公开(公告)号：US08626270B2

公开(公告)日：2014-01-07

申请号：US13495408

申请日：2012-06-13

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

IPC分类号： A61B8/00 ,  A61B8/14 ,  A61B8/08 ,  A61B8/12

CPC分类号： A61B8/481 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61K49/222 ,  A61M37/0069

摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

摘要翻译： 本发明提供用于在有限时间内标记活检部位的材料，装置和方法。 活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。 粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。 用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。 系统可以包括含有粉末的管和含有无菌盐水的注射器。 管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

公开(公告)号：US08447386B2

公开(公告)日：2013-05-21

申请号：US12967639

申请日：2010-12-14

申请人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

发明人： Fred H. Burbank ,  Michael L. Jones ,  Frank Louw ,  Paul Lubock

IPC分类号： A61B6/00 ,  A61B10/00

CPC分类号： A61B90/39 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2090/3987 ,  A61K49/226

摘要： A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A releasable remotely detectable distal tip is coupled to the distal end of the delivery tube and is configured to be released to remain within the porous bioabsorbable body within the cavity upon the formation thereof.

摘要翻译： 一种用于至少部分地填充和标记患者体内的部位的空腔的系统包括标记物输送装置，其具有被配置为容纳标记物质并具有被构造成排出标记物质的机构的室。 标记物质的量被容纳在标记物输送装置的室内。 标记物质构造成至少部分地填充空腔并在其中形成多孔生物可吸收体。 输送管与标记物递送装置的腔室流体连通地联接。 输送管具有远端，其具有排出口，排出标记物质。 可释放的可远程检测的远侧末端联接到输送管的远端，并且构造成在其形成时被释放以保持在腔内的多孔生物可吸收体内。

公开(公告)号：US20090131825A1

公开(公告)日：2009-05-21

申请号：US12317100

申请日：2008-12-18

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Nancy Forcier

IPC分类号： A61B17/34

CPC分类号： A61B90/39 ,  A61B10/02 ,  A61B2017/00004 ,  A61B2090/3788 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3933 ,  A61B2090/395 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61M37/0069

摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by a delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

摘要翻译： 活检部位标记物，其具有至少一个生物可再吸收材料的小标记体或颗粒，例如具有不透射线对象的明胶，胶原，聚乳酸，聚乙醇酸，优选具有非生物构型。 具有不透射线物体的至少一个生物可吸收体或丸粒通过包括细长管状体的递送装置沉积到活检部位中，所述细长管状体具有可在管状体内滑动的活塞。 将管的一端放入活检部位。 至少一个但优选几个标记体或丸粒通过管子依次沉积到活检部位。 至少可检测标记的生物可吸收材料保持足够的量，以允许在引入之后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除，否则不干扰成像 导入后的第二时间点（如5-7个月）附近的组织组织。

公开(公告)号：US07322940B2

公开(公告)日：2008-01-29

申请号：US10790661

申请日：2004-03-01

申请人： Fred H. Burbank ,  Michael L. Jones ,  Paul Lubock

发明人： Fred H. Burbank ,  Michael L. Jones ,  Paul Lubock

IPC分类号： A61B10/00 ,  A61B18/18

CPC分类号： A61B10/0266 ,  A61B10/02 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/14 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2090/3908

摘要： An instrument assembly and method are described for isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required. In particular, the instrument assembly has a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along a distal portion of the shaft. The cutting element is actuatable between a retracted position within an electrically insulating recess and a radially extended position and is rotatable about its axis in the radially extended position to isolate a desire tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen.

摘要翻译： 描述了用于分离患者身体组织中的靶病变的器械组件和方法，导致当其被去除以用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。 这种方法有利地经常导致仅用单一经皮手术诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术。 特别地，仪器组件具有适于进入患者身体的远端，纵向轴和沿着轴的远端部分设置的切割元件。 切割元件可以在电绝缘凹槽中的缩回位置和径向延伸的位置之间致动，并且可以在其径向延伸的位置绕其轴线旋转，以通过围绕组织样本限定周边边缘来隔离期望的组织样本与周围组织。

公开(公告)号：US06958044B2

公开(公告)日：2005-10-25

申请号：US10004987

申请日：2001-12-04

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

IPC分类号： A61B10/02 ,  A61B10/00 ,  A61B17/00 ,  A61B17/22 ,  A61B17/32 ,  A61B17/34 ,  A61B18/12 ,  A61B18/14 ,  A61B19/00 ,  A61F2/82

CPC分类号： A61B10/04 ,  A61B10/02 ,  A61B10/0241 ,  A61B10/0266 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/12 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/320064 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2019/5487 ,  A61B2019/5491 ,  A61B2090/3908 ,  A61B2090/3991

摘要： Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

公开(公告)号：US06862470B2

公开(公告)日：2005-03-01

申请号：US10124757

申请日：2002-04-16

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones

IPC分类号： A61B6/00 ,  A61B6/12 ,  A61B8/08 ,  A61B8/12 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B19/00 ,  A61K49/00 ,  A61K49/04 ,  A61K49/22

CPC分类号： A61B8/481 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/006 ,  A61K49/222 ,  A61M37/0069

摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

摘要翻译： 本发明提供用于在有限时间内标记活检部位的材料，装置和方法。 活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。 粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。 用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。 系统可以包括含有粉末的管和含有无菌盐水的注射器。 管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

公开(公告)号：US06344026B1

公开(公告)日：2002-02-05

申请号：US09208535

申请日：1998-12-09

申请人： Fred H. Burbank ,  Richard L. Quick ,  Jacob Frank Louw ,  Michael L. Jones ,  Paul Lubock

发明人： Fred H. Burbank ,  Richard L. Quick ,  Jacob Frank Louw ,  Michael L. Jones ,  Paul Lubock

