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公开(公告)号：US11813426B2
公开(公告)日：2023-11-14
申请号：US16753711
申请日：2018-10-01
Applicant: AMGEN INC.
Inventor： Ronald Forster , Gregory Gordon , Martin Hering , Matthew Wayne Janke , Andrew N. King , Wael Mismar
CPC classification number: A61M5/14248 , A61M5/1456 , A61M5/31571 , A61M2005/14256 , A61M2005/14506 , A61M2005/1585 , A61M2005/3154 , A61M2205/583
Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing, a container, a trigger member, and an interlock assembly. The trigger member may be selectively moveable relative to the housing to activate operation of at least one activatable element of the drug delivery device. The interlock assembly may include a lever mounted rotatably relative to the housing, a proximity sensor moveable between a first position extending beyond an exterior surface of the housing and a second position retracted toward the housing, and a rotational biasing member operably connected to the proximity sensor via the lever. When the proximity sensor is in the first position, the interlock assembly may limit movement of the trigger member relative to the housing. The rotational biasing member may be configured to exert a torque biasing the proximity sensor toward the first sensor position.
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公开(公告)号：US20220152308A1
公开(公告)日：2022-05-19
申请号：US17590175
申请日：2022-02-01
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US11298463B2
公开(公告)日：2022-04-12
申请号：US16839267
申请日：2020-04-03
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/31 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US11129941B2
公开(公告)日：2021-09-28
申请号：US15047815
申请日：2016-02-19
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Son C. Tran , Sheldon Moberg , Mark D. Holt
IPC: A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US11273260B2
公开(公告)日：2022-03-15
申请号：US17350883
申请日：2021-06-17
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/142
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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Patent Agency Ranking
公开(公告)号：US11191904B2
公开(公告)日：2021-12-07
申请号：US16154759
申请日：2018-10-09
Applicant: AMGEN INC.
Inventor： Julian Jazayeri , Ronald Forster , Jolita Seckute , Olivia Alice Henderson , Kristen Brown , Gregory Gordon , Rasmus Øhlenschlæger , Peter Dan Kaare Soelberg
Abstract: A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.
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公开(公告)号：US20210308381A1
公开(公告)日：2021-10-07
申请号：US17350883
申请日：2021-06-17
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/31 , B65B3/00 , B65B7/28 , B65B55/08 , B65B55/10 , A61M5/24 , A61M5/162 , A61M5/172 , A61M5/145 , A61M5/148 , A61M5/158
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US10314976B2
公开(公告)日：2019-06-11
申请号：US15040335
申请日：2016-02-10
Applicant: AMGEN INC.
Inventor： Francisca Tan-Malecki , Ronald Forster , Scott M. Nunn , Mark D. Holt , Son C. Tran , Sheldon Moberg
IPC: A61M5/24 , A61M5/31 , B65B3/00 , B65B7/28 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/158 , A61M5/162 , A61M5/172 , B65B55/08 , B65B55/10
Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
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公开(公告)号：US20240238529A1
公开(公告)日：2024-07-18
申请号：US18409480
申请日：2024-01-10
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Ronald Forster , Joseph Michael Iglesias , Matias Melander , Rasmus Øhlenschlæger , Christian Plambech , Lars Stenholt , Bjarke Lykke Ludvig Svendsen
CPC classification number: A61M5/3145 , A61M5/20 , A61M5/31583 , A61M2005/3143
Abstract: An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.
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公开(公告)号：US20230138654A1
公开(公告)日：2023-05-04
申请号：US16609466
申请日：2018-06-04
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Ronald Forster , Joseph Michael Iglesias , Matias Melander , Rasmus Øhelschlaeger , Christian Plambech , Lars Stenholt , Bjarke Lykke Ludvig Svendsen
Abstract: An injector includes a housing having a syringe assembly and an actuating mechanism at least partially disposed within the housing. The syringe assembly includes a syringe barrel that stores a medicament to be injected into a user, a needle assembly, and a filter member disposed adjacent to the needle assembly. The actuating mechanism is operatively coupled to the syringe assembly and includes a torque spring that exerts a torque to urge the medicament through the filter member to be injected into the user. The actuating mechanism further includes a damper mechanism that exerts an opposing force to dampen the motion exerted by the torque spring.
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