Maroeska OUDSHOORN , Rob N. DE JONG
IPC: C07K16/36 , A61K39/395 , A61K39/00
Abstract: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
-
公开(公告)号：US20170362319A1
公开(公告)日：2017-12-21
申请号：US15414254
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Catharina Emanuele GERARDA HAVENITH , Tom VINK , Patrick VAN BERKEL , Paul PARREN
IPC: C07K16/28 , G01N33/566
CPC classification number: C07K16/2812 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/732 , C07K2317/76 , G01N33/566 , G01N2333/70535
Abstract: The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.
-
公开(公告)号：US20170233497A1
公开(公告)日：2017-08-17
申请号：US15414122
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Ewald T. J. VAN DEN BREMER , Joost J. NEIJSSEN , Patrick VAN BERKEL , Bart DE GOEIJ , Tom VINK , Jan VAN DE WINKEL , Janine SCHUURMAN , Paul PARREN
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/6854
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins
-
9.发明申请TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS 审中-公开生产从这些动物获得的单一人类抗体和抗体的转基因动物公开(公告)号：US20170037138A1
公开(公告)日：2017-02-09
申请号：US15072983
申请日：2016-03-17
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Tom VINK , Jan VAN DE WINKEL , Aran Frank LABRIJN , Paul PARREN , Willem Karel BLEEKER , Frank BEURSKENS , Patrick VAN BERKEL
IPC: C07K16/28
CPC classification number: C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
Abstract: The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
Abstract translation: 本发明涉及新型非人转基因动物，其在抗原刺激时能够产生结合选定抗原的单价抗体，修饰的重链转基因，用于产生非人转基因动物的方法，用于免疫非人转基因动物的方法 动物以及通过这种免疫方法可获得的单价抗体。
-
公开(公告)号：US20160053020A1
公开(公告)日：2016-02-25
申请号：US14839514
申请日：2015-08-28
Applicant: GENMAB A/S
Inventor： Sandra VERPLOEGEN , David P.E. SATIJN , Rene M.A. HOET , Paul PARREN , Jan VAN DE WINKEL , Vibeke Miller BREINHOLT , Eva EHRNROOTH , Ole BAADSGAARD , Tom VINK , Willem Karel BLEEKER , Mischa HOUTKAMP , Maroeska OUDSHOORN , Rob N. DE JONG
IPC: C07K16/36
CPC classification number: C07K16/36 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92
Abstract: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
Abstract translation: 公开了结合人TF和相关的基于抗体的组合物和分子的分离的人单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
-
-
-
-
-
-
-
-
-
Search Results
20
records
(took 0.026 seconds)
