公开(公告)号：US20200230323A1

公开(公告)日：2020-07-23

申请号：US16839267

申请日：2020-04-03

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  A61M5/162 ,  A61M5/158 ,  A61M5/148 ,  A61M5/145 ,  A61M5/172 ,  A61M5/24 ,  B65B55/10 ,  B65B55/08 ,  B65B7/28 ,  B65B3/00

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US20190298927A1

公开(公告)日：2019-10-03

申请号：US16401471

申请日：2019-05-02

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  B65B55/10 ,  A61M5/162 ,  A61M5/24 ,  A61M5/172 ,  A61M5/145 ,  B65B55/08 ,  B65B7/28 ,  B65B3/00 ,  A61M5/158 ,  A61M5/148

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US20220152308A1

公开(公告)日：2022-05-19

申请号：US17590175

申请日：2022-02-01

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US11298463B2

公开(公告)日：2022-04-12

申请号：US16839267

申请日：2020-04-03

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/31 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/142

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US11129941B2

公开(公告)日：2021-09-28

申请号：US15047815

申请日：2016-02-19

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Son C. Tran ,  Sheldon Moberg ,  Mark D. Holt

IPC: A61M5/31 ,  B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/142

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product, including a granulocyte colony-stimulating factor (G-CSF). The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US20140288511A1

公开(公告)日：2014-09-25

申请号：US14350687

申请日：2012-10-11

Applicant: Francisca TAN-MALECKI ,  Ron FORSTER ,  Scott NUNN ,  Mark D. HOLT ,  Son TRAN ,  Sheldon MOBERG ,  AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ron Forster ,  Scott Nunn ,  Mark Dominis Holt ,  Son Tran ,  Sheldon Moberg

IPC: A61M5/162 ,  A61M5/172

CPC classification number: A61M5/31 ,  A61M5/14244 ,  A61M5/1452 ,  A61M5/148 ,  A61M5/158 ,  A61M5/162 ,  A61M5/1626 ,  A61M5/172 ,  A61M5/2455 ,  A61M5/2466 ,  A61M2005/247 ,  A61M2005/2474 ,  A61M2005/3114 ,  A61M2207/00 ,  B65B3/003 ,  B65B7/2821 ,  B65B55/08 ,  B65B55/10

Abstract: An injector (100) may include a container (102) having a wall (110) with an interior surface (112) and a seal assembly (140) with an interior surface (142), the interior surfaces (110) of the wall (110) and the seal assembly (140) defining a closed sterile reservoir (150) filled with a drug product. The injector (100) may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle (180) having a point (182) disposed only partially through the seal assembly (140) in a storage state, and disposed through the interior surface (142) of the seal assembly (140) into the sterile reservoir (150) in a delivery state. Further, the injection may include an actuator (106) that is adapted to move the container needle from the storage state to the delivery state.

Abstract translation: 注射器（100）可以包括容器（102），其具有带有内表面（112）的壁（110）和具有内表面（142）的密封组件（140），壁的内表面（110） 110）和所述密封组件（140）限定填充有药物的封闭的无菌容器（150）。 注射器（100）还可以包括流体递送系统，该流体输送系统包括清洁的，未套好的刚性容器针（180），其具有在存储状态下仅部分地设置穿过密封组件（140）的点（182），并且穿过内部 密封组件（140）的表面（142）在输送状态下进入无菌容器（150）。 此外，注射可以包括致动器（106），该致动器适于将容器针从储存状态移动到输送状态。

公开(公告)号：US11160931B2

公开(公告)日：2021-11-02

申请号：US16401471

申请日：2019-05-02

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/31 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/142

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US11058821B2

公开(公告)日：2021-07-13

申请号：US16687254

申请日：2019-11-18

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/142

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

公开(公告)号：US20200215273A1

公开(公告)日：2020-07-09

申请号：US16589037

申请日：2019-09-30

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Mark Ka Lai Lee ,  Donald Busby ,  Stephanie Toy ,  Suhas Krishna ,  Francisca Tan-Malecki ,  Ferry Tamtoro

IPC: A61M5/44 ,  A61M5/315 ,  A61M5/20 ,  A61M5/142 ,  A61M5/162 ,  A61M5/172 ,  A61M5/31

Abstract: A drug delivery system includes a reservoir and a drug delivery device coupled to the reservoir. The drug delivery device also may include at least one temperature-sensitive component and a lock having locked and unlocked states. The system further includes an output device, and a controller coupled to the lock and the output device. The controller may also include a temperature sensor, or may be coupled to the temperature sensor. The controller is programmed or configured to determine if the temperature of a drug in the reservoir or of the temperature-sensitive component exceeds an upper limit or is below a lower limit, and to activate the lock in either event. The controller is also programmed or configured to determine, directly or indirectly, if the temperature subsequently is between the upper and lower limits, and to unlock lock as a consequence.

公开(公告)号：US10537681B2

公开(公告)日：2020-01-21

申请号：US15040308

申请日：2016-02-10

Applicant: AMGEN INC.

Inventor： Francisca Tan-Malecki ,  Ronald Forster ,  Scott M. Nunn ,  Mark D. Holt ,  Son C. Tran ,  Sheldon Moberg

IPC: A61M5/31 ,  B65B3/00 ,  B65B7/28 ,  B65B55/08 ,  B65B55/10 ,  A61M5/24 ,  A61M5/162 ,  A61M5/172 ,  A61M5/145 ,  A61M5/148 ,  A61M5/158 ,  A61M5/142

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.