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公开(公告)号：US10600529B2
公开(公告)日：2020-03-24
申请号：US15532089
申请日：2015-12-04
Applicant: General Electric Company , Medi-Physics Inc.
Inventor： Matthew David Butts , Charles E. Shanks
Abstract: An equatorial anthropic radiation source and a method of making an equatorial anthropic radiation source are described. The radiation source is useful in diagnostic imaging applications in healthcare or other industries (e.g. computerized three-dimensional segmental imaging; Crompton scattering imaging techniques; radiation detector check and calibration, in particular CdZnTe detectors commonly used in medical imaging).
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公开(公告)号：US11670431B2
公开(公告)日：2023-06-06
申请号：US16791344
申请日：2020-02-14
Applicant: GENERAL ELECTRIC COMPANY , MEDI-PHYSICS INC.
Inventor： Matthew David Butts , Charles E. Shanks
CPC classification number: G21G4/08 , G21G1/001 , G21G1/02 , G21G4/06 , B29C39/003 , B29K2063/00 , B29K2505/08 , G21G1/06 , G21G2001/0094
Abstract: An equatorial anthropic radiation source and a method of making an equatorial anthropic radiation source are described. The radiation source is useful in diagnostic imaging applications in healthcare or other industries (e.g. computerized three-dimensional segmental imaging; Crompton scattering imaging techniques; radiation detector check and calibration, in particular CdZnTe detectors commonly used in medical imaging).
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公开(公告)号：US20170271038A1
公开(公告)日：2017-09-21
申请号：US15532089
申请日：2015-12-04
Applicant: General Electric Company , Medi-Physics Inc.
Inventor： Matthew David Butts , Charles E. Shanks
CPC classification number: G21G4/06 , B29C39/003 , B29K2063/00 , B29K2505/08 , G21G1/001 , G21G1/02 , G21G1/06 , G21G4/08 , G21G2001/0094
Abstract: An equatorial anthropic radiation source and a method of making an equatorial anthropic radiation source are described. The radiation source is useful in diagnostic imaging applications in healthcare or other industries (e.g. computerized three-dimensional segmental imaging; Crompton scattering imaging techniques; radiation detector check and calibration, in particular CdZnTe detectors commonly used in medical imaging).
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公开(公告)号：US11746288B2
公开(公告)日：2023-09-05
申请号：US17578335
申请日：2022-01-18
Applicant: General Electric Company
Inventor： Matthew David Butts , James Edward Murphy , Mark Daniel Doherty
CPC classification number: C09K11/617 , C09K11/02 , G02B6/005 , G02B6/0026 , H01L33/502 , H01L33/507
Abstract: Briefly, in one aspect, the present invention relates to processes for producing a stabilized Mn4+ doped phosphor in solid form and a composition containing such doped phosphor. Such process may include combining a) a solution comprising at least one substance selected from the group consisting of: K2HPO4, an aluminum phosphate, oxalic acid, phosphoric acid, a surfactant, a chelating agent, or a combination thereof, with b) a Mn4+ doped phosphor of formula I in solid form, where formula I may be: Ax [MFy]:Mn4+. The process can further include isolating the stabilized Mn4+ doped phosphor in solid form. In formula I, A may be Li, Na, K, Rb, Cs, or a combination thereof. In formula I, M may be Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Y, La, Nb, Ta, Bi, Gd, or a combination thereof. In formula I, x is the absolute value of the charge of the [MFy] ion and y is 5, 6 or 7.
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公开(公告)号：US10751429B2
公开(公告)日：2020-08-25
申请号：US16102368
申请日：2018-08-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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Patent Agency Ranking
公开(公告)号：US10052394B2
公开(公告)日：2018-08-21
申请号：US14550689
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
CPC classification number: A61K49/223 , A61K9/0009 , A61K9/5052
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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公开(公告)号：US09585974B2
公开(公告)日：2017-03-07
申请号：US15187115
申请日：2016-06-20
Applicant: General Electric Company
Inventor： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Andrew Soliz Torres
CPC classification number: A61K49/101 , A61K49/0002 , A61K49/04 , A61K49/0428 , A61K49/0485 , A61K49/1818 , A61K49/1848 , B82Y5/00 , B82Y30/00 , C01G35/00 , Y10S977/773 , Y10S977/779 , Y10S977/927 , Y10S977/928 , Y10T428/2982
Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.
Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。
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公开(公告)号：US11007285B2
公开(公告)日：2021-05-18
申请号：US16935998
申请日：2020-07-22
Applicant: General Electric Company
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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公开(公告)号：US20220135876A1
公开(公告)日：2022-05-05
申请号：US17578335
申请日：2022-01-18
Applicant: General Electric Company
Inventor： Matthew David Butts , James Edward Murphy , Mark Daniel Doherty
Abstract: Briefly, in one aspect, the present invention relates to processes for producing a stabilized Mn4+ doped phosphor in solid form and a composition containing such doped phosphor. Such process may include combining a) a solution comprising at least one substance selected from the group consisting of: K2HPO4, an aluminum phosphate, oxalic acid, phosphoric acid, a surfactant, a chelating agent, or a combination thereof, with b) a Mn4+ doped phosphor of formula I in solid form, where formula I may be: Ax [MFy]:Mn4+. The process can further include isolating the stabilized Mn4+ doped phosphor in solid form. In formula I, A may be Li, Na, K, Rb, Cs, or a combination thereof. In formula I, M may be Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Y, La, Nb, Ta, Bi, Gd, or a combination thereof. In formula I, x is the absolute value of the charge of the [MFy] ion and y is 5, 6 or 7.
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公开(公告)号：US11261375B2
公开(公告)日：2022-03-01
申请号：US16419206
申请日：2019-05-22
Applicant: General Electric Company
Inventor： Matthew David Butts , James Edward Murphy , Mark Daniel Doherty
Abstract: Briefly, in one aspect, the present invention relates to processes for producing a stabilized Mn4+ doped phosphor in solid form and a composition containing such doped phosphor. Such process may include combining a) a solution comprising at least one substance selected from the group consisting of: K2HPO4, an aluminum phosphate, oxalic acid, phosphoric acid, a surfactant, a chelating agent, or a combination thereof, with b) a Mn4+ doped phosphor of formula I in solid form, where formula I may be: Ax [MFy]:Mn4+. The process can further include isolating the stabilized Mn4+ doped phosphor in solid form. In formula I, A may be Li, Na, K, Rb, Cs, or a combination thereof. In formula I, M may be Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Y, La, Nb, Ta, Bi, Gd, or a combination thereof. In formula I, x is the absolute value of the charge of the [MFy] ion and y is 5, 6 or 7.
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