Invention Application
US20170037138A1 TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS
审中-公开
生产从这些动物获得的单一人类抗体和抗体的转基因动物
- Patent Title: TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS
- Patent Title (中): 生产从这些动物获得的单一人类抗体和抗体的转基因动物
-
Application No.: US15072983Application Date: 2016-03-17
-
Publication No.: US20170037138A1Publication Date: 2017-02-09
- Inventor: Janine SCHUURMAN , Tom VINK , Jan VAN DE WINKEL , Aran Frank LABRIJN , Paul PARREN , Willem Karel BLEEKER , Frank BEURSKENS , Patrick VAN BERKEL
- Applicant: GENMAB A/S
- Priority: DKPA200700795 20070531
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
Public/Granted literature
- US10351629B2 Recombinant IgG4 monovalent antibodies Public/Granted day:2019-07-16
Information query
