公开(公告)号：US20230076417A1

公开(公告)日：2023-03-09

申请号：US17714735

申请日：2022-04-06

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Joost MELIS ,  Tom VINK ,  Hendrik TEN NAPEL ,  Esther BREIJ ,  David SATIJN ,  Paul PARREN

IPC: C07K16/32 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28

Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10−9 and 10−8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.

公开(公告)号：US20190352423A1

公开(公告)日：2019-11-21

申请号：US16072437

申请日：2017-02-03

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Joost MELIS ,  Tom VINK ,  Hendrik TEN NAPEL ,  Esther BREIJ ,  David SATIJN ,  Paul PARREN

IPC: C07K16/32 ,  C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10−9 and 10−8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.