IPC分类号： A61B500

CPC分类号： A61B10/0266 ,  A61B10/02 ,  A61B17/00234 ,  A61B17/221 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/14 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/37 ,  A61B2017/00287 ,  A61B2017/2212 ,  A61B2017/320064 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2090/3908

摘要： A device for encapsulating tissue specimens includes a wand assembly, a sheath, and a guide assembly. The guide assembly pulls, draws, or otherwise moves the sheath about the tissue specimen. The wand assembly is disposed proximate to the tissue specimen, typically either adjacent or through the specimen. In an aspect of the encapsulating device, the guide assembly has sheath deployment members that are disposed about the tissue specimen. The sheath, which is attached to ends of the sheath deployment members and the wand assembly, is drawn over the tissue specimen as the sheath deployment members are pushed or pulled. In another aspect of the device, the guide assembly is an arm or a housing that rotates about the tissue specimen. The sheath, which is secured at one end to the guide assembly and at another end to the wand assembly, is drawn over the tissue specimen as the guide assembly rotates. The sheath may be made up of porous material, non-porous material, selectively permeable material, woven material, braided material, knit material, web material, mesh material, a film material, a flexible laminate material, or of an elastic material.

摘要翻译： 用于封装组织样本的装置包括棒组件，护套和引导组件。 引导组件拉动，牵引或以其他方式使护套围绕组织标本移动。 棒组件靠近组织标本设置，通常是相邻的或通过样本。 在封装装置的一个方面中，引导组件具有围绕组织标本设置的护套展开部件。 当护套展开构件被推动或拉动时，附接到鞘展开构件和杆组件的端部的护套被拉过组织标本。 在装置的另一方面，导向组件是围绕组织标本旋转的臂或壳体。 当引导组件旋转时，在一端固定到引导组件并且另一端固定到杆组件的护套在组织样本上被拉伸。 护套可以由多孔材料，无孔材料，选择性渗透材料，编织材料，编织材料，针织材料，纤维网材料，网状材料，薄膜材料，柔性层压材料或弹性材料制成。

公开(公告)号：US06261241B1

公开(公告)日：2001-07-17

申请号：US09159467

申请日：1998-09-23

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

IPC分类号： A61B1000

CPC分类号： A61B10/0266 ,  A61B10/02 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/14 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B2010/0208 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2090/3908

摘要： An electrosurgical biopsy device includes a stylet and a cannula movably mounted on a base. The stylet has a shaft with a head at its distal end and a stylet ablation element extending distally from the head. The stylet shaft is disposed through the cannula for axial translation therein between withdrawn and extended positions. The cannula has an opening at its distal end and a cannula ablation element adjacent the opening. Both ablation elements are activatable with energy that ablates adjacent tissue. A translation mechanism controllably moves (a) the stylet between the withdrawn and extended positions and (b) the cannula between a proximal position and a distal position relative to the base. In use, with the stylet in the withdrawn position against the distal end of the cannula, and with the stylet ablation element activated, the stylet and the cannula are pushed through the skin and the underlying tissue until the stylet head is adjacent a targeted tissue mass. Next, the stylet is extended distally from the distal end of the cannula so that its head penetrates the tissue mass. The cannula ablation element is then activated, and the cannula is pushed through the tissue mass toward the stylet head, thereby cutting a “core” through the tissue mass that is captured as a tissue specimen within the distal end of the cannula. The cannula and the stylet are then removed from the patient's body.

公开(公告)号：US08718745B2

公开(公告)日：2014-05-06

申请号：US12787177

申请日：2010-05-25

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick ,  Frank R. Louw ,  Stephen A. DeSantis

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick ,  Frank R. Louw ,  Stephen A. DeSantis

IPC分类号： A61B6/00

CPC分类号： A61B19/54 ,  A61B6/12 ,  A61B8/0833 ,  A61B90/39 ,  A61B2090/08021 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3987 ,  A61B2090/3991 ,  A61M37/0069

摘要： An intracorporeal site marker has high ultrasound reflectivity, presents a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The biopsy site marker may include features to fix the marker to the biopsy site so as to resist migration from the biopsy cavity.

摘要翻译： 体内位点标记物具有高超声反射率，从小标记物提供了显着的声学特征，以避免在随后的成像研究中模糊诊断组织特征，并且可以容易地与生物学特征区别开来。 活检部位标记可以包括将标记物固定到活检部位以防止从活检腔迁移的特征。

公开(公告)号：US20120277626A1

公开(公告)日：2012-11-01

申请号：US13543309

申请日：2012-07-06

申请人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

发明人： Fred H. Burbank ,  Paul Lubock ,  Michael L. Jones ,  Richard L. Quick

IPC分类号： A61B10/02

CPC分类号： A61B10/04 ,  A61B10/02 ,  A61B10/0241 ,  A61B10/0266 ,  A61B17/00491 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/3417 ,  A61B18/12 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1487 ,  A61B18/1492 ,  A61B90/17 ,  A61B90/37 ,  A61B90/39 ,  A61B2017/320064 ,  A61B2017/3488 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2018/162 ,  A61B2019/5487 ,  A61B2019/5491 ,  A61B2090/3908 ,  A61B2090/3991

摘要： A medical device for localization of tissue at a target site in a patient's body includes a tube having a distal end, a proximal end, and a longitudinal axis. The medical device is configured for placement of the distal end at the target site. A fixation device is disposed on the distal end. The affixation device is configured to mechanically fix the distal end of the medical device to tissue at the target site.

摘要翻译： 用于在患者体内的靶部位定位组织的医疗装置包括具有远端，近端和纵向轴线的管。 医疗装置被配置为将远端放置在目标位置处。 固定装置设置在远端。 固定装置构造成将医疗装置的远端机械地固定在目标部位的组织。